Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease

Mitochondrial health, the epigenome and healthspan

(2016) M. A. Aon et al.   CLINICAL SCIENCE

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease

(2016) Speranza Rubattu et al.   Journal of the American Heart Association

Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases

(2015) O. S. Kornfeld et al.   CIRCULATION RESEARCH

Prohibitin protects proximal tubule epithelial cells against oxidative injury through mitochondrial pathways

(2015) J. Ye et al.   FREE RADICAL RESEARCH

Downregulation of Nuclear Factor Erythroid 2–Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension

(2015) Rhéure A. Lopes et al.   HYPERTENSION

MiR-34a regulates blood–brain barrier permeability and mitochondrial function by targeting cytochrome c

(2015) Mimi Bukeirat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP

(2015) Speranza Rubattu et al.   JOURNAL OF HYPERTENSION

Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart

(2015) Jianru Shi et al.   LIFE SCIENCES

Characterization of mitochondrial NADH dehydrogenase 1α subcomplex 10 variants in cardiac muscles from normal Wistar rats and spontaneously hypertensive rats: Implications in the pathogenesis of hypertension

(2015) LIYING HUANG et al.   Molecular Medicine Reports

Understanding and Improving Cardiovascular Health: An Update on the American Heart Association's Concept of Cardiovascular Health

(2015) Christina M. Shay et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains

(2015) Speranza Rubattu et al.   Oncotarget

Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art

(2015) Beniamino Pagliaro et al.   Biomed Research International

Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney

(2015) Bianca Marmontel de Souza et al.   PLoS One

Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases

(2014) Speranza Rubattu et al.   CLINICAL SCIENCE

Mitochondrial injury and dysfunction in hypertension-induced cardiac damage

(2014) A. Eirin et al.   EUROPEAN HEART JOURNAL

Disrupting Mitochondrial–Nuclear Coevolution Affects OXPHOS Complex I Integrity and Impacts Human Health

(2014) Moran Gershoni et al.   Genome Biology and Evolution

Ablation of uncoupling protein 2 exacerbates salt-induced cardiovascular and renal remodeling associated with enhanced oxidative stress

(2014) Shuangtao Ma et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress

(2014) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke

(2014) Emma L. Bailey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Transgenic Overexpression of Uncoupling Protein 2 Attenuates Salt-Induced Vascular Dysfunction by Inhibition of Oxidative Stress

(2013) S. Ma et al.   AMERICAN JOURNAL OF HYPERTENSION

Role of mitochondrial oxidative stress in hypertension

(2013) Sergey I. Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons

(2013) Adam J. Case et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat

(2013) Ying Tang et al.   CARDIOVASCULAR PATHOLOGY

Natriuretic peptides in cardiovascular diseases: current use and perspectives

(2013) M. Volpe et al.   EUROPEAN HEART JOURNAL

Interaction Between Chromosome 2 and 3 Regulates Pulse Pressure in the Stroke-Prone Spontaneously Hypertensive Rat

(2013) H.H. Caline Koh-Tan et al.   HYPERTENSION

Two Genomic Regions of Chromosomes 1 and 18 Explain Most of the Stroke Susceptibility Under Salt Loading in Stroke-Prone Spontaneously Hypertensive Rat/Izm

(2013) Tsend-Ayush Gandolgor et al.   HYPERTENSION

Differential Modulation of Uncoupling Protein 2 in Kidneys of Stroke-Prone Spontaneously Hypertensive Rats Under High-Salt/Low-Potassium Diet

(2013) Sara Di Castro et al.   HYPERTENSION

Differential regulation of atrial contraction by P1 and P2 purinoceptors in normotensive and spontaneously hypertensive rats

(2013) Juliano Quintella Dantas Rodrigues et al.   HYPERTENSION RESEARCH

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function

(2013) Jennifer McLachlan et al.   JOURNAL OF HYPERTENSION

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria in vascular disease

(2012) E. Yu et al.   CARDIOVASCULAR RESEARCH

Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice

(2012) Xiao Yu Tian et al.   CIRCULATION RESEARCH

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

(2012) M. D. Nitert et al.   DIABETES

Angiotensin Receptor Blockade Recovers Hepatic UCP2 Expression and Aconitase and SDH Activities and Ameliorates Hepatic Oxidative Damage in Insulin Resistant Rats

(2012) Priscilla Montez et al.   ENDOCRINOLOGY

A Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes After Revascularization in Experimental Atherosclerotic Renal Artery Stenosis

(2012) Alfonso Eirin et al.   HYPERTENSION

The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?

(2012) Toru Nabika et al.   HYPERTENSION RESEARCH

Understanding mitochondrial complex I assembly in health and disease

(2011) Masakazu Mimaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo

(2011) Anders H Olsson et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Kidney Pathology Precedes and Predicts the Pathological Cascade of Cerebrovascular Lesions in Stroke Prone Rats

(2011) Stefanie Schreiber et al.   PLoS One

Uncoupling Protein 2 Ablation Exacerbates High-Salt Intake-Induced Vascular Dysfunction

(2010) S. Ma et al.   AMERICAN JOURNAL OF HYPERTENSION

Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency

(2010) Saskia Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Increased expression of pro-inflammatory genes in abdominal subcutaneous fat in advanced chronic kidney disease patients

(2010) A. Witasp et al.   JOURNAL OF INTERNAL MEDICINE

Peroxisome Proliferator-Activated Receptor   Agonism Prevents Renal Damage and the Oxidative Stress and Inflammatory Processes Affecting the Brains of Stroke-Prone Rats

(2010) P. Gelosa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate–activated protein kinase activation

(2010) Atsuko Tomizawa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats

(2010) Weijie Yi et al.   NUTRITION

Uncoupling protein-2 regulates lifespan in mice

(2009) Zane B. Andrews et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals

(2009) T. Yoshida et al.   Clinical Journal of the American Society of Nephrology

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

Redox Signaling, Vascular Function, and Hypertension

(2008) Moo Yeol Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic risk factors for renal failure among North Indian ESRD patients

(2008) Gaurav Tripathi et al.   CLINICAL BIOCHEMISTRY

S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function

(2008) Paolo Gelosa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Dysfunction in the Hypertensive Rat Brain

(2008) Ana Lopez-Campistrous et al.   HYPERTENSION

Do in vivo Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review

(2008) Atticus H Hainsworth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice

(2008) Fatiha Moukdar et al.   JOURNAL OF LIPID RESEARCH

Excess Salt Causes Cerebral Neuronal Apoptosis and Inflammation in Stroke-Prone Hypertensive Rats Through Angiotensin II-Induced NADPH Oxidase Activation

(2008) Eiichiro Yamamoto et al.   STROKE

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH