Key mechanisms governing resolution of lung inflammation

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

(2016) Simon D. Pouwels et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus

(2016) Matthew G. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

(2016) Aleksander M. Grabiec et al.   Seminars in Immunopathology

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation

(2015) Christopher D. Lucas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

(2015) Bartomeu Colom et al.   IMMUNITY

Defining the phenotype of neutrophils following reverse migration in zebrafish

(2015) Felix Ellett et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of neutrophilic inflammation in lung injury induced by community-acquired pneumonia

(2015) Ricardo José et al.   LANCET

Macrolide Use and Neutrophil Function/Cytokine Levels in Hospitalized Patients with Community-Acquired Pneumonia: A Pilot Study

(2015) Forest W. Arnold et al.   LUNG

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients

(2015) Frauke Pedersen et al.   RESPIRATORY MEDICINE

New insights into the resolution of inflammation

(2015) Derek Gilroy et al.   SEMINARS IN IMMUNOLOGY

Macrophage development and polarization in chronic inflammation

(2015) Madhur P. Motwani et al.   SEMINARS IN IMMUNOLOGY

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation

(2015) A C Reis et al.   Cell Death & Disease

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

Autophagy in lung disease pathogenesis and therapeutics

(2015) Stefan W. Ryter et al.   Redox Biology

Evidence for a Cystic Fibrosis Enteropathy

(2015) Marlou P. M. Adriaanse et al.   PLoS One

Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation

(2014) Danielle Y. Qing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Overexpression of activated protein C hampers bacterial dissemination during pneumococcal pneumonia

(2014) Johannes Daan de Boer et al.   BMC INFECTIOUS DISEASES

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

NADPH Oxidase Promotes Neutrophil Extracellular Trap Formation in Pulmonary Aspergillosis

(2014) Marc Röhm et al.   INFECTION AND IMMUNITY

Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration

(2014) Sebastien Tauzin et al.   JOURNAL OF CELL BIOLOGY

Lipoxin A4 Counterregulates GM-CSF Signaling in Eosinophilic Granulocytes

(2014) V. Starosta et al.   JOURNAL OF IMMUNOLOGY

Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

(2014) Markryan Dwyer et al.   Journal of Innate Immunity

Lipoxin B4 promotes the resolution of allergic inflammation in the upper and lower airways of mice

(2014) L Karra et al.   Mucosal Immunology

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Swimming Against the Tide: Drugs Drive Neutrophil Reverse Migration

(2014) C. D. Lucas et al.   Science Translational Medicine

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

(2014) A. L. Robertson et al.   Science Translational Medicine

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

(2014) Calum T. Robb et al.   Nature Communications

The Regulation of Autophagy by Influenza A Virus

(2014) Rong Zhang et al.   Biomed Research International

Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial

(2014) Pallavi Mandal et al.   Lancet Respiratory Medicine

Eosinophils in the Lung – Modulating Apoptosis and Efferocytosis in Airway Inflammation

(2014) Jennifer M. Felton et al.   Frontiers in Immunology

Epidemiology of Nontuberculous Mycobacterial Infections and Associated Chronic Macrolide Use among Persons with Cystic Fibrosis

(2013) Alison M. Binder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Resolution of Acute Inflammation in the Lung

(2013) Bruce D. Levy et al.   Annual Review of Physiology

Eosinophil Apoptosis as a Therapeutic Target in Allergic Asthma

(2013) Pinja Ilmarinen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

(2013) S. Ueki et al.   BLOOD

Efferocytosis and Lung Disease

(2013) Alexandra L. McCubbrey et al.   CHEST

Alveolar macrophages in pulmonary host defence- the unrecognised role of apoptosis as a mechanism of intracellular bacterial killing

(2013) Jody Aberdein et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

The immunomodulatory effects of statins in community-acquired pneumonia: A systematic review

(2013) D.P.R. Troeman et al.   JOURNAL OF INFECTION

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

(2013) Robert D Gray et al.   Journal of Inflammation-London

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

(2013) John A. Marwick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Whatˈs your age again? Determination of human neutrophil half-lives revisited

(2013) Tamar Tak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

(2013) C D Lucas et al.   Mucosal Immunology

Natural resolution of inflammation

(2013) Marcelo O. Freire et al.   PERIODONTOLOGY 2000

Resolution of inflammation: Mechanisms and opportunity for drug development

(2013) Ana L. Alessandri et al.   PHARMACOLOGY & THERAPEUTICS

Use of antiplatelet agents in sepsis: A glimpse into the future

(2013) Karolina Akinosoglou et al.   THROMBOSIS RESEARCH

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

(2012) Lucy V. Norling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Macrolides for Acute Lung Injury

(2012) Michael J. Noto et al.   CHEST

Resolution of Inflammation in Asthma

(2012) Bruce D. Levy et al.   CLINICS IN CHEST MEDICINE

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

(2012) Christopher D. Lucas et al.   FASEB JOURNAL

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 and Aspirin-Triggered Resolvin D1 Promote Resolution of Allergic Airways Responses

(2012) A. P. Rogerio et al.   JOURNAL OF IMMUNOLOGY

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2012) Arie Hoogendijk et al.   MOLECULAR MEDICINE

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice

(2012) Ye-Ji Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Knotting the NETs: Analyzing histone modifications in neutrophil extracellular traps

(2012) Indira Neeli et al.   ARTHRITIS RESEARCH & THERAPY

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrolide Antibiotics and Survival in Patients With Acute Lung Injury

(2011) Allan J. Walkey et al.   CHEST

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance

(2011) N. Farahi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases

(2011) P. Zarogoulidis et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Increased lung neutrophil apoptosis and inflammation resolution in nonresponding pneumonia

(2011) I. Moret et al.   EUROPEAN RESPIRATORY JOURNAL

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

(2011) Ryszard Dworski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

CD103+pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

(2011) A. Nicole Desch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-  and IL-6 and Promote Cigarette Smoke-Induced Emphysema

(2011) Z. Xiong et al.   JOURNAL OF IMMUNOLOGY

NK Cells Are Effectors for Resolvin E1 in the Timely Resolution of Allergic Airway Inflammation

(2011) O. Haworth et al.   JOURNAL OF IMMUNOLOGY

Cleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic "Find-Me" Signal

(2011) K. E. Blume et al.   JOURNAL OF IMMUNOLOGY

Lung dendritic cells at the innate-adaptive immune interface

(2011) Tracy Voss Condon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Two-Step Engulfment of Apoptotic Cells

(2011) S. Toda et al.   MOLECULAR AND CELLULAR BIOLOGY

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis

(2011) Stéphane Jouneau et al.   PLoS One

Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

(2011) Robert L. Young et al.   PLoS One

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

(2011) Ana L. Alessandri et al.   PLoS One

The role of mast cells in allergic inflammation

(2011) Kawa Amin   RESPIRATORY MEDICINE

Progression of early structural lung disease in young children with cystic fibrosis assessed using CT

(2011) Lauren S Mott et al.   THORAX

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1

(2011) G Polier et al.   Cell Death & Disease

Epithelial repair mechanisms in the lung

(2010) Lynn M. Crosby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decoding Cell Death Signals in Inflammation and Immunity

(2010) Laurence Zitvogel et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane

(2010) Z T Schug et al.   CELL DEATH AND DIFFERENTIATION

The Changing Microbial Epidemiology in Cystic Fibrosis

(2010) J. J. LiPuma   CLINICAL MICROBIOLOGY REVIEWS

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

(2010) Marisa Ponpuak et al.   IMMUNITY

Targeting granulocyte apoptosis: mechanisms, models, and therapies

(2010) Rodger Duffin et al.   IMMUNOLOGICAL REVIEWS

Extracellular DNA: A Major Proinflammatory Component of Pseudomonas aeruginosa Biofilms

(2010) J. I. Fuxman Bass et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

(2010) Sarah Fox et al.   Journal of Innate Immunity

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation?

(2010) C. Persson et al.   THORAX

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

(2009) M. Nakayama et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis*

(2009) Benjamin M. P. Tang et al.   CRITICAL CARE MEDICINE

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

(2009) Rodger Duffin et al.   FEBS LETTERS

Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake

(2009) Jeffrey et al.   Frontiers in Bioscience-Landmark

Natural killer cells in infection and inflammation of the lung

(2009) Fiona J. Culley   IMMUNOLOGY

Inhibition of eosinophil migration by lactoferrin

(2009) Irini Bournazou et al.   IMMUNOLOGY AND CELL BIOLOGY

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

Regulation of Extracellular Chromatin Release from Neutrophils

(2009) Indira Neeli et al.   Journal of Innate Immunity

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

(2008) William J. Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Effects of Telithromycin in In Vitro and In Vivo Models of Lipopolysaccharide-Induced Airway Inflammation*

(2008) Magdalena Leiva et al.   CHEST

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

Thymosin β4 is involved in stabilin-2-mediated apoptotic cell engulfment

(2008) Sung-Jin Lee et al.   FEBS LETTERS

Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment

(2008) Seung-Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

(2008) Irini Bournazou et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relationship between Inhaled Corticosteroid Therapy and Rate of Lung Function Decline in Children with Cystic Fibrosis

(2008) Clement L. Ren et al.   JOURNAL OF PEDIATRICS

Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa

(2008) A E Leitch et al.   Mucosal Immunology

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

(2008) Oliver Haworth et al.   NATURE IMMUNOLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

ETosis: A Novel Cell Death Pathway

(2008) F. Wartha et al.   Science Signaling

Montelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: a systematic review

(2008) S Joos et al.   THORAX

Neutrophil extracellular traps are induced by Mycobacterium tuberculosis

(2008) Victoria Ramos-Kichik et al.   TUBERCULOSIS

Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis

(2008) John Victor Peter et al.   BMJ-British Medical Journal

Phagocytic clearance of apoptotic cells: role in lung disease

(2008) Jeong H Yun et al.   Expert Review of Respiratory Medicine

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus

(2007) C N Serhan et al.   BRITISH JOURNAL OF PHARMACOLOGY