Platelet-Derived Growth Factor Signaling in the Lung. From Lung Development and Disease to Clinical Studies

Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis

(2014) Yoshinori Aono et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors

(2014) E. Gabriela Chiorean et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tailored therapeutic strategies for synovial sarcoma: Receptor tyrosine kinase pathway analyses predict sensitivity to the mTOR inhibitor RAD001

(2014) Hirohiko Yasui et al.   CANCER LETTERS

Overexpression of both platelet-derived growth factor-BB and vascular endothelial growth factor-C and its association with lymphangiogenesis in primary human non-small cell lung cancer

(2014) Jiannan Liu et al.   Diagnostic Pathology

Platelet-derived Growth Factor β-Receptor, Transforming Growth Factor β Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

(2014) Helena Porsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of platelet-derived growth factor-BB (PDGF-BB) in human pulmonary artery smooth muscle cell proliferation

(2014) Yan Zhao et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis

(2014) Luca Richeldi et al.   RESPIRATORY MEDICINE

Morphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo

(2013) M.L. Weber et al.   BRITISH JOURNAL OF ANAESTHESIA

Targeting the PDGF signaling pathway in tumor treatment

(2013) Carl-Henrik Heldin   Cell Communication and Signaling

Impression, Sunset

(2013) Marc Humbert   CIRCULATION

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension

(2013) Marius M. Hoeper et al.   CIRCULATION

Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases

(2013) Carl-Henrik Heldin   Journal of Neuroimmune Pharmacology

Analysis of Mice Lacking the Heparin-Binding Splice Isoform of Platelet-Derived Growth Factor A

(2013) J. Andrae et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamic and Nuclear Expression of PDGFR  and IGF-1R in Alveolar Rhabdomyosarcoma

(2013) M. I. Aslam et al.   MOLECULAR CANCER RESEARCH

RNA Interference against Platelet-Derived Growth Factor Receptor α mRNA Inhibits Fibroblast Transdifferentiation in Skin Lesions of Patients with Systemic Sclerosis

(2013) Tong Liu et al.   PLoS One

Functional Cross Talk between CXCR4 and PDGFR on Glioblastoma Cells Is Essential for Migration

(2013) Miriam Sciaccaluga et al.   PLoS One

Repression of PDGF-R-α after cellular injury involves TNF-α, formation of a c-Fos-YY1 complex, and negative regulation by HDAC

(2012) Ning Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Phase II study of pulse dose imatinib mesylate and weekly paclitaxel in patients aged 70 and over with advanced non-small cell lung cancer

(2012) Julie E Bauman et al.   BMC CANCER

Implication of PDGF signaling in cigarette smoke-induced pulmonary arterial hypertension in rat

(2012) Ai-ping Xing et al.   INHALATION TOXICOLOGY

Phf14, a Novel Regulator of Mesenchyme Growth via Platelet-derived Growth Factor (PDGF) Receptor-α

(2012) Michinori Kitagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts

(2012) C. Seikrit et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Wnt ligands signal in a cooperative manner to promote foregut organogenesis

(2012) M. F. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nintedanib (BIBF 1120) for IPF: a tomorrow therapy?

(2012) Sabina A Antoniu   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis

(2011) Sandra Lo Re et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Lymphoid Neogenesis in Idiopathic Pulmonary Arterial Hypertension

(2011) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease

(2011) Dinesh Khanna et al.   ARTHRITIS AND RHEUMATISM

Uridine adenosine tetraphosphate (Up4A) is a strong inductor of smooth muscle cell migration via activation of the P2Y2 receptor and cross-communication to the PDGF receptor

(2011) Annette Wiedon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multitargeted receptor tyrosine kinase inhibition: An antiangiogenic strategy in non-small cell lung cancer

(2011) Mark A. Socinski   CANCER TREATMENT REVIEWS

Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4+ T cells in the broncho-alveolar lavage of patients with systemic sclerosis

(2011) Anagha A. Divekar et al.   CLINICAL IMMUNOLOGY

Immunohistochemical Overexpression of Platelet-Derived Growth Factor Receptor–Beta (PDGFR-β) is Associated With PDGFRB Gene Copy Number Gain in Sarcomatoid Non–Small-Cell Lung Cancer

(2011) Anne S. Tsao et al.   Clinical Lung Cancer

Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D

(2011) Claudia R.C. van Roeyen et al.   KIDNEY INTERNATIONAL

SDF-1  Induces PDGF-B Expression and the Differentiation of Bone Marrow Cells into Pericytes

(2011) R. Hamdan et al.   MOLECULAR CANCER RESEARCH

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity

(2010) Miriam Sciaccaluga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases

(2010) F. Toffalini et al.   BLOOD

Amplification of chromosomal segment 4q12 in non-small cell lung cancer

(2010) Alex H. Ramos et al.   CANCER BIOLOGY & THERAPY

A Novel Signaling Axis of Matriptase/PDGF-D/ -PDGFR in Human Prostate Cancer

(2010) C. V. Ustach et al.   CANCER RESEARCH

Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation

(2010) Aleksandra Jurek et al.   CELLULAR SIGNALLING

Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway

(2010) J. Y. Ye et al.   HAEMATOLOGICA

Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways

(2010) Karen Mendelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet-derived Growth Factor-DD Targeting Arrests Pathological Angiogenesis by Modulating Glycogen Synthase Kinase-3β Phosphorylation

(2010) Anil Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

(2010) Zhongshu Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potential Role of Platelet-Derived Growth Factor Receptor Inhibition Using Imatinib in Combination with Docetaxel in the Treatment of Recurrent Non-small Cell Lung Cancer

(2010) Chao H. Huang et al.   Journal of Thoracic Oncology

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phase II study of sunitinib in men with advanced prostate cancer

(2009) M. Dror Michaelson et al.   ANNALS OF ONCOLOGY

Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer

(2009) T. Donnem et al.   ANNALS OF ONCOLOGY

Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-  Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

(2009) U. McDermott et al.   CANCER RESEARCH

A Dosing/Cross-Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension

(2009) M Gomberg-Maitland et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Generation of bleomycin-induced lung fibrosis is independent of IL-16

(2009) William G. Glass et al.   CYTOKINE

Cell Migration Is Regulated by Platelet-Derived Growth Factor Receptor Endocytosis

(2009) K. Kawada et al.   MOLECULAR AND CELLULAR BIOLOGY

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Platelet-Derived Growth Factor Receptor-Alpha-Expressing Cells Localize to the Alveolar Entry Ring and Have Characteristics of Myofibroblasts During Pulmonary Alveolar Septal Formation

(2008) Stephen E. McGowan et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts

(2008) C. Anderberg et al.   CANCER RESEARCH

Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update

(2008) R. Seggewiss et al.   CYTOTHERAPY

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

(2008) Elizabeth Day et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

Kinetics of repression by modified p53 on the PDGF β-receptor promoter

(2008) Weiwen Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Combined anti-PDGFRα and PDGFRβ targeting in non-small cell lung cancer

(2008) Niels Reinmuth et al.   INTERNATIONAL JOURNAL OF CANCER

Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation

(2008) Aleksandra Jurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Impact of Platelet-Derived Growth Factors in Non-small Cell Lung Cancer Tumor and Stromal Cells

(2008) Tom Donnem et al.   Journal of Thoracic Oncology

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation

(2008) E. Sanchez-Guerrero et al.   NUCLEIC ACIDS RESEARCH

Molecular association between β-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/β-catenin signaling

(2008) G Upadhyay et al.   ONCOGENE

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells

(2008) Erxi Wu et al.   PLoS One

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of platelet-derived growth factor by peripheral-blood leukocytes during experimental allergic encephalomyelitis

(2007) Niklas K. U. Koehler et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A New Look at Platelet-Derived Growth Factor in Renal Disease

(2007) J. Floege et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY