Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Molecular Mechanisms of Cardiovascular Toxicity of Targeted Cancer Therapeutics

(2010) Hui Cheng et al.   CIRCULATION RESEARCH

Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression

(2009) Masakatsu Fukuda et al.   BMC CANCER

Data-Driven Methods to Discover Molecular Determinants of Serious Adverse Drug Events

(2009) AP Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study

(2009) Evanthia Galanis et al.   JOURNAL OF CLINICAL ONCOLOGY

Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells

(2009) Kyoji Morita et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Disease signatures are robust across tissues and experiments

(2009) Joel T Dudley et al.   Molecular Systems Biology

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

Integrative genomics and drug development

(2009) Pek Y Lum et al.   PHARMACOGENOMICS

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

(2009) Sarah L. Kinnings et al.   PLoS Computational Biology

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

(2009) Li Xie et al.   PLoS Computational Biology

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease

(2009) Radu Dobrin et al.   GENOME BIOLOGY

Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro

(2008) Hedwig E. Deubzer et al.   CANCER LETTERS

Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site

(2008) Jing Gao et al.   GLIA

ERCC5Is a Novel Biomarker of Ovarian Cancer Prognosis

(2008) Christine S. Walsh et al.   JOURNAL OF CLINICAL ONCOLOGY

Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate Cancer

(2008) Sunita R. Setlur et al.   JNCI-Journal of the National Cancer Institute

Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis

(2008) W.Z. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One

A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities

(2008) K. S. Garman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE