Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Selective mitochondrial DNA degradation following double-strand breaks

(2017) Amandine Moretton et al.   PLoS One

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

(2016) Mitsutoshi Yamada et al.   Cell Stem Cell

Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics

(2016) Hideyuki Hatakeyama et al.   STEM CELLS

Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging

(2016) Eirini Lionaki et al.   Frontiers in Genetics

Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

(2015) Pradeep Reddy et al.   CELL

Metabolic rescue in pluripotent cells from patients with mtDNA disease

(2015) Hong Ma et al.   NATURE

Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels

(2015) Masaki Kodaira et al.   FEBS Open Bio

Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases

(2014) Tian Wang et al.   CELL

Mitochondrial DNA disease—molecular insights and potential routes to a cure

(2014) Oliver Russell et al.   EXPERIMENTAL CELL RESEARCH

FDA Considers Trials of 'Three-Parent Embryos'

(2014) G. Vogel   SCIENCE

A mitochondrial bioenergetic etiology of disease

(2013) Douglas C. Wallace   JOURNAL OF CLINICAL INVESTIGATION

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

(2013) Sandra R Bacman et al.   NATURE MEDICINE

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

(2013) R. H. Hamalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS

(2013) Clifford D.L. Folmes et al.   STEM CELLS

Mitochondrial disorders: aetiologies, models systems, and candidate therapies

(2013) G. Jane Farrar et al.   TRENDS IN GENETICS

Gene supplementation therapy for recessive forms of inherited retinal dystrophies

(2011) A J Smith et al.   GENE THERAPY

XanthomonasAvrBs3 Family-Type III Effectors: Discovery and Function

(2010) Jens Boch et al.   Annual Review of Phytopathology

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

(2010) S R Bacman et al.   GENE THERAPY

Identification and Characterization of Mitochondrial Targeting Sequence of Human Apurinic/Apyrimidinic Endonuclease 1

(2010) Mengxia Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes

(2008) M F Alexeyev et al.   GENE THERAPY