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Title
EZH2: biology, disease and structure-based drug discovery
Authors
Keywords
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Journal
ACTA PHARMACOLOGICA SINICA
Volume 35, Issue 2, Pages 161-174
Publisher
Springer Nature
Online
2013-12-23
DOI
10.1038/aps.2013.161
References
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- EZH2 Promotes E2F-Driven SCLC Tumorigenesis through Modulation of Apoptosis and Cell-Cycle Regulation
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- Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity
- (2013) X Zhao et al. LEUKEMIA
- Inner workings and regulatory inputs that control Polycomb repressive complex 2
- (2012) M. Maggie O’Meara et al. CHROMOSOMA
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- (2012) M. T. McCabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
- (2012) K. Xu et al. SCIENCE
- Molecular architecture of human polycomb repressive complex 2
- (2012) Claudio Ciferri et al. eLife
- Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer
- (2011) Qi Cao et al. CANCER CELL
- Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer
- (2011) M. E. Gonzalez et al. CANCER RESEARCH
- Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage
- (2011) Z Wu et al. CELL DEATH AND DIFFERENTIATION
- Cooperation between Polycomb and androgen receptor during oncogenic transformation
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- (2011) Shuet Theng Lee et al. MOLECULAR CELL
- Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks
- (2011) Frank W. Schmitges et al. MOLECULAR CELL
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- (2011) Ryan D. Morin et al. NATURE
- EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
- (2010) I. Velichutina et al. BLOOD
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- Androgens Suppress EZH2 Expression Via Retinoblastoma (RB) and p130-Dependent Pathways: A Potential Mechanism of Androgen-Refractory Progression of Prostate Cancer
- (2010) Laura R. Bohrer et al. ENDOCRINOLOGY
- Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex
- (2010) Sara Lejon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Structural Biology of Human H3K9 Methyltransferases
- (2010) Hong Wu et al. PLoS One
- Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
- (2010) C. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dimerization of a viral SET protein endows its function
- (2010) H. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells
- (2009) F. Sun et al. MOLECULAR CANCER THERAPEUTICS
- Role of the polycomb protein EED in the propagation of repressive histone marks
- (2009) Raphael Margueron et al. NATURE
- Protein methyltransferases as a target class for drug discovery
- (2009) Robert A. Copeland et al. NATURE REVIEWS DRUG DISCOVERY
- Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
- (2009) Yanqi Chang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Chemical mechanisms of histone lysine and arginine modifications
- (2008) Brian C. Smith et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Roles of the EZH2 histone methyltransferase in cancer epigenetics
- (2008) Jeffrey A. Simon et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases
- (2008) X. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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