Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs

The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl-1: potential role of p38-MAPK in regulation of Mcl-1 turnover

(2018) P. Phoomvuthisarn et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

(2018) Jennifer M. Felton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use

(2018) Terence Ndonyi Bukong et al.   JOURNAL OF HEPATOLOGY

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation

(2018) John A. Marwick et al.   Cell Death & Disease

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis

(2018) Scott P. Davies et al.   Frontiers in Immunology

Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: subversion towards autoimmunity by proteinase 3

(2018) Nathalie Thieblemont et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase Axis

(2018) Nicole D. Barth et al.   JOURNAL OF IMMUNOLOGY

Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy

(2018) Peng Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

(2017) Robert D Gray et al.   THORAX

The “Phagocytic Synapse” and Clearance of Apoptotic Cells

(2017) Nicole D. Barth et al.   Frontiers in Immunology

Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria

(2016) Claes Dahlgren et al.   BIOCHEMICAL PHARMACOLOGY

Neutrophil-derived myeloperoxidase promotes atherogenesis and neointima formation in mice

(2016) Vedat Tiyerili et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

(2016) Laurent Meijer et al.   Journal of Innate Immunity

Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system

(2016) Laura Planells-Ferrer et al.   JOURNAL OF NEUROCHEMISTRY

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

(2016) Claudia Z. Han et al.   NATURE

Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis

(2016) Jameel Barnawi et al.   RESPIROLOGY

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Key mechanisms governing resolution of lung inflammation

(2016) C. T. Robb et al.   Seminars in Immunopathology

The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome

(2016) David A Dorward et al.   THORAX

Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo

(2016) Laura J. Hoodless et al.   Scientific Reports

Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation

(2015) Christopher D. Lucas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

(2015) M. E. M. Dolman et al.   CLINICAL CANCER RESEARCH

Cyclin-dependent kinase 5 regulates degranulation in human eosinophils

(2015) Solomon O. Odemuyiwa et al.   IMMUNOLOGY

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines

(2015) Y-S Yoon et al.   Mucosal Immunology

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

The resolution of inflammation: Principles and challenges

(2015) Sarah E. Headland et al.   SEMINARS IN IMMUNOLOGY

New insights into the resolution of inflammation

(2015) Derek Gilroy et al.   SEMINARS IN IMMUNOLOGY

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells

(2015) I Dransfield et al.   Cell Death & Disease

A Phase I study of cyclin-dependent kinase inhibitor, AT7519, in patients with advanced cancer: NCIC Clinical Trials Group IND 177

(2014) E X Chen et al.   BRITISH JOURNAL OF CANCER

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Successful Treatment of Animal Models of Rheumatoid Arthritis with Small-Molecule Cyclin-Dependent Kinase Inhibitors

(2014) C. Sekine et al.   JOURNAL OF IMMUNOLOGY

Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock

(2014) Y. Ren et al.   JOURNAL OF IMMUNOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclin-Dependent Kinase 9 Inhibition Protects Cartilage From the Catabolic Effects of Proinflammatory Cytokines

(2014) Jasper H. N. Yik et al.   Arthritis & Rheumatology

Eosinophils in the Lung – Modulating Apoptosis and Efferocytosis in Airway Inflammation

(2014) Jennifer M. Felton et al.   Frontiers in Immunology

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

(2013) Gabriele Montanaro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Control of Myeloid Cell Trafficking in Resolution

(2013) Lucy V. Norling et al.   Journal of Innate Immunity

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

(2013) John A. Marwick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

(2013) C D Lucas et al.   Mucosal Immunology

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Apoptosis therapy: driving cancers down the road to ruin

(2013) Douglas R. Green et al.   NATURE MEDICINE

Resolution of inflammation: Mechanisms and opportunity for drug development

(2013) Ana L. Alessandri et al.   PHARMACOLOGY & THERAPEUTICS

Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1

(2013) Sanjivan Gautam et al.   PLoS One

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury

(2013) Nikolaos G. Almyroudis et al.   Frontiers in Immunology

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

(2012) A E Leitch et al.   CELL DEATH AND DIFFERENTIATION

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

(2012) Christopher D. Lucas et al.   FASEB JOURNAL

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(2012) Arie Hoogendijk et al.   MOLECULAR MEDICINE

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis

(2012) Keqing Wang et al.   PLoS One

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective efferocytosis by alveolar macrophages in IPF patients

(2012) Konosuke Morimoto et al.   RESPIRATORY MEDICINE

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

(2011) D. Mahadevan et al.   ANNALS OF ONCOLOGY

Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9

(2011) Nina Berberich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance

(2011) N. Farahi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

(2011) Emmet E. McGrath et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Two-Step Engulfment of Apoptotic Cells

(2011) S. Toda et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

(2011) Ana L. Alessandri et al.   PLoS One

Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells

(2010) A. Weigert et al.   BLOOD

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

(2010) Andrew E. Leitch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cyclin-dependent kinases (cdks) and the DNA damage response: rationale for cdk inhibitor–chemotherapy combinations as an anticancer strategy for solid tumors

(2010) Neil Johnson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting granulocyte apoptosis: mechanisms, models, and therapies

(2010) Rodger Duffin et al.   IMMUNOLOGICAL REVIEWS

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

(2010) A. A. Filardy et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Apoptosis: Regulation of Tolerance versus Immunity

(2010) R. Kushwah et al.   JOURNAL OF IMMUNOLOGY

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

(2010) Sarah Fox et al.   Journal of Innate Immunity

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models

(2010) Bénédicte Menn et al.   PLoS One

N-Acetylcysteine Inhibits RhoA and Promotes Apoptotic Cell Clearance during Intense Lung Inflammation

(2009) Changsuk Moon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

(2009) AE Leitch et al.   BRITISH JOURNAL OF PHARMACOLOGY

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

(2009) Rodger Duffin et al.   FEBS LETTERS

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

(2009) Catherine A. Loynes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

(2009) Hsin-Ni Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Neutrophil secretion products pave the way for inflammatory monocytes

(2008) O. Soehnlein et al.   BLOOD

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

(2008) Rebecca C. Furze et al.   FASEB JOURNAL

Roscovitine Reduces Neuronal Loss, Glial Activation, and Neurologic Deficits after Brain Trauma

(2008) Genell D Hilton et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

(2008) Irini Bournazou et al.   JOURNAL OF CLINICAL INVESTIGATION

Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa

(2008) A E Leitch et al.   Mucosal Immunology

Prolonged survival of neutrophils from patients with  F508 CFTR mutations

(2008) D J McKeon et al.   THORAX

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

(2008) John M. Hallett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES