Homeostasis and function of regulatory T cells (Tregs)in vivo: lessons from TCR-transgenic Tregs
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Title
Homeostasis and function of regulatory T cells (Tregs)in vivo: lessons from TCR-transgenic Tregs
Authors
Keywords
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Journal
IMMUNOLOGICAL REVIEWS
Volume 259, Issue 1, Pages 23-39
Publisher
Wiley
Online
2014-04-09
DOI
10.1111/imr.12165
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Note: Only part of the references are listed.- Cutting Edge: Autoimmune Disease in Day 3 Thymectomized Mice Is Actively Controlled by Endogenous Disease-Specific Regulatory T Cells
- (2014) E. T. Samy et al. JOURNAL OF IMMUNOLOGY
- CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis
- (2014) A. L. Tang et al. JOURNAL OF IMMUNOLOGY
- CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function
- (2014) T. N. Golovina et al. JOURNAL OF IMMUNOLOGY
- CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity
- (2014) E. M. Schmidt et al. JOURNAL OF IMMUNOLOGY
- Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21
- (2014) L. E. Clough et al. JOURNAL OF IMMUNOLOGY
- The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells
- (2014) A. Schneider et al. JOURNAL OF IMMUNOLOGY
- Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells
- (2013) J. H. Peters et al. BLOOD
- ICOS controls Foxp3+regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
- (2013) Stephen A. Redpath et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals
- (2013) Xuguang Tai et al. IMMUNITY
- Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults
- (2013) Laura F. Su et al. IMMUNITY
- Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12
- (2013) Shahin Shafiani et al. IMMUNITY
- Role of regulatory T cells during virus infection
- (2013) Tamara Veiga-Parga et al. IMMUNOLOGICAL REVIEWS
- Treg and CTLA-4: Two intertwining pathways to immune tolerance
- (2013) Lucy S.K. Walker JOURNAL OF AUTOIMMUNITY
- Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
- (2013) Jonathan Sitrin et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development
- (2013) G. Cheng et al. JOURNAL OF IMMUNOLOGY
- Comparison of Induced versus Natural Regulatory T Cells of the Same TCR Specificity for Induction of Tolerance to an Environmental Antigen
- (2013) H. Huang et al. JOURNAL OF IMMUNOLOGY
- Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
- (2013) Greg M. Delgoffe et al. NATURE
- mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
- (2013) Hu Zeng et al. NATURE
- Regulatory T cells in nonlymphoid tissues
- (2013) Dalia Burzyn et al. NATURE IMMUNOLOGY
- Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells
- (2013) Wim Pierson et al. NATURE IMMUNOLOGY
- Regulatory T cells: recommendations to simplify the nomenclature
- (2013) Abul K Abbas et al. NATURE IMMUNOLOGY
- Cell-Intrinsic Role for NF-kappa B-Inducing Kinase in Peripheral Maintenance but Not Thymic Development of Foxp3+ Regulatory T Cells in Mice
- (2013) Susan E. Murray PLoS One
- Excessive Th1 responses due to the absence of TGF- signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis
- (2013) H. Ishigame et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease
- (2013) K.-i. Matsuoka et al. Science Translational Medicine
- TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function
- (2013) Anna Śledzińska et al. PLOS BIOLOGY
- IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
- (2013) Iwana Schmitz et al. PLoS Pathogens
- Foxp3+Helios+regulatory T cells are expanded in active systemic lupus erythematosus
- (2012) Tobias Alexander et al. ANNALS OF THE RHEUMATIC DISEASES
- IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis
- (2012) K. Attridge et al. BLOOD
- The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences
- (2012) A. Sainz-Perez et al. CANCER RESEARCH
- VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer
- (2012) M. Terme et al. CANCER RESEARCH
- Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by inducedCD28deletion
- (2012) Tea Gogishvili et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets
- (2012) Taheri Sathaliyawala et al. IMMUNITY
- Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells
- (2012) Jonathan M. Weiss et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
- (2012) Mahesh Yadav et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo
- (2012) T. Zou et al. JOURNAL OF IMMUNOLOGY
- Requirement for Diverse TCR Specificities Determines Regulatory T Cell Activity in a Mouse Model of Autoimmune Arthritis
- (2012) S. Oh et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Cell-Extrinsic Immune Regulation by CTLA-4 Expressed on Conventional T Cells
- (2012) C. J. Wang et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans
- (2012) E. Corse et al. JOURNAL OF IMMUNOLOGY
- The Thymic Niche Does Not Limit Development of the Naturally Diverse Population of Mouse Regulatory T Lymphocytes
- (2012) P. Romagnoli et al. JOURNAL OF IMMUNOLOGY
- High TCR diversity ensures optimal function andhomeostasis of Foxp3+regulatory Tcells
- (2011) Lisa Föhse et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function
- (2011) Jessica Herrath et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family
- (2011) Hélène Bour-Jordan et al. IMMUNOLOGICAL REVIEWS
- Cutting Edge: De Novo Induction of Functional Foxp3+ Regulatory CD4 T Cells in Response to Tissue-Restricted Self Antigen
- (2011) L. J. Thompson et al. JOURNAL OF IMMUNOLOGY
- Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells
- (2011) R. A. Gottschalk et al. JOURNAL OF IMMUNOLOGY
- A Role for IL-27 in Limiting T Regulatory Cell Populations
- (2011) E. D. Tait Wojno et al. JOURNAL OF IMMUNOLOGY
- A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease
- (2011) J. R. Killebrew et al. JOURNAL OF IMMUNOLOGY
- Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction
- (2011) W. Kastenmuller et al. JOURNAL OF IMMUNOLOGY
- Influenza A Virus Infection Results in a Robust, Antigen-Responsive, and Widely Disseminated Foxp3+ Regulatory T Cell Response
- (2011) R. J. Betts et al. JOURNAL OF VIROLOGY
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- (2011) Derek A. Wainwright et al. NEURO-ONCOLOGY
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- (2011) Jeffrey A. Bluestone NEW ENGLAND JOURNAL OF MEDICINE
- Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis
- (2011) David Saadoun et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
- (2011) John Koreth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Helios Expression Is a Marker of T Cell Activation and Proliferation
- (2011) Tatiana Akimova et al. PLoS One
- Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens
- (2011) George A. Punkosdy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
- (2011) O. S. Qureshi et al. SCIENCE
- Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation
- (2010) Liat Bar-On et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs
- (2010) Yenkel Grinberg-Bleyer et al. JOURNAL OF CLINICAL INVESTIGATION
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
- (2010) Rachel A. Gottschalk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints
- (2010) Junko Nishio et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis
- (2010) Shahin Shafiani et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
- (2010) Yenkel Grinberg-Bleyer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Dendritic Cells Induce Regulatory T Cell Proliferation through Antigen-Dependent and -Independent Interactions
- (2010) T. Zou et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells
- (2010) L. Barron et al. JOURNAL OF IMMUNOLOGY
- Comment on "Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells"
- (2010) J. Verhagen et al. JOURNAL OF IMMUNOLOGY
- Dendritic Cells Support Homeostatic Expansion of Foxp3 + Regulatory T Cells in Foxp3.LuciDTR Mice
- (2010) Janine Suffner et al. JOURNAL OF IMMUNOLOGY
- Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
- (2010) A. M. Thornton et al. JOURNAL OF IMMUNOLOGY
- A Major Role for Bim in Regulatory T Cell Homeostasis
- (2010) C. A. Chougnet et al. JOURNAL OF IMMUNOLOGY
- Stability of the Regulatory T Cell Lineage in Vivo
- (2010) Y. P. Rubtsov et al. SCIENCE
- Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
- (2009) D. J. Chung et al. BLOOD
- Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment
- (2009) L. K. Swee et al. BLOOD
- Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein
- (2009) Li-Fan Lu et al. IMMUNITY
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
- (2009) Makoto Miyara et al. IMMUNITY
- Regulatory T cells overturned: the effectors fight back
- (2009) Lucy S. K. Walker IMMUNOLOGY
- Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells
- (2009) Julie A. Carman et al. JOURNAL OF CLINICAL IMMUNOLOGY
- TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes
- (2009) Monica W.L. Leung et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
- (2009) Guillaume Darrasse-Jèze et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
- (2009) Caspar Ohnmacht et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells
- (2009) W. E. O'Gorman et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity
- (2009) K. M. Wheeler et al. JOURNAL OF IMMUNOLOGY
- CD4 + CD25 + Foxp3 + T Regulatory Cells with Limited TCR Diversity in Control of Autoimmunity
- (2009) Dennis Adeegbe et al. JOURNAL OF IMMUNOLOGY
- CTLA-4 suppresses the pathogenicity of self antigen–specific T cells by cell-intrinsic and cell-extrinsic mechanisms
- (2009) Wataru Ise et al. NATURE IMMUNOLOGY
- Intraclonal competition limits the fate determination of regulatory T cells in the thymus
- (2009) Jhoanne L Bautista et al. NATURE IMMUNOLOGY
- Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
- (2009) Markus Feuerer et al. NATURE MEDICINE
- Impact of the TCR Signal on Regulatory T Cell Homeostasis, Function, and Trafficking
- (2009) Joong Kyu Kim et al. PLoS One
- Infectious tolerance via the consumption of essential amino acids and mTOR signaling
- (2009) S. P. Cobbold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells
- (2009) A. Schildknecht et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The control of CD4+CD25+Foxp3+ regulatory T cell survival
- (2008) Pushpa Pandiyan et al. Biology Direct
- CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion
- (2008) B. Kavanagh et al. BLOOD
- Increased resistance to CD4+CD25hiregulatory T cell-mediated suppression in patients with type 1 diabetes
- (2008) J. M. Lawson et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Early recruitment of natural CD4+Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
- (2008) Matthew D. Taylor et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Natural Treg in autoimmune diabetes: all present and correct?
- (2008) Lucy SK Walker EXPERT OPINION ON BIOLOGICAL THERAPY
- Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction
- (2008) Qizhi Tang et al. IMMUNITY
- The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo
- (2008) Milica Vukmanovic-Stejic et al. JOURNAL OF CLINICAL INVESTIGATION
- HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism
- (2008) Olivier Manches et al. JOURNAL OF CLINICAL INVESTIGATION
- Antigen-specific peripheral shaping of the natural regulatory T cell population
- (2008) Stephanie K. Lathrop et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
- (2008) Qizhi Tang et al. NATURE IMMUNOLOGY
- Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
- (2008) Y. Onishi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
- (2008) A. M. D'Alise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CTLA-4 Control over Foxp3+ Regulatory T Cell Function
- (2008) K. Wing et al. SCIENCE
- Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction
- (2007) Patricia M. Davis et al. CLINICAL IMMUNOLOGY
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