Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation

Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes

(2016) Michelle L. Kerns et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Association between antidiabetic drugs and psoriasis risk in diabetic patients: Results from a nationwide nested case-control study in Taiwan

(2015) Chun-Ying Wu et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Metformin inhibits proliferation and proinflammatory cytokines of human keratinocytesin vitrovia mTOR-signaling pathway

(2015) Ying Liu et al.   PHARMACEUTICAL BIOLOGY

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

(2014) Allison B. Haugrud et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents

(2014) Minh Truong Do et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival

(2014) Juan M Funes et al.   Molecular Cancer

Reactive Oxygen Species Prevent Imiquimod-Induced Psoriatic Dermatitis through Enhancing Regulatory T Cell Function

(2014) Hyung-Ran Kim et al.   PLoS One

Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice

(2014) I. Khmaladze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low and high linear energy transfer radiation sensitization of HCC cells by metformin

(2013) E. H. KIM et al.   JOURNAL OF RADIATION RESEARCH

Risk of cancer in psoriasis: a systematic review and meta-analysis of epidemiological studies

(2013) C. Pouplard et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

(2013) Minh Truong Do et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels

(2013) Bo Kong et al.   Frontiers in Physiology

Keratin 16–Null Mice Develop Palmoplantar Keratoderma, a Hallmark Feature of Pachyonychia Congenita and Related Disorders

(2012) Juliane C. Lessard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Psoriasis uncovered

(2012) James Mitchell Crow   NATURE

Classical to Current Approach for Treatment of Psoriasis: A Review

(2012) Mahfoozur Rahman et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The Heme Oxygenase-1 Protein Is Overexpressed in Human Renal Cancer Cells following Activation of the Ras-Raf-ERK Pathway and Mediates Anti-Apoptotic Signal

(2011) Pallavi Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 target genes are induced under marginal selenium-deficiency

(2010) Mike Müller et al.   Genes and Nutrition

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study

(2008) Yolanda B. Brauchli et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY