miR‐146a‐5p: Expression, regulation, and functions in cancer

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

(2018) Shan-shan Zhou et al.   ACTA PHARMACOLOGICA SINICA

miR-146a targets c-met and abolishes colorectal cancer liver metastasis

(2018) Anne-Marie Bleau et al.   CANCER LETTERS

miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP)

(2018) Wenfeng Tan et al.   CANCER LETTERS

Identification of miR-146a is Associated with the Aggressiveness and Suppresses Proliferation via Targeting CDKN2A in Breast Cancer

(2018) Yanping Zhang et al.   PATHOLOGY & ONCOLOGY RESEARCH

CTBP1 and metabolic syndrome induce an mRNA and miRNA expression profile critical for breast cancer progression and metastasis

(2018) Paula L. Farré et al.   Oncotarget

Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer

(2018) Gati K. Panigrahi et al.   Oncotarget

Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment

(2018) Aparna Karthikeyan et al.   Oncotarget

miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells

(2018) Joseph R. Iacona et al.   Oncotarget

p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells

(2018) Liang Zhong et al.   Scientific Reports

Long non-coding RNA NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a

(2018) Yun-xiao Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MicroRNA-146a-5p Enhances Radiosensitivity in Hepatocellular Carcinoma through Replication Protein A3 Induced Activation of the DNA Repair Pathway

(2018) Jing Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased expression of long non-coding RNA SNHG16 correlates with tumor progression and poor prognosis in non-small cell lung cancer

(2018) Wei Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Extracellular vesicles as a source for non-invasive biomarkers in bladder cancer progression

(2017) Zoraida Andreu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Down-regulation of microRNA-146a is associated with high-risk human papillomavirus infection and epidermal growth factor receptor overexpression in penile squamous cell carcinoma

(2017) Elektra Peta et al.   HUMAN PATHOLOGY

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer

(2017) Yeqing Huang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNAs that affect the Fanconi Anemia/BRCA pathway are downregulated in imatinib-resistant chronic myeloid leukemia patients without detectable BCR-ABL kinase domain mutations

(2017) E Yap et al.   LEUKEMIA RESEARCH

MicroRNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor β-activated kinase 1

(2017) Yiming Chen et al.   Molecular Medicine Reports

miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma

(2017) Zhenwei Qiu et al.   ONCOLOGY REPORTS

miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers

(2017) Insaf Fkih M’hamed et al.   PATHOLOGY & ONCOLOGY RESEARCH

miR-146a–Traf6regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression

(2017) Nathaniel Magilnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of urinary miRNAs targeting NLRs inflammasomes in bladder cancer

(2017) Ettore Mearini et al.   OncoTargets and Therapy

Expression of miR-146a in patients with ovarian cancer and its clinical significance

(2017) Miłosz Wilczyński et al.   Oncology Letters

Identification of circulating microRNA signatures as potential noninvasive biomarkers for prediction and prognosis of lymph node metastasis in gastric cancer

(2017) Xiumei Jiang et al.   Oncotarget

Identification of A Panel of Serum microRNAs as Biomarkers for Early Detection of Lung Adenocarcinoma

(2017) Shaogang Lv et al.   Journal of Cancer

Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a

(2017) Qian Cheng et al.   Stem Cells International

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma

(2016) Cong Wang et al.   BRITISH JOURNAL OF CANCER

miR-146a-5p mediates epithelial–mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2

(2016) Cong Wang et al.   BRITISH JOURNAL OF CANCER

Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity

(2016) Kim De Veirman et al.   CANCER LETTERS

Direct Comparison of Metastasis-Related miRNAs Expression Levels in Circulating Tumor Cells, Corresponding Plasma, and Primary Tumors of Breast Cancer Patients

(2016) A. Markou et al.   CLINICAL CHEMISTRY

Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection

(2016) Hideo Sasaki et al.   Clinical Genitourinary Cancer

Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis

(2016) Simonetta Bandiera et al.   JOURNAL OF VIROLOGY

miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization

(2016) M. Raimo et al.   MOLECULAR CANCER RESEARCH

MicroRNA-146a inhibits cell migration and invasion by targeting RhoA in breast cancer

(2016) QIN LIU et al.   ONCOLOGY REPORTS

miR-146a Inhibits Proliferation and Enhances Chemosensitivity in Epithelial Ovarian Cancer via Reduction of SOD2

(2016) YaJie Cui et al.   ONCOLOGY RESEARCH

Family of microRNA-146 Regulates RARβ in Papillary Thyroid Carcinoma

(2016) Agnieszka Anna Czajka et al.   PLoS One

MicroRNA-146a affects the chemotherapeutic sensitivity and prognosis of advanced gastric cancer through the regulation of LIN52

(2016) Zhifen Luo et al.   Oncology Letters

LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR-146a

(2016) Hong-tao Liu et al.   Cancer Medicine

Integrated microRNA and mRNA Signature Associated with the Transition from the Locally Confined to the Metastasized Clear Cell Renal Cell Carcinoma Exemplified by miR-146-5p

(2016) Zofia Wotschofsky et al.   PLoS One

Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma

(2015) Zonggao Shi et al.   ARCHIVES OF ORAL BIOLOGY

Associations of miR-146a and miR-146b expression and clinical characteristics in papillary thyroid carcinoma

(2015) Mei Sun et al.   Cancer Biomarkers

FOXP3 Controls an miR-146/NF- B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells

(2015) R. Liu et al.   CANCER RESEARCH

FOXP3-miR-146-NF- B Axis and Therapy for Precancerous Lesions in Prostate

(2015) R. Liu et al.   CANCER RESEARCH

Combinatorial Action of MicroRNAslet-7and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation

(2015) Carlos Stahlhut et al.   CELL CYCLE

miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression

(2015) Xiaoxia Sun et al.   CELL CYCLE

MicroRNA Expression Profiling and DNA Methylation Signature for Deregulated MicroRNA in Cutaneous T-Cell Lymphoma

(2015) Juan Sandoval et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumor necrosis factor–related apoptosis-inducing ligand induces the expression of proinflammatory cytokines in macrophages and re-educates tumor-associated macrophages to an antitumor phenotype

(2015) Jing Gao et al.   MOLECULAR BIOLOGY OF THE CELL

microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma

(2015) Zheng Zhang et al.   Molecular Cancer

Induction of microRNA-146a is involved in curcumin-mediated enhancement of temozolomide cytotoxicity against human glioblastoma

(2015) HAO WU et al.   Molecular Medicine Reports

Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1

(2015) Bin Xu et al.   PROSTATE

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1

(2015) Jorge R. Contreras et al.   Oncotarget

Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients

(2015) Isabel Stückrath et al.   Oncotarget

The emerging role of microRNAs in Alzheimer's disease

(2015) Grazia D. Femminella et al.   Frontiers in Physiology

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

Demethylation of the miR-146a promoter by 5-Aza-2’-deoxycytidine correlates with delayed progression of castration-resistant prostate cancer

(2014) Xiaolu Wang et al.   BMC CANCER

Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling

(2014) Shadan Ali et al.   CANCER LETTERS

Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status

(2014) Rupninder Sandhu et al.   CARCINOGENESIS

Regulation of Activation-associated MicroRNA Accumulation Rates during Monocyte-to-macrophage Differentiation

(2014) Renee L. Eigsti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function

(2014) E Kumaraswamy et al.   ONCOGENE

miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1

(2014) Qian Sun et al.   PROSTATE

Regulation of COX-2 expression by miR-146a in lung cancer cells

(2014) Ashley L. Cornett et al.   RNA

Serum Levels of miR-19b and miR-146a as Prognostic Biomarkers for Non-Small Cell Lung Cancer

(2014) Chaohui Wu et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

(2014) Matteo Forloni et al.   eLife

MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response

(2014) Reuben Saba et al.   Frontiers in Immunology

EZH2: biology, disease and structure-based drug discovery

(2013) Jin-zhi Tan et al.   ACTA PHARMACOLOGICA SINICA

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes

(2013) S U Lauvrak et al.   BRITISH JOURNAL OF CANCER

MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2

(2013) Qunyan Yao et al.   CANCER LETTERS

MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression

(2013) Kai Zhu et al.   CARCINOGENESIS

Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis

(2013) Lin Zhou et al.   FASEB JOURNAL

MicroRNA-146a targets PRKCE to modulate papillary thyroid tumor development

(2013) Xiaoping Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Validation of Circulating miRNA Biomarkers for Predicting Lymph Node Metastasis in Gastric Cancer

(2013) Shine Young Kim et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Emerging Roles of Competing Endogenous RNAs in Cancer: Insights from the Regulation of PTEN

(2013) A. de Giorgio et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of Ovarian Cancer Metastatic miRNAs

(2013) Souriya Vang et al.   PLoS One

miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells

(2013) Gang Chen et al.   PLoS One

miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes

(2013) Pei-Shi Hung et al.   PLoS One

Expression and clinicopathological significance of miR-146a in hepatocellular carcinoma tissues

(2013) Minhua Rong et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

(2013) Jimmy L Zhao et al.   eLife

The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer

(2012) Catherine Labbaye et al.   Journal of Hematology & Oncology

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

(2012) Stephanie Crone et al.   Molecular Cancer

microRNA-146a targets the L1 cell adhesion molecule and suppresses the metastatic potential of gastric cancer

(2012) ZHIBO HOU et al.   Molecular Medicine Reports

Mirtrons: microRNA biogenesis via splicing

(2011) Jakub O. Westholm et al.   BIOCHIMIE

Abstract 5703: Up-regulation of miR-146a contributes to the inhibition of invasion of pancreatic cancer cells

(2011) Yiwei Li et al.   CANCER RESEARCH

MicroRNA-146a Downregulates NF B Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma

(2011) J. H. Paik et al.   CLINICAL CANCER RESEARCH

Clinical Significance of miR-146a in Gastric Cancer Cases

(2011) R. Kogo et al.   CLINICAL CANCER RESEARCH

Down-regulation ofBRCA1expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers

(2011) Amandine I. Garcia et al.   EMBO Molecular Medicine

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis

(2011) Zhibo Hou et al.   MEDICAL ONCOLOGY

MicroRNA-146a Inhibits Glioma Development by Targeting Notch1

(2011) J. Mei et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance

(2011) Andreas Karakatsanis et al.   MOLECULAR CARCINOGENESIS

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

NF- B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies

(2011) J. L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in a p-ERK-dependent manner in castration-resistant prostate cancer

(2011) Bin Xu et al.   PROSTATE

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

miR-146a Suppresses Invasion of Pancreatic Cancer Cells

(2010) Y. Li et al.   CANCER RESEARCH

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

Breast Cancer Metastasis Suppressor 1 Up-regulates miR-146, Which Suppresses Breast Cancer Metastasis

(2009) Douglas R. Hurst et al.   CANCER RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells

(2009) Mariko Tomita et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA in autoimmunity and autoimmune diseases

(2009) Kaleb M. Pauley et al.   JOURNAL OF AUTOIMMUNITY

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

(2009) J. Hou et al.   JOURNAL OF IMMUNOLOGY

MicroRNA Patterns Associated with Clinical Prognostic Parameters and CNS Relapse Prediction in Pediatric Acute Leukemia

(2009) Hua Zhang et al.   PLoS One

SNPs in human miRNA genes affect biogenesis and function

(2009) G. Sun et al.   RNA

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells

(2008) D Bhaumik et al.   ONCOGENE

Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth

(2008) Xiaohong Wang et al.   PLoS One

Loss of mir-146a function in hormone-refractory prostate cancer

(2008) S.-L. Lin et al.   RNA

Penile cancer: epidemiology, pathogenesis and prevention

(2008) M. C. G. Bleeker et al.   WORLD JOURNAL OF UROLOGY