Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1

Store-operated calcium entry: Mechanisms and modulation

(2015) Patrick G. Hogan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors

(2015) G. C. Brailoiu et al.   BIOCHEMICAL JOURNAL

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

(2015) Aren van Waarde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders

(2014) Shang-Yi A Tsai et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry

(2014) Dilshan Balasuriya et al.   FEBS LETTERS

A Direct Interaction between the Sigma-1 Receptor and the hERG Voltage-gated K+Channel Revealed by Atomic Force Microscopy and Homogeneous Time-resolved Fluorescence (HTRF®)

(2014) Dilshan Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands

(2014) Katarzyna A. Gromek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

(2014) Aparna Gudlur et al.   Nature Communications

Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine

(2013) Saïd Kourrich et al.   CELL

Regulation of CRAC channels by protein interactions and post-translational modification

(2013) Sonal Srikanth et al.   Channels

Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

(2013) Abasha Lewis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Brain Sigma-1 Receptor Stimulation Improves Mental Disorder and Cardiac Function in Mice With Myocardial Infarction

(2013) Koji Ito et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Structure of the σ1 Receptor and Its Ligand Binding Site

(2013) Stefanie Brune et al.   JOURNAL OF MEDICINAL CHEMISTRY

Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases

(2013) Yasuo Miki et al.   NEUROPATHOLOGY

SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

(2013) Yoko Ono et al.   NEUROSCIENCE LETTERS

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

The essential roles of protein–protein interaction in sigma-1 receptor functions

(2013) Mohan Pabba   Frontiers in Cellular Neuroscience

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway

(2013) A Hyrskyluoto et al.   Cell Death & Disease

The sigma-1 receptor: a regulator of cancer cell electrical plasticity?

(2013) David Crottès et al.   Frontiers in Physiology

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Mitochondrial Ca2+ and apoptosis

(2012) Carlotta Giorgi et al.   CELL CALCIUM

Sigma-1 Receptors: Potential Targets for the Treatment of Substance Abuse

(2012) Matthew J. Robson et al.   CURRENT PHARMACEUTICAL DESIGN

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 Regulate Ca2+Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca2+Channel Orai1

(2012) Tatiana Kilch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na+Channel with 4-Fold Symmetry

(2012) Dilshan Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1

(2012) X. J. Xu et al.   JOURNAL OF CELL SCIENCE

The σ1 Receptor Antagonist S1RA Is a Promising Candidate for the Treatment of Neurogenic Pain

(2012) Bernhard Wünsch   JOURNAL OF MEDICINAL CHEMISTRY

Unraveling STIM2 function

(2012) Esther López et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Orai1, STIM1, and their associating partners

(2012) Sonal Srikanth et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)

(2012) S. Srikanth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

(2012) D. Willoughby et al.   Science Signaling

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression

(2011) K. Ito et al.   CARDIOVASCULAR RESEARCH

Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells

(2011) David Crottès et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters

(2011) G. Krapivinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IP3 receptor–mitochondria connection in apoptosis and autophagy

(2010) Jean-Paul Decuypere et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

(2010) Sonal Srikanth et al.   NATURE CELL BIOLOGY

The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

(2010) T.A. Mavlyutov et al.   NEUROSCIENCE

The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

(2010) C. Y. Park et al.   SCIENCE

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

(2010) Y. Wang et al.   SCIENCE

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC channels function independently of STIM1 and Orai1

(2009) Wayne I. DeHaven et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

(2009) A. Berna-Erro et al.   Science Signaling

Low density of sigma1 receptors in early Alzheimer’s disease

(2008) Masahiro Mishina et al.   ANNALS OF NUCLEAR MEDICINE

Sigma-1 receptor knockout mice display a depressive-like phenotype

(2008) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

Role of Sigma-1 Receptor C-terminal Segment in Inositol 1,4,5-Trisphosphate Receptor Activation

(2008) Zhiping Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY