Applications of Bioengineered 3D Tissue and Tumor Organoids in Drug Development and Precision Medicine: Current and Future

Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance

(2017) Hiroko Izumi-Nakaseko et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineered Submucosal Organoids for In Vitro Modeling of Colorectal Cancer

(2017) Mahesh Devarasetty et al.   TISSUE ENGINEERING PART A

Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

(2017) Vincenzo Prestigiacomo et al.   PLoS One

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Spatiotemporal control of cardiac anisotropy using dynamic nanotopographic cues

(2016) Paulos Y. Mengsteab et al.   BIOMATERIALS

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Physiologically relevant human tissue models for infectious diseases

(2016) Melody Mills et al.   DRUG DISCOVERY TODAY

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology

(2016) Daniel B. Deegan et al.   Journal of the Mechanical Behavior of Biomedical Materials

Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production

(2016) Alberto Purwada et al.   Nature Protocols

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

(2016) Weijie Peng et al.   TRENDS IN BIOTECHNOLOGY

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

Characterization of a functional C3A liver spheroid model

(2016) Harriet Gaskell et al.   Toxicology Research

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs

(2015) Aleksander Skardal et al.   Acta Biomaterialia

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Ex vivo engineered immune organoids for controlled germinal center reactions

(2015) Alberto Purwada et al.   BIOMATERIALS

Translating genomic discoveries to the clinic in pediatric oncology

(2015) Julia Glade Bender et al.   CURRENT OPINION IN PEDIATRICS

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Translational value of mouse models in oncology drug development

(2015) Stephen E Gould et al.   NATURE MEDICINE

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Precision Medicine — Personalized, Problematic, and Promising

(2015) J. Larry Jameson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes

(2015) Philippe Beauchamp et al.   TISSUE ENGINEERING PART C-METHODS

Organoid modeling for cancer precision medicine

(2015) Michael A Cantrell et al.   Genome Medicine

Effects of KATPopeners on the QT prolongation induced by HERG-blocking drugs in guinea-pigs

(2015) Lara Testai et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments

(2014) Anna Astashkina et al.   ADVANCED DRUG DELIVERY REVIEWS

Facile One-Step Micropatterning Using Photodegradable Gelatin Hydrogels for Improved Cardiomyocyte Organization and Alignment

(2014) Kelly M. C. Tsang et al.   ADVANCED FUNCTIONAL MATERIALS

Prioritizing targets for precision cancer medicine

(2014) F. Andre et al.   ANNALS OF ONCOLOGY

Translating Genomics for Precision Cancer Medicine

(2014) Roychowdhury Sameek et al.   Annual Review of Genomics and Human Genetics

Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes

(2014) Max R. Salick et al.   BIOMATERIALS

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Organoid cultures for the analysis of cancer phenotypes

(2014) Norman Sachs et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2014) Jun Lu et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

(2013) Jennifer N. Beck et al.   BIOMATERIALS

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue

(2013) V. R. Parasa et al.   Disease Models & Mechanisms

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Hydrogel-coated microfluidic channels for cardiomyocyte culture

(2013) Nasim Annabi et al.   LAB ON A CHIP

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

Micropatterned co-culture of hepatocyte spheroids layered on non-parenchymal cells to understand heterotypic cellular interactions

(2013) Hidenori Otsuka et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level

(2013) Zhen Ma et al.   Light-Science & Applications

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function

(2012) Aleksander Skardal et al.   BIOMATERIALS

Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions

(2012) Masumi Yamada et al.   BIOMATERIALS

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Modulation of alignment, elongation and contraction of cardiomyocytes through a combination of nanotopography and rigidity of substrates

(2011) Peng-Yuan Wang et al.   Acta Biomaterialia

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

(2011) Sean M. Wu et al.   NATURE CELL BIOLOGY

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology

(2011) Sebastian Schaaf et al.   PLoS One

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

(2011) Thomas Boudou et al.   TISSUE ENGINEERING PART A

Review Series: Aspects of Interstitial lung disease: Connective tissue disease-associated interstitial lung disease: How does it differ from IPF? How should the clinical approach differ?

(2011) Angelo de Lauretis et al.   Chronic Respiratory Disease

The generation of 3-D tissue models based on hyaluronan hydrogel-coated microcarriers within a rotating wall vessel bioreactor

(2010) Aleksander Skardal et al.   BIOMATERIALS

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

(2010) Chengqun Huang et al.   CIRCULATION

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

(2010) Xonia Carvajal-Vergara et al.   NATURE

Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions

(2010) Jennifer Barrila et al.   NATURE REVIEWS MICROBIOLOGY

Engineered Heart Tissue: A Novel Tool to Study the Ischemic Changes of the Heart In Vitro

(2010) Rajesh G. Katare et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs

(2009) D.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leopard syndrome

(2008) Anna Sarkozy et al.   Orphanet Journal of Rare Diseases

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT

Microfluidics for drug discovery and development: From target selection to product lifecycle management

(2007) L KANG   DRUG DISCOVERY TODAY