The Immunosuppressive Effect of CTLA4 Immunoglobulin Is Dependent on Regulatory T Cells at Low But Not High Doses

CD28/CTLA-4/B7 costimulatory pathway blockade affects regulatory T-cell function in autoimmunity

(2015) Isabel Vogel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Does belatacept improve outcomes for kidney transplant recipients? A systematic review

(2015) Nishanthi Talawila et al.   TRANSPLANT INTERNATIONAL

Donor CD4 T Cells Trigger Costimulation Blockade-Resistant Donor Bone Marrow Rejection Through Bystander Activation Requiring IL-6

(2014) K. Hock et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Understanding the CD28/CTLA-4 (CD152) Pathway and Its Implications for Costimulatory Blockade

(2014) D. Gardner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Belatacept-Based Immunosuppression inDe NovoLiver Transplant Recipients: 1-Year Experience From a Phase II Randomized Study

(2014) G. B. Klintmalm et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Belatacept treatment for two yr after liver transplantation is not associated with operational tolerance

(2014) Christoph Schwarz et al.   CLINICAL TRANSPLANTATION

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Homeostasis and function of regulatory T cells (Tregs)in vivo: lessons from TCR-transgenic Tregs

(2014) Kesley Attridge et al.   IMMUNOLOGICAL REVIEWS

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3+ and Foxp3− T cells

(2014) Dean Franckaert et al.   IMMUNOLOGY AND CELL BIOLOGY

Harnessing FOXP3+ regulatory T cells for transplantation tolerance

(2014) Herman Waldmann et al.   JOURNAL OF CLINICAL INVESTIGATION

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells

(2014) F. Guo et al.   JOURNAL OF IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

(2014) Yuka Maeda et al.   SCIENCE

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

Depletion of T Regulatory Cells Promotes Natural Killer Cell–Mediated Cardiac Allograft Vasculopathy

(2014) Tsutomu Hirohashi et al.   TRANSPLANTATION

CTLA4-Ig Preserves Thymus-Derived T Regulatory Cells

(2014) Sarah M. Ahmadi et al.   TRANSPLANTATION

An Anti-CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+iTreg in the Absence and Presence of CTLA-4 Ig

(2013) D. F. Pinelli et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CTLA4Ig Inhibits Effector T Cells through Regulatory T Cells and TGF- 

(2013) C. M. Deppong et al.   JOURNAL OF IMMUNOLOGY

Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model

(2013) Douglas C. Wu et al.   TRANSPLANTATION

Inhibitory Effects of Belatacept on Allospecific Regulatory T-Cell Generation in Humans

(2013) Josh Levitsky et al.   TRANSPLANTATION

CTLA4-Ig Restores Rejection of MHC Class-II Mismatched Allografts by Disabling IL-2-Expanded Regulatory T Cells

(2012) L.-M. Charbonnier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model

(2012) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cutting Edge: Cell-Extrinsic Immune Regulation by CTLA-4 Expressed on Conventional T Cells

(2012) C. J. Wang et al.   JOURNAL OF IMMUNOLOGY

Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients

(2012) Haley Ramsey et al.   TRANSPLANT INTERNATIONAL

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

(2011) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CTLA-4-Ig Therapy Diminishes the Frequency but Enhances the Function of Treg Cells in Patients with Rheumatoid Arthritis

(2011) Crisol Álvarez-Quiroga et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IDO and Regulatory T Cell Support Are Critical for Cytotoxic T Lymphocyte-Associated Ag-4 Ig-Mediated Long-Term Solid Organ Allograft Survival

(2011) R. Sucher et al.   JOURNAL OF IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Belatacept: from rational design to clinical application

(2011) Thomas Wekerle et al.   TRANSPLANT INTERNATIONAL

Therapeutic Efficacy of Polyclonal Tregs Does Not Require Rapamycin in a Low-Dose Irradiation Bone Marrow Transplantation Model

(2011) Nina Pilat et al.   TRANSPLANTATION

A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT-EXT Study)

(2010) A. Durrbach et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

(2010) N. Poirier et al.   Science Translational Medicine

PD-1/B7-H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft

(2009) M. Morita et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

(2008) J. A. Bluestone et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CTLA-4{middle dot}Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells

(2008) M. Razmara et al.   INTERNATIONAL IMMUNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE