Metformin Mediates Protection againstLegionellaPneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species

AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway

(2016) Haleh Vaez et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

(2016) Takuma Higurashi et al.   LANCET ONCOLOGY

Metformin: An anti-diabetic drug to fight cancer

(2016) Marie Daugan et al.   PHARMACOLOGICAL RESEARCH

Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression

(2016) Zhong’e Zhou et al.   Journal of Diabetes Research

Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses

(2016) Tonya J. Webb et al.   Pathogens and Disease

Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation

(2015) Daniel A. Escobar et al.   JOURNAL OF SURGICAL RESEARCH

Energy restriction and potential energy restriction mimetics

(2015) Sibylle Nikolai et al.   NUTRITION RESEARCH REVIEWS

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AICAR Enhances the Phagocytic Ability of Macrophages towards Apoptotic Cells through P38 Mitogen Activated Protein Kinase Activation Independent of AMP-Activated Protein Kinase

(2015) Hui Quan et al.   PLoS One

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

(2014) Alba Luengo et al.   BMC BIOLOGY

Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction

(2014) Juyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2014) Dae Won Park et al.   MOLECULAR MEDICINE

Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

(2014) Pratima Nangia-Makker et al.   PLoS One

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling

(2014) Altaf Mohammed et al.   Translational Oncology

Diabetes, pancreatic cancer, and metformin therapy

(2014) Jun Gong et al.   Frontiers in Physiology

AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

(2013) Arie J. Hoogendijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Metformin intake is associated with better survival in ovarian cancer

(2012) Sanjeev Kumar et al.   CANCER

Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells

(2012) Chang W. Song et al.   Scientific Reports

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

(2012) Atsushi Sato et al.   Stem Cells Translational Medicine

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils

(2011) Hong-Beom Bae et al.   FASEB JOURNAL

Roles of Interleukin-17 in an Experimental Legionella pneumophila Pneumonia Model

(2011) Yoshifumi Kimizuka et al.   INFECTION AND IMMUNITY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

(2010) Konstantin Tsoyi et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Host cell processes that influence the intracellular survival of Legionella pneumophila

(2008) Sunny Shin et al.   CELLULAR MICROBIOLOGY

A Hemidominant Naip5 Allele in Mouse Strain MOLF/Ei-Derived Macrophages Restricts Legionella pneumophila Intracellular Growth

(2008) V. P. Losick et al.   INFECTION AND IMMUNITY

Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

(2008) Nan-Lan Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY