Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

Structural insights into the activation of metabotropic glutamate receptors

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Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning

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Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs

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Molecular insights into allosteric modulation of Class C G protein-coupled receptors

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The anatomy of mammalian sweet taste receptors

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Structural basis for perception of diverse chemical substances by T1r taste receptors

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope

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Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

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Taste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domains

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Intracellular acidification is required for full activation of the sweet taste receptor by miraculin

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Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications

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Structural mechanism of ligand activation in human calcium-sensing receptor

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Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist

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Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor

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N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization

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Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)

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Conserved function of the lysine-based KXD/E motif in Golgi retention for endomembrane proteins among different organisms

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Conformational dynamics of a class C G-protein-coupled receptor

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Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor

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Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids

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Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

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Distinct Human and Mouse Membrane Trafficking Systems for Sweet Taste Receptors T1r2 and T1r3

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Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

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Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy

(2014) Linnea Olofsson et al.   Nature Communications

Why is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis

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ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function

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Computational Design of a Protein-Based Enzyme Inhibitor

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Structural mechanism of ligand activation in human GABAB receptor

(2013) Yong Geng et al.   NATURE

A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells

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Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors

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Structure and ligand recognition of class C GPCRs

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Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

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Enrich: software for analysis of protein function by enrichment and depletion of variants

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Crystal structure of the β2 adrenergic receptor–Gs protein complex

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RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

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Interdomain movements in metabotropic glutamate receptor activation

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GFP-based evaluation system of recombinant expression through the secretory pathway in insect cells and its application to the extracellular domains of class C GPCRs

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Deep mutational scanning: assessing protein function on a massive scale

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ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

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Solution of the Structure of the TNF-TNFR2 Complex

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