Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Article
Oncology
Bo Lv, Xianzhuo Liu, Xinfeng Zhu, Min Huang
Summary: This study found that miR-382-5p is upregulated in hepatocellular carcinoma and can activate the PI3K/Akt signaling pathway by targeting PTEN, promoting HCC cell invasion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
He Wang, Qiao Zhang, Wenyu Cui, Wenlan Li, Jimei Zhang
Summary: The circRNA hsa_circ_0004018 inhibits the proliferation and migration of HCC cells by sequestering miR-1197 and modulating the PTEN/PI3K/AKT signaling pathway.
Article
Biotechnology & Applied Microbiology
Qin Zhu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Ke-Jing Zhang, Yu-Qiong He, Yu Hu
Summary: The study suggests that circSLC8A1 plays a role in breast cancer by regulating the miR-671 and PTEN/PI3k/Akt signaling pathways, leading to inhibition of tumor growth and metastasis.
Article
Environmental Sciences
Xue Qi, Zeheng Ren, Yuan Cui, Jinxi Zhang, Yue Zhang, Shengchen Wang, Hongjin Lin
Summary: This study reveals that subacute CdCl2 exposure induces apoptosis and tissue damage in piglet adrenal gland. The exposure leads to a decrease in antioxidant enzymes, increase in heat shock protein, and upregulation of the miR9-5p-gene of PTEN, which activates the PI3K/AKT pathway. Activation of this pathway results in a significant increase in apoptosis-related factors and tissue damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Yiming Zhang, Zhaoyi Liu, Jing Lan, Jinliang Wang, Zhiqiang Shen, Guangliang Shi, Shu Li
Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Lei Wang, Yehui Zhou, Liang Jiang, Linlin Lu, Tiantian Dai, Aoshuang Li, Yan Chen, Lifeng Zhang
Summary: CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells.
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yulin Zhao, Aimin Li
Summary: Emerging studies have shown that miR-19b-3p is downregulated in IVDD patients and can suppress HNPC apoptosis and promote proliferation by regulating the PTEN/PI3K/Akt/mTOR pathway.
Article
Biochemistry & Molecular Biology
Gang Zhao, Xiaobao Shi, Zhanbo Sun, Pengfei Zhao, Zaiming Lu
Summary: PAQR4 is highly expressed in HCC and its knockdown inhibits cell proliferation and promotes apoptosis, while also blocking cell migration and invasion. Knockdown of PAQR4 sensitizes cells to chemotherapy and inhibits tumor growth through blocking the PI3K/AKT pathway activation.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Oncology
Yan Zhou, Jiannan Qiu, Siyuan Liu, Peng Wang, Ding Ma, Guang Zhang, Yin Cao, Lili Hu, Zhongxia Wang, Junhua Wu, Chunping Jiang
Summary: This study found that CFDP1 is highly expressed in hepatocellular carcinoma (HCC) and is positively correlated with adverse clinicopathological features. Overexpression of CFDP1 is associated with lower recurrence-free survival and overall survival. Furthermore, CFDP1 enhances the malignancy of HCC through the NEDD4-mediated PTEN/PI3K/AKT pathway.
Article
Biochemistry & Molecular Biology
Sayedeh Azimeh Hosseini, Morvarid Seidi, Hajar Yaghoobi
Summary: The miR-19a/b sponge effectively increased the expression of PTEN and TP53INP1 mRNA and promoted apoptosis in A549 lung cancer cell lines.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Lei Lv, Qiyi Yi, Ying Yan, Fengmei Chao, Ming Li
Summary: SPNS2 expression in CRC is regulated by copy number variation and DNA methylation, with high expression associated with colon adenoma and CRC, but low expression correlated with advanced stage and poor prognosis. Ectopic expression of SPNS2 inhibits proliferation, migration, invasion, and metastasis of CRC cells by regulating PTEN and Akt activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Changjiang Lei, Shaoting Li, Ying Fan, Li Hua, Qingyun Pan, Yuan Li, Zhixiong Long, Rui Yang
Summary: This study found that DUXAP8 plays a critical role in radiation resistance in breast cancer. High expression of DUXAP8 is associated with poor prognosis. DUXAP8 enhances radioresistance of breast cancer cells by modulating the PI3K/AKT/mTOR pathway and interacting with EZH2.
CANCER BIOLOGY & THERAPY
(2022)
Article
Oncology
Shigeki Nanjo, Sachiko Arai, Wei Wang, Shinji Takeuchi, Tadaaki Yamada, Akito Hata, Nobuyuki Katakami, Yasunori Okada, Seiji Yano
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Oncology
Yonghao Liang, Qisheng Li, Keli Chen, Wen Ni, Zetao Zhan, Feng Ye, Yiyi Li, Yuan Fang, Fengjiao Zhang, Longhua Chen, Yi Ding
Article
Oncology
Keli Chen, Fengjiao Zhang, Jie Ding, Yonghao Liang, Zetao Zhan, Yizhi Zhan, Long-hua Chen, Yi Ding
Article
Oncology
Yuqin Zhang, Jing Huang, Qisheng Li, Keli Chen, Yonghao Liang, Zetao Zhan, Feng Ye, Wen Ni, Longhua Chen, Yi Ding
Article
Oncology
Rong Wang, Shunli Peng, Xiaojuan Zhang, Zhenming Wu, Hezhen Duan, Yawei Yuan, Wei Wang
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Lu Yu, Feng Ye, Yi-Yi Li, Yi-Zhi Zhan, Yang Liu, Hong-Mei Yan, Yuan Fang, Yu-Wen Xie, Feng-Jiao Zhang, Long-Hua Chen, Yi Ding, Ke-Li Chen
Article
Biochemistry & Molecular Biology
Shunli Peng, Rong Wang, Xiaojuan Zhang, Yueyun Ma, Longhui Zhong, Ke Li, Akihiro Nishiyama, Sachiko Arai, Seiji Yano, Wei Wang
Article
Oncology
Longhui Zhong, Rong Wang, Yanxia Wang, Shunli Peng, Yueyun Ma, Sijie Ding, Hong Yang, Shiyu Chen, Xiaoqing Luo, Wei Wang
Review
Medicine, Research & Experimental
SiJie Ding, Rong Wang, ShunLi Peng, Xiaoqing Luo, LongHui Zhong, Hong Yang, YueYun Ma, ShiYu Chen, Wei Wang
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Oncology
Xiaoqing Luo, Shunli Peng, Sijie Ding, Qin Zeng, Rong Wang, Yueyun Ma, ShiYu Chen, Yanxia Wang, Wei Wang
Summary: The study demonstrates that SDPR expression is downregulated in lung cancer, and low expression is associated with shorter overall survival in patients. It may also be related to immune system suppression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yueyun Ma, Wenjie Li, Shiyu Chen, Shuimiao Lin, Sijie Ding, Xiaomei Zhou, Tongxin Liu, Rong Wang, Wei Wang
Summary: In this study, a comprehensive analysis was performed on patients with advanced or metastatic esophageal cancer who underwent next-generation sequencing (NGS). Mutations in 227 genes were identified, with TP53, NQO1, DPYD, GSTM1, XRCC1 and ERCC1 being the most common. Patients who received NGS-guided therapy showed improved clinical outcomes. The study highlights the importance of NGS in precision therapy for esophageal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Dermatology
Wenjie Li, Wei Wang
Summary: This study conducted a Mendelian randomization analysis and found that telomere length, birthweight, and height may be associated with an increased risk of basal cell carcinoma (BCC). This finding can help identify high-risk populations susceptible to BCC.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Wenjie Li, Wei Wang
Summary: Through large-scale genome-wide association studies, the associations between lipid metabolism, amino acids, and PD-1/PD-L1 were revealed. The study identified a negative association between alanine and PD-1 expression, and fourteen specific lipid metabolism biomarkers significantly linked to PD-L1 expression, including cholesterol and triglycerides. Glutamine and phenylalanine were also found to have a causal association with the expression of PD-L1. The findings suggest that targeting lipid and amino acid metabolisms may improve the efficacy of immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Wenjie Li, Wei Wang
Summary: This study reveals the genetic interconnectedness between PD-1/PD-L1 and circulating proteins, providing insights into the underlying mechanisms and potential implications in cancer immunotherapy.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Wen Ni, Yuqin Zhang, Zetao Zhan, Feng Ye, Yonghao Liang, Jing Huang, Keli Chen, Longhua Chen, Yi Ding
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2017)