Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Longitudinal Modeling of Lung Function Trajectories in Smokers with and without COPD

(2018) James C Ross et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci

(2018) Jarrett D. Morrow et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease

(2018) Moumita Ghosh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations

(2018) Maxime Lamontagne et al.   HUMAN MOLECULAR GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

(2018) Alvaro N. Barbeira et al.   Nature Communications

Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life

(2018) Dinh S Bui et al.   Lancet Respiratory Medicine

A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility

(2018) Darren A. Cusanovich et al.   CELL

Whole exome sequencing analysis in severe chronic obstructive pulmonary disease

(2018) Dandi Qiao et al.   HUMAN MOLECULAR GENETICS

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

(2017) Brian D Hobbs et al.   NATURE GENETICS

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

(2017) Louise V Wain et al.   NATURE GENETICS

The Drug Repurposing Hub: a next-generation drug library and information resource

(2017) Steven M Corsello et al.   NATURE MEDICINE

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease

(2017) Qiongshi Lu et al.   PLoS Genetics

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Joan B Soriano et al.   Lancet Respiratory Medicine

Colocalization of GWAS and eQTL Signals Detects Target Genes

(2016) Farhad Hormozdiari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Chronic Obstructive Pulmonary Disease Susceptibility Gene,FAM13A, Regulates Protein Stability of β-Catenin

(2016) Zhiqiang Jiang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exome Array Analysis Identifies a Common Variant inIL27Associated with Chronic Obstructive Pulmonary Disease

(2016) Brian D. Hobbs et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis

(2016) Olivier Boucherat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Remodeling in Pulmonary Fibrosis and Emphysema

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia

(2016) Tasha E. Fingerlin et al.   BMC GENETICS

The integrin–collagen connection – a glue for tissue repair?

(2016) Cédric Zeltz et al.   JOURNAL OF CELL SCIENCE

Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs

(2016) Kazuaki Okawa et al.   MOLECULAR BIOLOGY AND EVOLUTION

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma

(2016) Michael J. McGeachie et al.   NEW ENGLAND JOURNAL OF MEDICINE

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

Increased Epicardial Adipose Tissue Is Associated with the Airway Dominant Phenotype of Chronic Obstructive Pulmonary Disease

(2016) Yuichi Higami et al.   PLoS One

Hhiphaploinsufficiency sensitizes mice to age-related emphysema

(2016) Taotao Lao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome

(2016) Anthony D. Schmitt et al.   Cell Reports

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes

(2015) Michael H. Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants: Fig. 1.

(2015) Mitchell J. Machiela et al.   BIOINFORMATICS

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic

(2015) T Lencz et al.   MOLECULAR PSYCHIATRY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Airway Basal Cells. The “Smoking Gun” of Chronic Obstructive Pulmonary Disease

(2014) Ronald G. Crystal   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci

(2014) Kamil Slowikowski et al.   BIOINFORMATICS

Telomerase mutations in smokers with severe emphysema

(2014) Susan E. Stanley et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association analysis identifies six new loci associated with forced vital capacity

(2014) Daan W Loth et al.   NATURE GENETICS

Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema

(2014) Peter J Castaldi et al.   THORAX

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus

(2014) Craig P Hersh et al.   BMC Pulmonary Medicine

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

Heritability of Chronic Obstructive Pulmonary Disease and Related Phenotypes in Smokers

(2013) Jin J. Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Telomere length in circulating leukocytes is associated with lung function and disease

(2013) E. Albrecht et al.   EUROPEAN RESPIRATORY JOURNAL

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

The Rapid FEV1Decline in Chronic Obstructive Pulmonary Disease Is Associated with Predominant Emphysema: A Longitudinal Study

(2012) Isa Cerveri et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

The pathogenesis of COPD and IPF: Distinct horns of the same devil?

(2012) Marco Chilosi et al.   RESPIRATORY RESEARCH

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia

(2012) Mark Mellett et al.   Nature Communications

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Genetic association between human chitinases and lung function in COPD

(2011) F. Aminuddin et al.   HUMAN GENETICS

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP

(2011) Xiaobo Zhou et al.   HUMAN MOLECULAR GENETICS

ADAMTS10 Protein Interacts with Fibrillin-1 and Promotes Its Deposition in Extracellular Matrix of Cultured Fibroblasts

(2011) Wendy E. Kutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1β Induces Increased Transcriptional Activation of the Transforming Growth Factor-β-activating Integrin Subunit β8 through Altering Chromatin Architecture

(2011) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Telomerase and idiopathic pulmonary fibrosis

(2011) Mary Armanios   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

(2011) María Soler Artigas et al.   NATURE GENETICS

Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities

(2011) George R. Washko et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effects of an insertion in the 5′UTR of the AMCase on gene expression and pulmonary functions

(2011) Esra Birben et al.   RESPIRATORY MEDICINE

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Genetic Epidemiology of COPD (COPDGene) Study Design

(2010) Elizabeth A. Regan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma

(2010) Andrea Heinzmann et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases

(2009) Carole Ober et al.   Current Opinion in Allergy and Clinical Immunology

Systemic manifestations and comorbidities of COPD

(2009) P. J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

ADAMTSL-6 Is a Novel Extracellular Matrix Protein That Binds to Fibrillin-1 and Promotes Fibrillin-1 Fibril Formation

(2009) Ko Tsutsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length Regulation

(2009) Ma Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms

(2009) Suneel S. Apte   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study identifies five loci associated with lung function

(2009) Emmanouela Repapi et al.   NATURE GENETICS

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

(2009) Dana B Hancock et al.   NATURE GENETICS

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study

(2009) Jemma B. Wilk et al.   PLoS Genetics

COPD as a Systemic Disease

(2008) Àlvar Agusti et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels

(2008) Rajshekhar Chatterjee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse

(2008) Ricardo J. Giordano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY