Eosinophils in the Lung – Modulating Apoptosis and Efferocytosis in Airway Inflammation

Bronchiectasis: an update on current pharmacotherapy and future perspectives

(2014) Manjit K Sidhu et al.   EXPERT OPINION ON PHARMACOTHERAPY

IgE-mediated mast cell responses are inhibited by thymol-mediated, activation-induced cell death in skin inflammation

(2014) Joshua B. Wechsler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation

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Swimming Against the Tide: Drugs Drive Neutrophil Reverse Migration

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A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

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Eosinophil Apoptosis as a Therapeutic Target in Allergic Asthma

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Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

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Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids

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Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

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Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

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Mechanisms regulating neutrophil survival and cell death

(2013) María Laura Gabelloni et al.   Seminars in Immunopathology

Resolvins as new fascinating drug candidates for inflammatory diseases

(2012) Chang Hoon Lee   ARCHIVES OF PHARMACAL RESEARCH

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

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Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

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Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

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Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

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Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury

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Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

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Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

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The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

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TAM receptor signaling and autoimmune disease

(2010) Carla V Rothlin et al.   CURRENT OPINION IN IMMUNOLOGY

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

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Targeting granulocyte apoptosis: mechanisms, models, and therapies

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The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Live and let die: is neutrophil apoptosis defective in severe asthma?

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Neutrophil kinetics in health and disease

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Eosinophil Survival and Apoptosis in Health and Disease

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Thymic Stromal Lymphopoietin Induces Chemotactic and Prosurvival Effects in Eosinophils

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Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

(2009) AE Leitch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Are we ready to downregulate mast cells?

(2009) Laila Karra et al.   CURRENT OPINION IN IMMUNOLOGY

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

(2009) Rodger Duffin et al.   FEBS LETTERS

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils

(2009) Emily P. Dick et al.   IMMUNOLOGY

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

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The effects of anti-asthma drugs on the phagocytic clearance of apoptotic eosinophils by A549 cells

(2009) Jiong Wang et al.   RESPIRATORY MEDICINE

Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils

(2008) N. Zimmermann et al.   ALLERGY

Eosinophils: Biological Properties and Role in Health and Disease

(2008) SIMON P. HOGAN et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils

(2008) Maho Suzukawa et al.   LABORATORY INVESTIGATION

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

(2008) Oliver Haworth et al.   NATURE IMMUNOLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE