Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions

Partial loss of complex I due to NDUFS4 deficiency augments myocardial reperfusion damage by increasing mitochondrial superoxide/hydrogen peroxide production

(2018) Nidhi Kuksal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol–mediated cardioprotection against hypoxia/reoxygenation–induced oxidative stress

(2018) Yi Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide

(2018) Hani N. Sabbah et al.   CARDIOVASCULAR DRUGS AND THERAPY

Melatonin therapy for diabetic cardiomyopathy: A mechanism involving Syk-mitochondrial complex I-SERCA pathway

(2018) Hao Zhou et al.   CELLULAR SIGNALLING

Raising NAD in Heart Failure

(2018) Matthew A. Walker et al.   CIRCULATION

Human diseases associated with defects in assembly of OXPHOS complexes

(2018) Daniele Ghezzi et al.   Essays in Biochemistry

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Iron deficiency without anemia is responsible for decreased left ventricular function and reduced mitochondrial complex I activity in a mouse model

(2018) Emmanuel Rineau et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

(2018) Rachel A. Gioscia-Ryan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

(2018) Georges N. Kanaan et al.   Redox Biology

Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria

(2018) Julia Chalker et al.   Redox Biology

Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury

(2018) Huiliang Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial dynamics: Biological roles, molecular machinery, and related diseases

(2018) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Adenosine A 2 receptor activation ameliorates mitochondrial oxidative stress upon reperfusion through the posttranslational modification of NDUFV2 subunit of complex I in the heart

(2017) Jingman Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit

(2017) Salvatore Raffa et al.   HUMAN MOLECULAR GENETICS

Assembly defects of multiple respiratory chain complexes in a child with cardiac hypertrophy associated with a novel ACAD9 mutation

(2017) Konstantina Fragaki et al.   MOLECULAR GENETICS AND METABOLISM

Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3

(2017) Hengxun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

(2017) Liming Yu et al.   Scientific Reports

Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice

(2016) Hung-i Lu et al.   ACTA PHARMACOLOGICA SINICA

Complex I function in mitochondrial supercomplexes

(2016) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial complex I

(2016) Christophe Wirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling

(2016) Yanping Miao et al.   BRAIN RESEARCH BULLETIN

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure

(2016) Rob C.I. Wüst et al.   CARDIOVASCULAR RESEARCH

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Mitochondrial Biology and Neurological Diseases

(2016) Siddharth Arun et al.   Current Neuropharmacology

Mitochondrial dynamics and cell death in heart failure

(2016) José Marín-García et al.   HEART FAILURE REVIEWS

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Disrupted mitochondrial genes and inflammation following stroke

(2016) Whitney S. Gibbs et al.   LIFE SCIENCES

Ndufs4 related Leigh syndrome: A case report and review of the literature

(2016) Juan Darío Ortigoza-Escobar et al.   MITOCHONDRION

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

Epidemiology and aetiology of heart failure

(2016) Boback Ziaeian et al.   Nature Reviews Cardiology

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease

(2016) Speranza Rubattu et al.   Oxidative Medicine and Cellular Longevity

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

(2016) Alfonso Eirin et al.   Journal of the American Heart Association

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease

(2016) Speranza Rubattu et al.   Journal of the American Heart Association

Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart

(2015) Edwin J. Vazquez et al.   CARDIOVASCULAR RESEARCH

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

A mitochondria-targeted derivative of ascorbate: MitoC

(2015) Peter G. Finichiu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetic Cardiovascular Disease Induced by Oxidative Stress

(2015) Yosuke Kayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A giant molecular proton pump: structure and mechanism of respiratory complex I

(2015) Leonid A. Sazanov   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

(2015) Victoria J.A. Jameson et al.   TETRAHEDRON

NAMPT as a Therapeutic Target against Stroke

(2015) Pei Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Extracellular Visfatin has Nicotinamide Phosphoribosyltransferase Enzymatic Activity and is Neuroprotective Against Ischemic Injury

(2014) Yan Zhao et al.   CNS Neuroscience & Therapeutics

Targeting CD36-Mediated Inflammation Reduces Acute Brain Injury in Transient, but not Permanent, Ischemic Stroke

(2014) Eun-Hee Kim et al.   CNS Neuroscience & Therapeutics

Disrupting Mitochondrial–Nuclear Coevolution Affects OXPHOS Complex I Integrity and Impacts Human Health

(2014) Moran Gershoni et al.   Genome Biology and Evolution

Cell-permeable protein therapy for complex I dysfunction

(2014) Salvatore Pepe et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions

(2014) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency

(2014) Immo E. Scheffler   JOURNAL OF INHERITED METABOLIC DISEASE

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Complex I Deficiency Due to Selective Loss of Ndufs4 in the Mouse Heart Results in Severe Hypertrophic Cardiomyopathy

(2014) Edward T. Chouchani et al.   PLoS One

Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis

(2013) Randa Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways

(2013) Yong-guang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart

(2013) Jasenka Kraljevic et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

Mitochondrial encoded NADH dehydrogenase 5 (MT-ND5) gene point mutation presents as late onset cardiomyopathy

(2013) Nir Ayalon et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The breathing heart — Mitochondrial respiratory chain dysfunction in cardiac disease

(2013) Konstantin Schwarz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Reduction of Infarct Size by the Therapeutic Protein TAT-Ndi1 In Vivo

(2013) Robert M. Mentzer et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

(2013) Ryan J. Mailloux et al.   Redox Biology

Mitochondria in vascular disease

(2012) E. Yu et al.   CARDIOVASCULAR RESEARCH

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

(2012) M. D. Nitert et al.   DIABETES

Mouse models of mitochondrial complex I dysfunction

(2012) Michael H. Irwin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial DNA Variant for Complex I Reveals a Role in Diabetic Cardiac Remodeling

(2012) Savitha Sethumadhavan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex I deficiency: clinical features, biochemistry and molecular genetics

(2012) Elisa Fassone et al.   JOURNAL OF MEDICAL GENETICS

Mitochondria as a Therapeutic Target in Heart Failure

(2012) Marina Bayeva et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy

(2012) B.-X. Ke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of mitochondrial processes by protein S-nitrosylation

(2011) Claude A. Piantadosi   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain

(2011) Ken Shinmura et al.   CIRCULATION RESEARCH

Tissue Doppler and Strain Rate Imaging Detect Improvement of Myocardial Function in Iron Deficient Patients with Congestive Heart Failure after Iron Replacement Therapy

(2011) Rania Gaber et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo

(2011) Anders H Olsson et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Caloric Restriction Ameliorates Angiotensin II–Induced Mitochondrial Remodeling and Cardiac Hypertrophy

(2011) Piet Finckenberg et al.   HYPERTENSION

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

(2011) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visfatin and Cardio–Cerebro–Vascular Disease

(2011) Pei Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mutations in the mitochondrial complex I assembly factor NDUFAF1 cause fatal infantile hypertrophic cardiomyopathy

(2011) E. Fassone et al.   JOURNAL OF MEDICAL GENETICS

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

The Athlete's Heart vs. the Failing Heart: Can Signaling Explain the Two Distinct Outcomes?

(2011) Kate L. Weeks et al.   PHYSIOLOGY

Xenotransplantation of Mitochondrial Electron Transfer Enzyme, Ndi1, in Myocardial Reperfusion Injury

(2011) Cynthia N. Perry et al.   PLoS One

The Cardiac Mitochondrion: Nexus of Stress

(2010) Christopher P. Baines   Annual Review of Physiology

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease

(2010) Shankar J. Chinta et al.   FREE RADICAL RESEARCH

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)

(2009) L. E. Bakeeva et al.   BIOCHEMISTRY-MOSCOW

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress

(2009) Eric R. Griffiths et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

NDUFS4: Creation of a mouse model mimicking a Complex I disorder

(2009) Christopher A. Ingraham et al.   MITOCHONDRION

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

(2009) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit

(2008) Thomas R. Hurd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose

(2008) Yong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA