Article
Biochemistry & Molecular Biology
Na Li, Yanhong Wang, Anqing Wang, Jing Zhang, Chaoran Jia, Chunlei Yu, Zhenbo Song, Shuyue Wang, Lei Liu, Jingwen Yi, Yongli Bao, Yanxin Huang, Luguo Sun
Summary: The protein phosphatases STS1 and STS2 negatively regulate the self-renewal and differentiation of hematopoietic stem and progenitor cells. Baicalein is identified as an effective inhibitor of STS1 and STS2, promoting the expansion and differentiation of HSPCs. Furthermore, baicalein restores the phosphorylation of FLT3 and cKIT and enhances the survival of mice with myelosuppression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
Summary: The study aimed to investigate the efficacy and tolerability of N-acetyl-L-cysteine (NAC) prophylaxis in reducing Poor Graft Function (PGF) or Prolonged Isolated Thrombocytopenia (PT) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The results showed that NAC prophylaxis effectively reduced the incidence of PGF and PT, and it was well tolerated in haploidentical HSCT.
Article
Multidisciplinary Sciences
Xia Chen, Peiliang Wang, Hui Qiu, Yonglin Zhu, Xingwu Zhang, Yaxuan Zhang, Fuyu Duan, Shuangyuan Ding, Jianying Guo, Yue Huang, Jie Na
Summary: This study provides a comprehensive analysis of the epigenetic landscape of human pluripotent stem cell hematopoietic differentiation and identifies JUNB as an essential transcription factor for hemogenic endothelium development.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Christina M. Termini, Amara Pang, Michelle Li, Tiancheng Fang, Vivian Y. Chang, John P. Chute
Summary: The discovery of Syndecan-2 as a novel surface marker and regulator of hematopoietic stem cell (HSC) function has improved the understanding of HSC identity and their capacity for repopulation. Syndecan-2 expression is significantly increased in long-term HSCs compared to differentiated hematopoietic cells. Isolation of bone marrow cells based on Syndecan-2 expression results in a higher enrichment of HSCs with superior in vivo repopulating capacity, compared to conventional selection methods. Syndecan-2 regulates HSC repopulating capacity through control of Cdkn1c expression and HSC quiescence.
Article
Nutrition & Dietetics
Yiding Wu, Weinian Liao, Jun Chen, Chaonan Liu, Shuzhen Zhang, Kuan Yu, Xinmiao Wang, Mo Chen, Song Wang, Xinze Ran, Yongping Su, Tianmin Cheng, Junping Wang, Changhong Du
Summary: In this study, the researchers investigated the impact of inorganic phosphate (Pi) metabolism on myelosuppression induced by radiation therapy. They found that Pi metabolism was acutely inhibited in hematopoietic stem cells (HSCs) during irradiation-induced myelosuppression, and this inhibition was closely correlated with the severity and prognosis of myelosuppression. The researchers also discovered that the inhibition of Pi metabolism weakened the ability of HSCs to counteract p53-mediated Pi metabolic inhibition, leading to the apoptosis of HSCs and the progression of myelosuppression. Moreover, the modulation of Pi metabolism in HSCs showed protective effects against radiation-induced myelosuppression.
Review
Chemistry, Multidisciplinary
Jie Fang, Zhi Wang, Chao-yu Miao
Summary: Stroke is the second leading cause of death globally due to its high disability and mortality rates. Currently, there are limited clinical treatment strategies available for stroke, with tissue plasminogen activator (tPA) being the only FDA-approved drug. Angiogenesis, which promotes neural regeneration and functional recovery, is an important protective mechanism during stroke. Thus, inducing angiogenesis in the affected area can improve hemodynamics and facilitate vascular remodeling and recovery of neurovascular function. This review summarizes the cellular and molecular mechanisms affecting angiogenesis after cerebral ischemia, and provides pro-angiogenic strategies for exploring the treatment of ischemic stroke, including endothelial progenitor cells, mesenchymal stem cells, growth factors, cytokines, non-coding RNAs, etc.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Wanrong Bao, Quanwei Zhang, Hongming Zheng, Lifeng Li, Man Liu, Huiyuan Cheng, Tinlong Wong, Ge Zhang, Aiping Lu, Zhaoxiang Bian, Diklung Ma, Chunghang Leung, Quanbin Han
Summary: Radix Astragali polysaccharide (RAP) directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression, demonstrating a significant protective effect in hematopoiesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Developmental Biology
Yukino Wada, Hikaru Tsukatani, Chihiro Kuroda, Yurika Miyazaki, Miku Otoshi, Isao Kobayashi
Summary: This study identifies a previously unknown spatiotemporal regulatory mechanism of hematopoietic stem cell specification by somites in zebrafish, in which Jag2b-induced Notch signaling leads to the expression of wnt16 and HSC markers.
Article
Biochemistry & Molecular Biology
Chaonan Liu, Weinian Liao, Jun Chen, Shuzhen Zhang, Mo Chen, Fang Chen, Tianmin Cheng, Junping Wang, Changhong Du
Summary: There is a growing understanding of the role of hematopoietic alterations in the detrimental effects of metabolic disorders. This study reveals that hematopoietic stem cells in the bone marrow have distinct cholesterol metabolic signatures and that cholesterol directly regulates their maintenance and lineage differentiation. The study also uncovers the mechanisms by which cholesterol enhances ferroptosis resistance and promotes myeloid lineage differentiation while dampening lymphoid lineage differentiation. These findings have important clinical implications for understanding and treating metabolic disorders.
Article
Immunology
Nicolaas G. van der Maas, Erik G. J. von Asmuth, Dagmar Berghuis, Pauline A. van Schouwenburg, Hein Putter, Mirjam van der Burg, Arjan C. Lankester
Summary: In the first year after hematopoietic stem cell transplantation (HSCT), donor and recipient age were identified as significant determinants for total and memory B-cell reconstitution. Stem cell source, donor type, and conditioning did not show significant correlations with B-cell numbers. Linear mixed effect modelling pinpointed donor and recipient age as independent determinants of B-cell reconstitution 0.5-2 years post-HSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jiayu Wang, Meng Yuan, Guanghua Zhu, Runhui Wu, Chenguang Jia, Bin Wang, Jie Zheng, Jie Ma, Maoquan Qin, Sidan Li
Summary: This study analyzed the immune reconstitution of pediatric patients with aplastic anemia after hematopoietic stem-cell transplantation (HSCT) and found that early rapid immune reconstitution is a good predictor of clinical prognosis in children with AA.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cell & Tissue Engineering
Zenghua Lin, Maile K. Hollinger, Zhijie Wu, Wanling Sun, Kaylind Batey, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young
Summary: It was found that sirolimus enhanced the regeneration of hematopoietic stem and progenitor cells in mice exposed to sublethal total body irradiation and other regenerative stressors. The effects were associated with increased expression of hematopoietic genes, reduced DNA damage and clearance of cellular reactive oxygen species. Sirolimus also showed potential clinical applications for the treatment and prevention of hematopoietic injury.
Article
Cell Biology
Kai Zhang, Huifang Zhao, Yaru Sheng, Xinyu Chen, Penghui Xu, Jinming Wang, Zhongzhong Ji, Yuman He, Wei-Qiang Gao, Helen He Zhu
Summary: The study reveals the important role of Zeb1 in regulating hematopoietic stem cell (HSC) stemness. Zeb1 acts as a transcriptional suppressor on mitochondrial fusion protein Mfn2, leading to fragmented mitochondrial morphology and low metabolic status. Zeb1(+)LSKs represent a subset of functional long-term HSCs.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Junhong Li, Zhaoxian Yu, Yingyi Jiang, Suihua Lao, Dexian Li
Summary: This is the first successful case of post-HSCT TB patients treated with contezolid-containing antibiotic management strategies, which exhibited remarkable efficacy and good safety in this deadly disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell & Tissue Engineering
Jianan Jiang, Jinhua Qin, Jisheng Li, Xiaosong Lin, Bowen Zhang, Zeng Fan, Lijuan He, Quan Zeng, Wen Yue, Min Zheng, Xuetao Pei, Yanhua Li
Summary: This study found that the small molecule Ricolinostat can promote the differentiation of megakaryocytic cells from HSPCs, increase the proliferation of megakaryocytic cells, and decrease the secretion of IL-8 and the expression of CXCR2, thereby improving the efficiency of megakaryocytic differentiation of HSPCs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Zhongwei Cao, Tinghong Ye, Yue Sun, Gaili Ji, Koji Shido, Yutian Chen, Lin Luo, Feifei Na, Xiaoyan Li, Zhen Huang, Jane L. Ko, Vivek Mittal, Lina Qiao, Chong Chen, Fernando J. Martinez, Shahin Rafii, Bi-Sen Ding
SCIENCE TRANSLATIONAL MEDICINE
(2017)