Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets

Latest developments in MUC1 immunotherapy

(2018) Joyce Taylor-Papadimitriou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The autotaxin - lysophosphatidic acid axis promotes lung carcinogenesis

(2018) Christiana Magkrioti et al.   CANCER RESEARCH

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

(2018) Jessica Lawrence et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-fibrotic effects of pirfenidone by interference with the hedgehog signalling pathway in patients with systemic sclerosis-associated interstitial lung disease

(2018) Hua Xiao et al.   International Journal of Rheumatic Diseases

Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung

(2018) Takuya Ueda et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

MUC1-C drives myeloid leukaemogenesis and resistance to treatment by a survivin-mediated mechanism

(2018) Dina Stroopinsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

From bad to worse: when lung cancer complicates idiopathic pulmonary fibrosis

(2018) Stephen B Strock et al.   JOURNAL OF PATHOLOGY

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Notch signaling and non-small cell lung cancer (Review)

(2018) Bin Zou et al.   Oncology Letters

The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment

(2018) Mohammad Farhad et al.   OncoImmunology

Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance

(2018) Etienne Giroux-Leprieur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Expression Levels of IL-4/IL-13/STAT6 Signaling Pathway Genes and SOCS3 Could Help to Differentiate the Histopathological Subtypes of Non-Small Cell Lung Carcinoma

(2018) Dorota Pastuszak-Lewandoska et al.   Molecular Diagnosis & Therapy

Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis

(2018) AliReza JafariNezhad et al.   PLoS One

Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis

(2018) Honghui Cao et al.   Scientific Reports

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis

(2018) Maako Ide et al.   Thoracic Cancer

VEGF as a potential target in lung cancer

(2017) Daniela Frezzetti et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Increased frequency of bronchiolar histotypes in lung carcinomas associated with idiopathic pulmonary fibrosis

(2017) Anna Caliò et al.   HISTOPATHOLOGY

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling

(2017) Robert D. Guzy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic profiles of lung cancer associated with idiopathic pulmonary fibrosis

(2017) Ji An Hwang et al.   JOURNAL OF PATHOLOGY

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

(2017) James D McKay et al.   NATURE GENETICS

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

Lung cancer in patients with idiopathic pulmonary fibrosis

(2017) Theodoros Karampitsakos et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The Pulmonary Fibrosis Associated MUC5B Promoter Polymorphism Is Prognostic of the Overall Survival in Patients with Non–Small Cell Lung Cancer (NSCLC) Receiving Definitive Radiotherapy

(2017) Ju Yang et al.   Translational Oncology

Artesunate ameliorates lung fibrosis via inhibiting the Notch signaling pathway

(2017) Yujuan Liu et al.   Experimental and Therapeutic Medicine

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Genetic variations in TERC and TERT genes are associated with lung cancer risk in a Chinese Han population

(2017) Gang Ye et al.   Oncotarget

Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells

(2017) Jun An et al.   Oncotarget

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

(2016) Shobha M. Swamy et al.   AMERICAN JOURNAL OF PATHOLOGY

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

(2016) Melanie Mediavilla-Varela et al.   BMC CANCER

“Scar-cinoma”: viewing the fibrotic lung mesenchymal cell in the context of cancer biology

(2016) Jeffrey C. Horowitz et al.   EUROPEAN RESPIRATORY JOURNAL

Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2

(2016) Xiang Chen et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

GermlineSFTPA1mutation in familial idiopathic interstitial pneumonia and lung cancer

(2016) Nadia Nathan et al.   HUMAN MOLECULAR GENETICS

Clinicopathological, Immunohistochemical, and Genetic Features of Primary Lung Adenocarcinoma Occurring in the Setting of Usual Interstitial Pneumonia Pattern

(2016) Kyohei Masai et al.   Journal of Thoracic Oncology

Pericyte–fibroblast transition promotes tumor growth and metastasis

(2016) Kayoko Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: a randomised, double-blind, placebo-controlled, phase 2 trial

(2016) Jürgen Behr et al.   Lancet Respiratory Medicine

Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

(2016) Xiao-Yan Bai et al.   PLoS One

Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1

(2015) Meredith L. Sosulski et al.   AGING CELL

TOLLIP,MUC5B, and the Response toN-Acetylcysteine among Individuals with Idiopathic Pulmonary Fibrosis

(2015) Justin M. Oldham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SFTPA2Mutations in Familial and Sporadic Idiopathic Interstitial Pneumonia

(2015) Coline H. M. van Moorsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Platelet-Derived Growth Factor Signaling in the Lung. From Lung Development and Disease to Clinical Studies

(2015) Nina Noskovičová et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

(2015) Vanessa J. Craig et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Development of Novel Agents for Idiopathic Pulmonary Fibrosis

(2015) Thomas G. O'Riordan et al.   CHEST

The Impact of Lung Cancer on Survival of Idiopathic Pulmonary Fibrosis

(2015) Sara Tomassetti et al.   CHEST

The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis

(2015) Friedrich Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

The genetic basis of idiopathic pulmonary fibrosis

(2015) Jonathan A. Kropski et al.   EUROPEAN RESPIRATORY JOURNAL

Germline mutations predisposing to non-small cell lung cancer

(2015) Gerald H. Clamon et al.   Familial Cancer

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury

(2015) Megan N. Ballinger et al.   JOURNAL OF IMMUNOLOGY

BRAF Alterations as Therapeutic Targets in Non–Small-Cell Lung Cancer

(2015) Tu Nguyen-Ngoc et al.   Journal of Thoracic Oncology

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

(2015) Bridget D Stuart et al.   NATURE GENETICS

Epigenetics of lung cancer

(2015) Scott M. Langevin et al.   Translational Research

Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with β-catenin

(2015) Ling-Yen Chung et al.   Oncotarget

IL-13 receptor α2 is a negative prognostic factor in human lung cancer and stimulates lung cancer growth in mice

(2015) Mian Xie et al.   Oncotarget

Diagnostic and Prognostic Significances of MUC5B and TTF-1 Expressions in Resected Non-Small Cell Lung Cancer

(2015) Ryo Nagashio et al.   Scientific Reports

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling

(2015) Cuixiang Zhang et al.   Oncotarget

Revealing the Pathogenic and Aging-related Mechanisms of the Enigmatic Idiopathic Pulmonary Fibrosis. An Integral Model

(2014) Moisés Selman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting the Hedgehog–Glioma-Associated Oncogene Homolog Pathway Inhibits Bleomycin-Induced Lung Fibrosis in Mice

(2014) Elika Farrokhi Moshai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

(2014) Claudia Fumarola et al.   BIOCHEMICAL PHARMACOLOGY

Emerging therapeutic interventions for idiopathic pulmonary fibrosis

(2014) Sushmita Chakraborty et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Multiple roles of extracellular fibroblast growth factors in lung cancer cells

(2014) TAKAHIRO SUZUKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Nuclear Receptor Peroxisome Proliferator-activated Receptor-β/δ (PPARβ/δ) Promotes Oncogene-induced Cellular Senescence through Repression of Endoplasmic Reticulum Stress

(2014) Bokai Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial

(2014) Martin Reck et al.   LANCET ONCOLOGY

Radiological Characteristics, Histological Features and Clinical Outcomes of Lung Cancer Patients with Coexistent Idiopathic Pulmonary Fibrosis

(2014) K. A. Khan et al.   LUNG

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Lung Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis Exhibit Genome-Wide Differences in DNA Methylation Compared to Fibroblasts from Nonfibrotic Lung

(2014) Steven K. Huang et al.   PLoS One

Lung cancer in patients with idiopathic pulmonary fibrosis: Clinical characteristics and impact on survival

(2014) Taehoon Lee et al.   RESPIRATORY MEDICINE

How does comorbidity influence survival in idiopathic pulmonary fibrosis?

(2014) Charlotte Hyldgaard et al.   RESPIRATORY MEDICINE

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

The mystery of let-7d – a small RNA with great power

(2014) Tomasz Kolenda et al.   Wspolczesna Onkologia-Contemporary Oncology

Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo

(2014) Ping Wang et al.   OncoTargets and Therapy

Pleural Mesothelial Cell Differentiation and Invasion in Fibrogenic Lung Injury

(2013) Jason S. Zolak et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Bleomycin-induced pulmonary fibrosis is attenuated by an antibody against KL-6

(2013) Ling Xu et al.   EXPERIMENTAL LUNG RESEARCH

Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis

(2013) Anna L. Peljto et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Implicating Exudate Macrophages and Ly-6Chigh Monocytes in CCR2-Dependent Lung Fibrosis following Gene-Targeted Alveolar Injury

(2013) J. J. Osterholzer et al.   JOURNAL OF IMMUNOLOGY

Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition

(2013) Enrico Conte et al.   LABORATORY INVESTIGATION

Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-small-cell lung cancer (START): a randomised, double-blind, phase 3 trial

(2013) Charles Butts et al.   LANCET ONCOLOGY

Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer

(2013) Yuan-zi Ye et al.   MEDICAL ONCOLOGY

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis

(2013) Patricia Almudéver et al.   THORAX

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study

(2013) Imre Noth et al.   Lancet Respiratory Medicine

Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis

(2012) Harikrishna Tanjore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance

(2012) Xiao-wei Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

KRAS Mutations in Lung Cancer

(2012) Niki Karachaliou et al.   Clinical Lung Cancer

High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer

(2012) Miaomiao Yang et al.   EUROPEAN JOURNAL OF CANCER

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

(2012) Isis E Fernandez et al.   LANCET

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs and their vasculature

(2012) Yuval Rinkevich et al.   NATURE CELL BIOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Association between Variations in Cell Cycle Genes and Idiopathic Pulmonary Fibrosis

(2012) Nicoline M. Korthagen et al.   PLoS One

Global Methylation Patterns in Idiopathic Pulmonary Fibrosis

(2012) Einat I. Rabinovich et al.   PLoS One

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells

(2012) Keiko Hisatomi et al.   BMC Pulmonary Medicine

Pathological Alteration of FoxO3a Activity Promotes Idiopathic Pulmonary Fibrosis Fibroblast Proliferation on Type I Collagen Matrix

(2011) Richard Seonghun Nho et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Lysophosphatidic Acid Receptor LPA1Promotes Epithelial Cell Apoptosis after Lung Injury

(2011) Manuela Funke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Survival After Surgery for Pathologic Stage IA Non-Small Cell Lung Cancer Associated With Idiopathic Pulmonary Fibrosis

(2011) Yuichi Saito et al.   ANNALS OF THORACIC SURGERY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lung Cancer: Epidemiology, Etiology, and Prevention

(2011) Charles S. Dela Cruz et al.   CLINICS IN CHEST MEDICINE

Defective Autophagy in Fibroblasts May Contribute to Fibrogenesis in Autoimmune Processes

(2011) Domenico Del Principe et al.   CURRENT PHARMACEUTICAL DESIGN

Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis

(2011) K. K. Mubarak et al.   EUROPEAN RESPIRATORY JOURNAL

Connexins as therapeutic targets in lung disease

(2011) Davide Losa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis

(2011) Max A. Seibold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

(2011) Enrico Conte et al.   PLoS One

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity

(2011) Melanie Königshoff   RESPIRATION

Effect of Nilotinib on Bleomycin-Induced Acute Lung Injury and Pulmonary Fibrosis in Mice

(2011) Chin Kook Rhee et al.   RESPIRATION

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

 -Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix

(2011) A. K. Lovgren et al.   Science Translational Medicine

Prevalence, risk factors and survival of lung cancer in the idiopathic pulmonary fibrosis

(2011) Kyung Jong Lee et al.   Thoracic Cancer

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

(2010) Brett Ley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Idiopathic Pulmonary Fibrosis Is Associated With Endothelial To Mesenchymal Transition

(2010) Dilip Nataraj et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology

(2010) C. Vancheri et al.   EUROPEAN RESPIRATORY JOURNAL

Surfactant Protein A2 Mutations Associated with Pulmonary Fibrosis Lead to Protein Instability and Endoplasmic Reticulum Stress

(2010) Meenakshi Maitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats

(2010) Kenji Adachi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells

(2010) S Bafna et al.   ONCOGENE

DIFFUSE INTERSTITIAL PULMONARY FIBROSIS AND LUNG CANCER

(2010) Toshiaki Kawai et al.   PATHOLOGY INTERNATIONAL

The prevalence of pulmonary fibrosis combined with emphysema in patients with lung cancer

(2010) Kazuhiro USUI et al.   RESPIROLOGY

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

(2009) Maria Teresa Landi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-β1 in vitro

(2009) Najmunnisa Nasreen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors

(2009) J.-C. Soria et al.   ANNALS OF ONCOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model

(2009) Minglun Li et al.   Radiation Oncology

Cumulative incidence of and predictive factors for lung cancer in IPF

(2009) Yuichi OZAWA et al.   RESPIROLOGY

Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

(2008) Yongyu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

(2008) William E. Lawson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thy-1 Promoter Hypermethylation

(2008) Yan Y. Sanders et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Superoxide scavenging activity of pirfenidone–iron complex

(2008) Yoshihiro Mitani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer

(2008) Ji Un Kang et al.   CANCER GENETICS AND CYTOGENETICS

Targeting Growth Factors in Lung Cancer

(2008) Philip S. Hodkinson et al.   CHEST

Potent antioxidant role of Pirfenidone in experimental cirrhosis

(2008) Adriana Salazar-Montes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

(2008) Hisashi Oku et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?

(2008) Moisés Selman et al.   PLOS MEDICINE