A review of pig liver xenotransplantation: Current problems and recent progress

Tissue Factor at the crossroad of coagulation and cell signaling

(2018) Hortensia Zelaya et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Xenotransplantation: back to the future?

(2018) Raphael P. H. Meier et al.   TRANSPLANT INTERNATIONAL

Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates

(2018) Liaoran Wang et al.   TRANSPLANTATION

B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen

(2018) Guerard Byrne et al.   XENOTRANSPLANTATION

The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation

(2018) Chengjiang Zhao et al.   XENOTRANSPLANTATION

Multiple genetically modified GTKO/hCD46/HLA-E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

(2018) Jan-Michael Abicht et al.   XENOTRANSPLANTATION

Is sensitization to pig antigens detrimental to subsequent allotransplantation?

(2018) Qi Li et al.   XENOTRANSPLANTATION

Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation

(2018) Tian-Fei Lu et al.   Immune Network

Assembling multiple xenoprotective transgenes in pigs

(2018) Konrad Fischer et al.   XENOTRANSPLANTATION

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

(2017) Michael Tanowitz et al.   NUCLEIC ACIDS RESEARCH

Generation of CMAHKO/GTKO/shTNFRI-Fc/HO-1 quadruple gene modified pigs

(2017) Geon A. Kim et al.   TRANSGENIC RESEARCH

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47

(2017) Aseda A. Tena et al.   TRANSPLANTATION

Effects of carbon monoxide on early dysfunction and microangiopathy following GalT-KO porcine pulmonary xenotransplantation in cynomolgus monkeys

(2017) Hisashi Sahara et al.   XENOTRANSPLANTATION

The role of sialic acids in the immune recognition of xenografts

(2017) Beth M. French et al.   XENOTRANSPLANTATION

Cytokine profiles in Tibetan macaques following α-1,3-galactosyltransferase-knockout pig liver xenotransplantation

(2017) Zhuochao Zhang et al.   XENOTRANSPLANTATION

Angiopoietin-1 and angiopoietin-2 protect porcine iliac endothelial cells from human antibody-mediated complement-dependent cytotoxicity through phosphatidylinositide 3-kinase/AKT pathway activation

(2017) Hanchao Gao et al.   XENOTRANSPLANTATION

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

(2017) Christopher T. Laird et al.   XENOTRANSPLANTATION

Synthetic liver function is detectable in transgenic porcine livers perfused with human blood

(2017) Arielle Cimeno et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model

(2017) Arielle Cimeno et al.   XENOTRANSPLANTATION

ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

(2017) Heidrun Degen et al.   Journal of the American Heart Association

Molecular adsorbent recirculating system (MARS) in acute liver injury and graft dysfunction: Results from a case-control study

(2017) Hans U. Gerth et al.   PLoS One

The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation

(2016) N. Navarro-Alvarez et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Bridge to Somewhere

(2016) Jigesh A. Shah et al.   ANNALS OF SURGERY

Lung xenotransplantation

(2016) Chris Laird et al.   Current Opinion in Organ Transplantation

Contact system revisited: an interface between inflammation, coagulation, and innate immunity

(2016) A. T. Long et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Physiology

(2016) Andrew Frelinger et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers

(2016) James Russell Butler et al.   TRANSPLANTATION

Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor

(2016) Lars Burdorf et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Endothelial cell control of thrombosis

(2015) Jonathan W. Yau et al.   BMC Cardiovascular Disorders

Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

(2015) Hongchen Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activated-platelet targeting of CD39 as a potential way forward

(2015) J. D. Hohmann et al.   Hamostaseologie

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs

(2015) H. Iwase et al.   TRANSPLANT IMMUNOLOGY

Functional Difference Between Membrane-bound and Soluble Human Thrombomodulin

(2015) Yuko Miwa et al.   TRANSPLANTATION

Porcine Extrahepatic Vascular Endothelial Asialoglycoprotein Receptor 1 Mediates Xenogeneic Platelet Phagocytosis In Vitro and in Human-to-Pig Ex Vivo Xenoperfusion

(2015) Anjan K. Bongoni et al.   TRANSPLANTATION

Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein

(2015) Leela L. Paris et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Current status of pig kidney xenotransplantation

(2015) Hayato Iwase et al.   International Journal of Surgery

Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation

(2015) Peter J. Cowan et al.   International Journal of Surgery

Four-Dimensional Characterization of Thrombosis in a Live-Cell, Shear-Flow Assay: Development and Application to Xenotransplantation

(2015) Donald G. Harris et al.   PLoS One

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

C1-esterase inhibitor treatment: preclinical safety aspects on the potential prothrombotic risk

(2014) Elmar Raquet et al.   THROMBOSIS AND HAEMOSTASIS

Transgenic expression of human cytoxic T-lymphocyte associated antigen4-Immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting

(2014) Yong Wang et al.   TRANSGENIC RESEARCH

A Human-Specific Mutation Limits Nonhuman Primate Efficacy in Preclinical Xenotransplantation Studies

(2014) Joshua P. Waldman et al.   TRANSPLANTATION

Increased transfusion-free survival following auxiliary pig liver xenotransplantation

(2014) Heidi Yeh et al.   XENOTRANSPLANTATION

Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade

(2014) John C. LaMattina et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

Porcine Sialoadhesin: A Newly Identified Xenogeneic Innate Immune Receptor

(2012) L. G. Brock et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immunobiology of liver xenotransplantation

(2012) Burcin Ekser et al.   Expert Review of Clinical Immunology

Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial

(2012) Rafael Bañares et al.   HEPATOLOGY

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

(2012) Burcin Ekser et al.   TRANSPLANT INTERNATIONAL

Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells

(2012) Corin Ezzelarab et al.   XENOTRANSPLANTATION

Clinical lung xenotransplantation - what donor genetic modifications may be necessary?

(2012) David K. C. Cooper et al.   XENOTRANSPLANTATION

Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons

(2012) Karen Kim et al.   XENOTRANSPLANTATION

Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitro

(2012) Leela L. Paris et al.   XENOTRANSPLANTATION

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Primary Porcine Kupffer Cell Phagocytosis of Human Platelets Involves the CD18 Receptor

(2011) Ray K. Chihara et al.   TRANSPLANTATION

ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro

(2011) Leela L. Paris et al.   XENOTRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells

(2010) C. C. LIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reference values for thromboelastometry (ROTEM®) in cynomolgus monkeys (Macaca fascicularis)

(2010) Luca Spiezia et al.   THROMBOSIS RESEARCH

Hepatic Function After Genetically Engineered Pig Liver Transplantation in Baboons

(2010) Burcin Ekser et al.   TRANSPLANTATION

The fate of human platelets perfused through the pig liver: implications for xenotransplantation

(2010) Christopher Burlak et al.   XENOTRANSPLANTATION

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation

(2009) C. Knosalla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

(2009) B. Ekser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Progress and prospects: genetic engineering in xenotransplantation

(2008) S Le Bas-Bernardet et al.   GENE THERAPY

Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation

(2008) Young Tae Kim et al.   XENOTRANSPLANTATION