3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

(2018) Xuanyi Ma et al.   ADVANCED DRUG DELIVERY REVIEWS

Applications of Bioengineered 3D Tissue and Tumor Organoids in Drug Development and Precision Medicine: Current and Future

(2018) Mahesh Devarasetty et al.   BIODRUGS

Engineering innervated secretory epithelial organoids by magnetic three-dimensional bioprinting for stimulating epithelial growth in salivary glands

(2018) Christabella Adine et al.   BIOMATERIALS

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening

(2018) Andrea R. Mazzocchi et al.   Scientific Reports

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

(2018) Shurong Hou et al.   SLAS Discovery

RGD-functionalized polyethylene glycol hydrogels support proliferation and in vitro chondrogenesis of human periosteum-derived cells

(2017) Abhijith K. Kudva et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Optimizing Human Induced Pluripotent Stem Cell Expansion in Stirred-Suspension Culture

(2017) Guoliang Meng et al.   STEM CELLS AND DEVELOPMENT

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Rapid Continuous Multimaterial Extrusion Bioprinting

(2016) Wanjun Liu et al.   ADVANCED MATERIALS

A Generalizable Strategy for the 3D Bioprinting of Hydrogels from Nonviscous Photo-crosslinkable Inks

(2016) Liliang Ouyang et al.   ADVANCED MATERIALS

Advanced Bioinks for 3D Printing: A Materials Science Perspective

(2016) David Chimene et al.   ANNALS OF BIOMEDICAL ENGINEERING

Current advances and future perspectives in extrusion-based bioprinting

(2016) Ibrahim T. Ozbolat et al.   BIOMATERIALS

Drop-on-demand inkjet-based cell printing with 30-μm nozzle diameter for cell-level accuracy

(2016) Young Kwon Kim et al.   Biomicrofluidics

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

(2016) Hyun-Wook Kang et al.   NATURE BIOTECHNOLOGY

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer

(2016) Yinghong Pan et al.   Oncotarget

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

(2016) Aleksander Skardal et al.   Jove-Journal of Visualized Experiments

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

(2016) Deborah G. Nguyen et al.   PLoS One

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs

(2015) Aleksander Skardal et al.   Acta Biomaterialia

Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

(2015) Cristina Colosi et al.   ADVANCED MATERIALS

3-dimensional bioprinting makes its mark: New tissue and organ printing methods are yielding critical new tools for the laboratory and clinic

(2015) Bryn Nelson   CANCER CYTOPATHOLOGY

Modes of cancer cell invasion and the role of the microenvironment

(2015) Andrew G Clark et al.   CURRENT OPINION IN CELL BIOLOGY

Precision Medicine — Personalized, Problematic, and Promising

(2015) J. Larry Jameson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Dynamic phototuning of 3D hydrogel stiffness

(2015) Ryan S. Stowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

(2015) Ana Perestrelo et al.   SENSORS

To Cross-Link or Not to Cross-Link? Cross-Linking Associated Foreign Body Response of Collagen-Based Devices

(2015) Luis M. Delgado et al.   TISSUE ENGINEERING PART B-REVIEWS

Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels

(2015) T. J. Hinton et al.   Science Advances

Peptide Hydrogels – Versatile Matrices for 3D Cell Culture in Cancer Medicine

(2015) Peter Worthington et al.   Frontiers in Oncology

Hydrogel: Preparation, characterization, and applications: A review

(2015) Enas M. Ahmed   Journal of Advanced Research

Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments

(2014) Anna Astashkina et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomaterials for Integration with 3-D Bioprinting

(2014) Aleksander Skardal et al.   ANNALS OF BIOMEDICAL ENGINEERING

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

(2014) Sreenivasa C. Ramaiahgari et al.   ARCHIVES OF TOXICOLOGY

In vitro platforms for evaluating liver toxicity

(2014) Shyam Sundhar Bale et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human periosteal-derived cell expansion in a perfusion bioreactor system: proliferation, differentiation and extracellular matrix formation

(2014) M. Sonnaert et al.   Journal of Tissue Engineering and Regenerative Medicine

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels

(2014) Luiz E Bertassoni et al.   Biofabrication

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

(2014) Falguni Pati et al.   Nature Communications

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

(2013) Jennifer N. Beck et al.   BIOMATERIALS

Physiologically relevant organs on chips

(2013) Kyungsuk Yum et al.   Biotechnology Journal

Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

(2013) Yoshiki Sasai   Cell Stem Cell

Laser Assisted Cell Printing

(2013) L. Koch et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cellular behavior in micropatterned hydrogels by bioprinting system depended on the cell types and cellular interaction

(2013) Soyoung Hong et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Light-assisted direct-write of 3D functional biomaterials

(2013) Kolin C. Hribar et al.   LAB ON A CHIP

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

A high-throughput three-dimensional cell migration assay for toxicity screening with mobile device-based macroscopic image analysis

(2013) David M. Timm et al.   Scientific Reports

High-Throughput Printing via Microvascular Multinozzle Arrays

(2012) Christopher J. Hansen et al.   ADVANCED MATERIALS

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function

(2012) Aleksander Skardal et al.   BIOMATERIALS

Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions

(2012) Masumi Yamada et al.   BIOMATERIALS

Drug discovery in pharmaceutical industry: productivity challenges and trends

(2012) Ish Khanna   DRUG DISCOVERY TODAY

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Evaluation of hydrogels for bio-printing applications

(2012) Sean V. Murphy et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

(2011) M. Ehrbar et al.   BIOPHYSICAL JOURNAL

A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform

(2011) Feng Xu et al.   Biotechnology Journal

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

(2011) Sean M. Wu et al.   NATURE CELL BIOLOGY

Scalable expansion of human pluripotent stem cells in suspension culture

(2011) Robert Zweigerdt et al.   Nature Protocols

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Predictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy

(2010) Rebecca C. Auer et al.   CANCER

Laser-assisted cell printing: principle, physical parameters versus cell fate and perspectives in tissue engineering

(2010) Fabien Guillemot et al.   Nanomedicine

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

High-throughput laser printing of cells and biomaterials for tissue engineering

(2009) F. Guillemot et al.   Acta Biomaterialia

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D

(2009) Fitzroy J. Byfield et al.   JOURNAL OF BIOMECHANICS

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY