Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates caspases in human prostate cancer cells through sigma 1 receptor

(2016) Dibash Das et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of astrocytes in optic nerve head fibrosis in glaucoma

(2016) Magdalena Schneider et al.   EXPERIMENTAL EYE RESEARCH

Neuroinflammation in glaucoma: soluble tumor necrosis factor alpha and the connection with excitotoxic damage

(2016) Adriana Di Polo et al.   Neural Regeneration Research

Sigma-1 receptor expression in the dorsal root ganglion: Reexamination using a highly specific antibody

(2016) Timur A. Mavlyutov et al.   NEUROSCIENCE

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

(2016) Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation

(2015) Mireille Happy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

(2015) Aren van Waarde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice

(2015) Maninder Malik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc−, the Na+-independent glutamate–cystine exchanger

(2015) Jing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression

(2015) Yuan Zhang et al.   Journal of Neuroinflammation

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain

(2014) J Y Moon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sigma receptors as potential therapeutic targets for neuroprotection

(2014) Linda Nguyen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

(2014) Brett H. Mueller et al.   EXPERIMENTAL EYE RESEARCH

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Astrocyte Processes Label for Filamentous Actin and Reorient Early Within the Optic Nerve Head in a Rat Glaucoma Model

(2014) S. Tehrani et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Sigma-1 receptor: a potential new target for Parkinson′s disease?

(2014) Veronica Francardo   Neural Regeneration Research

Sigma 1 Receptor plays a prominent role in IL-24-induced cancer-specific apoptosis

(2013) Winchie Do et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression

(2012) Felix J. Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells

(2012) Brett H. Mueller et al.   EXPERIMENTAL EYE RESEARCH

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice

(2011) Shigeki Moriguchi et al.   JOURNAL OF NEUROCHEMISTRY

The σ1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: A possible mechanism of neuroprotective action

(2010) F. Tan et al.   NEUROPHARMACOLOGY

Functions of astrocytes and their potential as therapeutic targets

(2010) Harold K. Kimelberg et al.   Neurotherapeutics

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

ERK and cell death: ERK1/2 in neuronal death

(2009) Srinivasa Subramaniam et al.   FEBS Journal

SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression

(2009) Tuerhong Tuerxun et al.   NEUROSCIENCE LETTERS

Primary Open-Angle Glaucoma

(2009) Young H. Kwon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38- and ERK-MAP kinases and NF-κB

(2003) John Rosenberger et al.   JOURNAL OF NEUROCHEMISTRY