Article
Biochemistry & Molecular Biology
Pierre Cheung, Olof Eriksson
Summary: Diabetes is a chronic metabolic disease that affects over 400 million people globally, with traditional diagnostic methods having limitations in accurately reflecting disease progression. Studying beta-cell mass is crucial for understanding disease processes, but invasive procedures are required. Nuclear medical imaging techniques offer a non-invasive approach for studying beta-cell mass, potentially leading to breakthroughs in diabetes research and therapies.
Article
Medicine, Research & Experimental
Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, J. V. Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline, Kiran Kumar Solingapuram Sai
Summary: Overproduction of reactive oxygen species (ROS) due to altered redox regulation is common in many cancers. While PET imaging is the standard tool for cancer imaging, there are no clinically-approved PET radiotracers for ROS imaging. An ascorbate-based radioligand, [18F] KS1, shows promise in tracking ROS and demonstrates good safety and translational potential in animal models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuting Li, Jianhua Feng, Teng Zhang, Kexin Shi, Yao Ding, Xiaohui Zhang, Chentao Jin, Jiayue Pan, Le Xue, Yi Liao, Xiawan Wang, Cheng Zhuo, Hong Zhang, Mei Tian
Summary: Atypical BECTS showed more widespread and severe hypo-metabolism than typical BECTS, and the combination of metabolic characteristics and clinical variables has the potential for clinical use in distinguishing between typical and atypical BECTS.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Maximilian Grosch, Leonie Beyer, Magdalena Lindner, Lena Kaiser, Seyed-Ahmad Ahmadi, Anna Stockbauer, Peter Bartenstein, Marianne Dieterich, Matthias Brendel, Andreas Zwergal, Sibylle Ziegler
Summary: Metabolic connectivity patterns based on [F-18]-FDG PET were used to classify rats after unilateral labyrinthectomy, achieving high accuracy compared to random and machine learning classification. This novel statistical method shows potential for supporting PET-based diagnostic decisions in neurological disorders.
Article
Cardiac & Cardiovascular Systems
Jing Wu, Nabil E. Boutagy, Zhengxin Cai, Shu-fei Lin, Ming-Qiang Zheng, Attila Feher, John C. Stendahl, Michael Kapinos, Jean-Dominique Gallezot, Hui Liu, Tim Mulnix, Wenjie Zhang, Marcel Lindemann, Jo-ku Teng, Edward J. Miller, Yiyun Huang, Richard E. Carson, Albert J. Sinusas, Chi Liu
Summary: The objective of this study was to develop a dynamic PET imaging technique for absolute quantification of myocardial reactive oxygen species production in a large animal model. The results showed that dynamic scanning and kinetic modeling can provide reliable data on myocardial superoxide production, and generate high-quality parametric images.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moath Said Alfawara, Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Fares Alahdab, Mahmoud Al Rifai, Mahwash Kassi, Talal Alnabelsi, William A. Zoghbi, Mouaz H. Al-Mallah
Summary: This study evaluated the use of serum beta-hydroxybutyrate (BHB) to identify adequate suppression of the left ventricle (LV) in patients undergoing cardiac inflammatory/infectious studies. The results showed that serum BHB level can be used to determine sufficient LV suppression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Ming Chen, Mingchih Chen, Jeng-Guan Hsu, Tian-Shyug Lee, Ben-Chang Shia, Szu-Yuan Wu
Summary: The use of preoperative PET/CT is associated with a lower risk of death in patients with resectable stage IIIA-IIIB non-small cell lung cancer, but it does not improve survival rates in patients with stage I-II cancer.
Review
Endocrinology & Metabolism
Takaaki Murakami, Hiroyuki Fujimoto, Nobuya Inagaki
Summary: Pancreatic beta-cell dysfunction and reduced mass are central in diabetes, but non-invasive evaluation of beta-cell mass remains elusive. Recent nuclear medical techniques using GLP-1R-targeted imaging probes show promise in evaluating beta-cell mass in diabetes management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Oscar Moreno, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Rossana Passannante, Ignacio Tobalina-Larrea, Pedro Ramos-Cabrer, Albert Giralt, Magdalena Sastre, Estibaliz Capetillo-Zarate, Urban Kosak, Damijan Knez, Stanislav Gobec, Mariel Marder, Abraham Martin, Jordi Llop
Summary: The study investigated the potential of butyrylcholinesterase (BChE) as an early biomarker for Alzheimer's disease (AD) by analyzing its abundance in the brains of AD model animals and controls. The results suggested that BChE accumulation in the brain is associated with amyloid beta deposition, indicating its promising role as an early biomarker for AD.
Review
Oncology
Malik E. Juweid, Marguerite Mueller, Abdullah Alhouri, M. Ziad A-Risheq, Felix M. Mottaghy
Summary: F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is essential for lymphoma staging and management, especially for FDG-avid lymphomas. PET/CT interim application can assist in prognostication and early treatment adjustment.
Article
Biochemistry & Molecular Biology
Maria Gronman, Olli Moisio, Xiang-Guo Li, Tarja Toimela, Outi Huttala, Tuula Heinonen, Juhani Knuuti, Anne Roivainen, Antti Saraste
Summary: In this study, the binding of [Ga-68]NODAGA-RGDyK to α(v)β(3) integrin in a human cell-based 3D in vitro model of angiogenesis was measured, showing a gradual increase in tracer binding with neovasculature density. The uptake of [Ga-68]NODAGA-RGDyK closely reflected the amount of angiogenesis, supporting further evaluation of RGD-based approaches for targeted imaging of angiogenesis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Medicine, General & Internal
Debora E. Peretti, Federica Ribaldi, Max Scheffler, Linjing Mu, Valerie Treyer, Anton F. F. Gietl, Christoph Hock, Giovanni B. B. Frisoni, Valentina Garibotto
Summary: The study aimed to describe the prevalence of different ATN profiles using quantitative imaging biomarkers in two independent cohorts, and to evaluate the pertinence of ATN biomarkers to identify comparable populations across the cohorts. The results showed that the imaging biomarkers for ATN profiles were significantly different between the cohorts, but no longer significant when stratifying the cohorts by ATN profile.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maximilian Merz, Almuth Maria Anni Merz, Jie Wang, Lei Wei, Qiang Hu, Nicholas Hutson, Cherie Rondeau, Kimberly Celotto, Ahmed Belal, Ronald Alberico, AnneMarie W. Block, Hemn Mohammadpour, Paul K. Wallace, Joseph Tario, Jesse Luce, Sean T. Glenn, Prashant Singh, Megan M. Herr, Theresa Hahn, Mehmet Samur, Nikhil Munshi, Song Liu, Philip L. McCarthy, Jens Hillengass
Summary: This study characterizes osteolytic lesions (OL) in multiple myeloma patients using single-cell RNA sequencing (scRNA-seq), revealing specifically regulated genes in OL compared to random bone marrow samples, as well as their response to induction therapy.
NATURE COMMUNICATIONS
(2022)