Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids, and Disease Modeling

High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer

(2018) Feng Shan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

(2018) Devendra Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

(2018) Mehdi Jorfi et al.   Scientific Reports

Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids

(2018) Ran-Ran Zhang et al.   Stem Cell Reports

Multicellular Tumor Spheroids as an in Vivo–Like Tumor Model for Three-Dimensional Imaging of Chemotherapeutic and Nano Material Cellular Penetration

(2018) Hui-li Ma et al.   Molecular Imaging

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features

(2017) Malte Sgodda et al.   STEM CELLS AND DEVELOPMENT

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform

(2017) Kenji Kozuka et al.   Stem Cell Reports

Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies

(2016) Evangeline Tzatzalos et al.   ADVANCED DRUG DELIVERY REVIEWS

Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis

(2016) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Looking into the future: Using induced pluripotent stem cells to build two and three dimensional ocular tissue for cell therapy and disease modeling

(2016) Min Jae Song et al.   BRAIN RESEARCH

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

High-throughput imaging: Focusing in on drug discovery in 3D

(2016) Linfeng Li et al.   METHODS

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

(2016) Nienke R. Wevers et al.   Scientific Reports

Differential effects of MAPK pathway inhibitors on migration and invasiveness of BRAFV600E mutant thyroid cancer cells in 2D and 3D culture

(2015) Camilla Ingeson-Carlsson et al.   EXPERIMENTAL CELL RESEARCH

High-throughput fluorescence imaging approaches for drug discovery usingin vitroandin vivothree-dimensional models

(2015) Natalia J Martinez et al.   Expert Opinion on Drug Discovery

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration

(2015) Ruchira Singh et al.   MOLECULAR THERAPY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Automated analysis of contractile force and Ca2+ transients in engineered heart tissue

(2014) Andrea Stoehr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Robust T-tubulation and maturation of cardiomyocytes using tissue-engineered epicardial mimetics

(2014) Weining Bian et al.   BIOMATERIALS

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

iPS Cells for Modelling and Treatment of Retinal Diseases

(2014) Fred Chen et al.   Journal of Clinical Medicine

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Increased afterload induces pathological cardiac hypertrophy: a new in vitro model

(2012) Marc N. Hirt et al.   BASIC RESEARCH IN CARDIOLOGY

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Advances in the formation, use and understanding of multi-cellular spheroids

(2012) Toni-Marie Achilli et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration

(2012) Ruchira Singh et al.   HUMAN MOLECULAR GENETICS

Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation

(2012) L. Wang et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue

(2011) Malte Tiburcy et al.   CIRCULATION RESEARCH

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

(2011) Nathaniel L. Tulloch et al.   CIRCULATION RESEARCH

Generating human intestinal tissue from pluripotent stem cells in vitro

(2011) Kyle W McCracken et al.   Nature Protocols

Parkinson disease: The enteric nervous system spills its guts

(2011) P. Derkinderen et al.   NEUROLOGY

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Hereditary retinal disease

(2008) Peter Goodwin   CURRENT OPINION IN OPHTHALMOLOGY

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE

Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids

(2008) Hari R. Kumar et al.   PEDIATRIC SURGERY INTERNATIONAL

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

(2008) Britta Weigelt et al.   SEMINARS IN CANCER BIOLOGY