Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor

(2016) Colleen A. McGourty et al.   CELL

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15

(2016) Michol Giovanna Savio et al.   CURRENT BIOLOGY

Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle

(2016) Shijiao Huang et al.   DEVELOPMENTAL CELL

Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond

(2016) Baris Bingol et al.   FREE RADICAL BIOLOGY AND MEDICINE

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

(2016) Babita Madan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

(2016) Zoi Alexopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

(2016) Nicolas Huguenin-Dezot et al.   Cell Reports

A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes

(2016) Michaela Gschweitl et al.   eLife

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

(2016) Elsa Perrody et al.   eLife

The Pathway of Collagen Secretion

(2015) Vivek Malhotra et al.   Annual Review of Cell and Developmental Biology

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Recurrent gain-of-function USP8 mutations in Cushing's disease

(2015) Zeng-Yi Ma et al.   CELL RESEARCH

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOLNovelty and Significance

(2015) Jessica Kristine Nelson et al.   CIRCULATION RESEARCH

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

(2015) J.-R. Liang et al.   EMBO REPORTS

The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage

(2015) Nardeen Baiady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated ubiquitin chain is the genuine Parkin receptor

(2015) Kei Okatsu et al.   JOURNAL OF CELL BIOLOGY

The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking

(2015) Yuda Huo et al.   JOURNAL OF NEUROCHEMISTRY

Selective autophagy: Lysophagy

(2015) Junya Hasegawa et al.   METHODS

Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly

(2015) Xiaoyan Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Better Safe than Sorry: Interlinked Feedback Loops for Robust Mitophagy

(2015) Andrew G. Manford et al.   MOLECULAR CELL

USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder

(2015) Yi-Heng Hao et al.   MOLECULAR CELL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

(2015) Alban Ordureau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8

(2015) Gina A. Smith et al.   TRAFFIC

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

(2015) Fabian Hosp et al.   Cell Reports

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila

(2015) Anne-Claire Jacomin et al.   PLoS One

Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product

(2014) Rashmi K. Shrestha et al.   BIOCHEMISTRY

Regulation of Clathrin-Mediated Endocytosis by Dynamic Ubiquitination and Deubiquitination

(2014) Jasper S. Weinberg et al.   CURRENT BIOLOGY

Ubiquitin code assembly and disassembly

(2014) Claire Heride et al.   CURRENT BIOLOGY

Ubpy controls the stability of the ESCRT-0 subunit Hrs in development

(2014) J. Zhang et al.   DEVELOPMENT

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions

(2014) Teresa M. Ribeiro-Rodrigues et al.   FASEB JOURNAL

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

Interaction of SQSTM1 with the motor protein dynein - SQSTM1 is required for normal dynein function and trafficking

(2014) L. Calderilla-Barbosa et al.   JOURNAL OF CELL SCIENCE

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

(2014) Wei-Chien Yuan et al.   MOLECULAR CELL

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

USP8 Controls the Trafficking and Sorting of Lysosomal Enzymes

(2014) Ewan MacDonald et al.   TRAFFIC

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

(2014) Mohamed Elgendy et al.   Nature Communications

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

(2013) Tycho E.T. Mevissen et al.   CELL

Regulation of WASH-Dependent Actin Polymerization and Protein Trafficking by Ubiquitination

(2013) Yi-Heng Hao et al.   CELL

Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER

(2013) Zai-Rong Zhang et al.   CELL

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+Channel

(2013) Ruifeng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation regulates VCIP135 function in Golgi membrane fusion during the cell cycle

(2013) X. Zhang et al.   JOURNAL OF CELL SCIENCE

Minireview: Ubiquitination-regulated G Protein-Coupled Receptor Signaling and Trafficking

(2013) Verónica Alonso et al.   MOLECULAR ENDOCRINOLOGY

Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly–capillary malformation syndrome

(2013) Laura M McDonell et al.   NATURE GENETICS

Profiling of Parkin-Binding Partners Using Tandem Affinity Purification

(2013) Alessandra Zanon et al.   PLoS One

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

(2013) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Roles of p97-Associated Deubiquitinases in Protein Quality Control at the Endoplasmic Reticulum

(2012) Yanfen Liu et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation

(2012) Michael J. Clague et al.   DEVELOPMENTAL CELL

Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions

(2012) Sylvie Urbé et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation

(2012) Z Liu et al.   ONCOGENE

Selective protein degradation in cell signalling

(2012) Han Liu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

(2011) Alex C. Faesen et al.   CHEMISTRY & BIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

(2011) L. Zhang et al.   GENES & DEVELOPMENT

The Deubiquitinating Enzyme USP-46 Negatively Regulates the Degradation of Glutamate Receptors to Control Their Abundance in the Ventral Nerve Cord of Caenorhabditis elegans

(2011) J. R. Kowalski et al.   JOURNAL OF NEUROSCIENCE

Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

(2011) F Pareja et al.   ONCOGENE

Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus

(2011) Christopher Thorne et al.   TRAFFIC

The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle

(2011) Danming Tang et al.   Nature Communications

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells

(2010) Jennifer M. Bomberger et al.   Channels

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex

(2010) Ilana Berlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin code of yeast permease trafficking

(2010) Elsa Lauwers et al.   TRENDS IN CELL BIOLOGY

A Global Census of Fission Yeast Deubiquitinating Enzyme Localization and Interaction Networks Reveals Distinct Compartmentalization Profiles and Overlapping Functions in Endocytosis and Polarity

(2010) Ilektra Kouranti et al.   PLOS BIOLOGY

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization

(2009) Magali Berthouze et al.   EMBO JOURNAL

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

(2009) Gerco C Hassink et al.   EMBO REPORTS

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER

(2009) Robert Ernst et al.   MOLECULAR CELL

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes

(2009) Vincent Popoff et al.   TRAFFIC

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Regulation of Mitochondrial Morphology by USP30, a Deubiquitinating Enzyme Present in the Mitochondrial Outer Membrane

(2008) Nobuhiro Nakamura et al.   MOLECULAR BIOLOGY OF THE CELL

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY