Mapping Interaction Sites on Human Chemokine Receptors by Deep Mutational Scanning

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

(2017) Gabriel Ozorowski et al.   NATURE

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Structural basis of ligand interaction with atypical chemokine receptor 3

(2017) Martin Gustavsson et al.   Nature Communications

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration

(2016) Mark A. Hauser et al.   IMMUNITY

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

(2016) Melanie P. Wescott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

(2016) Daniel T. Harris et al.   STRUCTURE

Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5

(2016) Kayan Tam et al.   mBio

Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts

(2016) Marco Schütz et al.   Scientific Reports

Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4

(2016) Kristyna Pluhackova et al.   PLoS Computational Biology

Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV’s Envelope Protein on Viral Replication in Cell Culture

(2016) Hugh K. Haddox et al.   PLoS Pathogens

Association of eukaryotic translation initiation factor eIF2B with fully solubilized CXCR4

(2015) E. Palmesino et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Antibody Epitopes on G Protein-Coupled Receptors Mapped with Genetically Encoded Photoactivatable Cross-Linkers

(2014) Sarmistha Ray-Saha et al.   BIOCHEMISTRY

CCR5 Conformations Are Dynamic and Modulated by Localization, Trafficking and G Protein Association

(2014) Ayanna J. Flegler et al.   PLoS One

Molecular Recognition of CCR5 by an HIV-1 gp120 V3 Loop

(2014) Phanourios Tamamis et al.   PLoS One

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

(2014) Irina Kufareva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface

(2014) L. Martinez-Munoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rapid screening and production method using a novel mammalian cell display to isolate human monoclonal antibodies

(2013) Kosuke Tomimatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV-1 envelope glycoprotein structure

(2013) Alan Merk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Computational Design of a Protein-Based Enzyme Inhibitor

(2013) Erik Procko et al.   JOURNAL OF MOLECULAR BIOLOGY

Deep mutational scanning of an antibody against epidermal growth factor receptor using mammalian cell display and massively parallel pyrosequencing

(2013) Charles M. Forsyth et al.   mAbs

Mammalian cell display for the discovery and optimization of antibody therapeutics

(2013) Peter M. Bowers et al.   METHODS

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

(2013) Michael Roche et al.   Retrovirology

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

The spatial architecture of protein function and adaptation

(2012) Richard N. McLaughlin Jr et al.   NATURE

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

(2012) Timothy A Whitehead et al.   NATURE BIOTECHNOLOGY

Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations

(2012) K. M. Schlinkmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enrich: software for analysis of protein function by enrichment and depletion of variants

(2011) Douglas M. Fowler et al.   BIOINFORMATICS

Allosteric Model of Maraviroc Binding to CC Chemokine Receptor 5 (CCR5)

(2011) Javier Garcia-Perez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Three Human GPCRs for Higher Expression and Stability

(2011) Igor Dodevski et al.   JOURNAL OF MOLECULAR BIOLOGY

The Conformation and Orientation of a 27-Residue CCR5 Peptide in a Ternary Complex with HIV-1 gp120 and a CD4-Mimic Peptide

(2011) Einat Schnur et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors

(2011) R. Berro et al.   JOURNAL OF VIROLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

(2011) P. M. Bowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An improved bimolecular fluorescence complementation assay with a high signal-to-noise ratio

(2010) Yutaka Kodama* et al.   BIOTECHNIQUES

High-resolution mapping of protein sequence-function relationships

(2010) Douglas M Fowler et al.   NATURE METHODS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

(2009) Denis Sohy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atomic-Level Mapping of Antibody Epitopes on a GPCR

(2009) Cheryl Paes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

(2008) C. A. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE