Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass

Pathophysiological Characteristics Underlying Different Glucose Response Curves: A Latent Class Trajectory Analysis From the Prospective EGIR-RISC Study

(2018) Adam Hulman et al.   DIABETES CARE

Untimely oxidative stress in β-cells leads to diabetes – Role of circadian clock in β-cell function

(2018) J. Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study

(2018) Gretha Boersma et al.   HORMONE AND METABOLIC RESEARCH

Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation

(2018) Xiaoyan Wang et al.   INFLAMMATION

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

Impact of a multifactorial treatment programme on clinical outcomes and cardiovascular risk estimates: a retrospective cohort study from a specialised diabetes centre in Denmark

(2018) Narges Safai et al.   BMJ Open

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro

(2018) Xuan Wang et al.   PLoS One

Metformin as an Anticancer Agent

(2018) Ales Vancura et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

Metformin Mediates Protection againstLegionellaPneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species

(2017) Chiaki Kajiwara et al.   JOURNAL OF IMMUNOLOGY

Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system

(2017) Alan A. Wilson et al.   NUCLEAR MEDICINE AND BIOLOGY

Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data

(2017) L. Nesti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

(2017) Karthigayan Shanmugasundaram et al.   Nature Communications

Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity

(2017) Ezzaldin Ahmed Alfar et al.   Scientific Reports

Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer

(2016) K. J. Mather et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Imaging of myocardial fatty acid oxidation

(2016) Kieren J. Mather et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use

(2016) Olof Eriksson et al.   DIABETOLOGIA

Diabetes mellitus statistics on prevalence and mortality: facts and fallacies

(2016) Paul Zimmet et al.   Nature Reviews Endocrinology

Beta cell adaptation in pregnancy: a tribute to Claes Hellerström

(2016) Jens Høiriis Nielsen   UPSALA JOURNAL OF MEDICAL SCIENCES

Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4

(2015) Guanjun Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

Latent autoimmune diabetes of the adult: current knowledge and uncertainty

(2015) E. Laugesen et al.   DIABETIC MEDICINE

Improved clinical outcome 3 months after endovascular treatment, including thrombectomy, in patients with acute ischemic stroke: a meta-analysis

(2015) Anna Falk-Delgado et al.   Journal of NeuroInterventional Surgery

Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes

(2015) Hirotaka Watada et al.   MOLECULAR ENDOCRINOLOGY

Identification of type 2 diabetes subgroups through topological analysis of patient similarity

(2015) Li Li et al.   Science Translational Medicine

Distinctions Between Diagnostic and Classification Criteria?

(2015) Rohit Aggarwal et al.   ARTHRITIS CARE & RESEARCH

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Positron Emission Tomography Ligand [11C]5-Hydroxy-Tryptophan Can Be Used as a Surrogate Marker for the Human Endocrine Pancreas

(2014) O. Eriksson et al.   DIABETES

Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo

(2014) Wenhua Chu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?

(2013) Helen Vlassara et al.   Current Diabetes Reports

Insulin resistance in type 1 diabetes: what is ‘double diabetes’ and what are the risks?

(2013) S. J. Cleland et al.   DIABETOLOGIA

Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1  Activation

(2013) K.-H. Jung et al.   JOURNAL OF NUCLEAR MEDICINE

The Effect of High-Dose Insulin Analog Initiation Therapy on Lipid Peroxidation Products and Oxidative Stress Markers in Type 2 Diabetic Patients

(2013) Hazal Tuzcu et al.   Oxidative Medicine and Cellular Longevity

Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion

(2013) Maria Fernanda Graciano et al.   Islets

HyPer-3: A Genetically Encoded H2O2 Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging

(2012) Dmitry S. Bilan et al.   ACS Chemical Biology

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial

(2012) Alireza Esteghamati et al.   CLINICAL NUTRITION

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study

(2012) Z. Zhou et al.   DIABETES

Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition

(2012) M. R. Rizzo et al.   DIABETES CARE

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Miglitol, an Anti-diabetic Drug, Inhibits Oxidative Stress^|^ndash;Induced Apoptosis and Mitochondrial ROS Over-Production in Endothelial Cells by Enhancement of AMP-Activated Protein Kinase

(2012) Chie Aoki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Oxidative Stress Imaging in Live Animals with Techniques Based on Electron Paramagnetic Resonance

(2012) Martyna Elas et al.   RADIATION RESEARCH

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

(2011) J. Hirvonen et al.   DIABETES

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

(2011) Ismail Syed et al.   DIABETES

Insulin therapy has a complex relationship with measure of oxidative stress in type 2 diabetes: a case for further study

(2011) Louis Monnier et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Pancreatic alpha cell mass in European subjects with type 2 diabetes

(2011) J. C. Henquin et al.   DIABETOLOGIA

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?

(2011) JennaLynn Styskal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Gamma-Ray Emission Concurrent with the Nova in the Symbiotic Binary V407 Cygni

(2010) et al.   SCIENCE

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

(2009) Yuichiro Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Regulation of oxidative stress by glycaemic control: evidence for an independent inhibitory effect of insulin therapy

(2009) L. Monnier et al.   DIABETOLOGIA

Association of NAD(P)H Oxidase with Glucose-Induced Insulin Secretion by Pancreatic β-Cells

(2009) D. Morgan et al.   ENDOCRINOLOGY

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases

(2009) Marcus Gutscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

F2-Isoprostanes as Novel Biomarkers for Type 2 Diabetes: a Review

(2009) Subramanian Kaviarasan et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy

(2009) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

(2008) Cécile Guichard et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

(2008) C. Cervin et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic β-cell line, MIN6

(2008) Fumi Sawada et al.   METABOLISM-CLINICAL AND EXPERIMENTAL