Structure and ligand recognition of class C GPCRs

Glutamate Receptors as Therapeutic Targets for Parkinsons Disease

(2012) Kari Johnson et al.   CNS & Neurological Disorders-Drug Targets

Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: Results of a randomized, double-blinded, placebo-controlled Phase II clinical trial

(2011) Lorraine A. Fitzpatrick et al.   BONE

Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives

(2011) S. Urwyler   PHARMACOLOGICAL REVIEWS

Dimers and beyond: The functional puzzles of class C GPCRs

(2011) Julie Kniazeff et al.   PHARMACOLOGY & THERAPEUTICS

Interdomain movements in metabotropic glutamate receptor activation

(2011) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Trans-activation between 7TM domains: implication in heterodimeric GABABreceptor activation

(2010) Carine Monnier et al.   EMBO JOURNAL

Ligand-induced Rearrangements of the GABABReceptor Revealed by Fluorescence Resonance Energy Transfer

(2010) Shinichi Matsushita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists

(2010) Chelliah Selvam et al.   JOURNAL OF MEDICINAL CHEMISTRY

GABAB Receptor Activation Protects Neurons from Apoptosis via IGF-1 Receptor Transactivation

(2010) H. Tu et al.   JOURNAL OF NEUROSCIENCE

The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

(2010) Philippe Rondard et al.   NEUROPHARMACOLOGY

Allosteric modulation of metabotropic glutamate receptors: Structural insights and therapeutic potential

(2010) Karen J. Gregory et al.   NEUROPHARMACOLOGY

Mechanism-based approaches to treating fragile X

(2010) Gül Dölen et al.   PHARMACOLOGY & THERAPEUTICS

Molecular mechanism of the sweet taste enhancers

(2010) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence

(2009) Jianhua Cao et al.   BMC EVOLUTIONARY BIOLOGY

Future therapeutic targets in osteoporosis

(2009) Chad Deal   CURRENT OPINION IN RHEUMATOLOGY

Anti-Parathyroid and Anti-Calcium Sensing Receptor Antibodies in Autoimmune Hypoparathyroidism

(2009) Edward M. Brown   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Agonists and Allosteric Modulators of the Calcium-Sensing Receptor and Their Therapeutic Applications

(2009) Z. Saidak et al.   MOLECULAR PHARMACOLOGY

Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization

(2009) P. Marcaggi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic receptors for glutamate and GABA in pain

(2008) Cyril Goudet et al.   BRAIN RESEARCH REVIEWS

Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors

(2008) P Malherbe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functioning of the dimeric GABAB receptor extracellular domain revealed by glycan wedge scanning

(2008) Philippe Rondard et al.   EMBO JOURNAL

Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site

(2008) B. A. Rowe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanism for the umami taste synergism

(2008) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

(2008) P. Jeffrey Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES