Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

(2019) Chiara Poluzzi et al.   KIDNEY INTERNATIONAL

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan

(2018) Angela Avenoso et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats

(2018) Peter M. Grace et al.   BRAIN BEHAVIOR AND IMMUNITY

Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin

(2018) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Biglycan is a new high-affinity ligand for CD14 in macrophages

(2018) Heiko Roedig et al.   MATRIX BIOLOGY

Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney

(2018) Madalina Viviana Nastase et al.   MATRIX BIOLOGY

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

(2018) Hans-Joachim Anders et al.   Nature Reviews Nephrology

Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function

(2018) Prapaporn Jongwattanapisan et al.   Scientific Reports

Toll-Like Receptors, Inflammation, and Calcific Aortic Valve Disease

(2018) Carmen García-Rodríguez et al.   Frontiers in Physiology

Degenerative aortic valve disease and diabetes: Implications for a link between proteoglycans and diabetic disorders in the aortic valve

(2018) Mareike Barth et al.   Diabetes & Vascular Disease Research

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

(2017) Louise Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells

(2017) Takato Hara et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition

(2017) Patricia G. Wilson et al.   JOURNAL OF LIPID RESEARCH

Osteopontin at the Crossroads of Inflammation and Tumor Progression

(2017) Luigi Mario Castello et al.   MEDIATORS OF INFLAMMATION

Ulcerative colitis, Crohn’s disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn’s disease

(2017) Joachim Høg Mortensen et al.   PLoS One

Loss ofBiglycanEnhances Thrombin Generation inApolipoprotein E-Deficient MiceSignificance

(2016) Maria Grandoch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology

(2016) Liliana Schaefer et al.   FEBS Journal

A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia

(2016) Helena Frey et al.   GLYCOCONJUGATE JOURNAL

The importance of serum biglycan levels as a fibrosis marker in patients with chronic hepatitis B

(2016) Rafiye Ciftciler et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis

(2016) Louise Tzung-Harn Hsieh et al.   MATRIX BIOLOGY

Enhanced biglycan gene expression in the adipose tissues of obese women and its association with obesity-related genes and metabolic parameters

(2016) Jimin Kim et al.   Scientific Reports

Novel Extracellular Matrix Biomarkers as Predictors of Adverse Outcome in Chronic Heart Failure: Association Between Biglycan and Response to Statin Therapy in the CORONA Trial

(2015) Thor Ueland et al.   JOURNAL OF CARDIAC FAILURE

Calcification in Aortic Stenosis

(2015) Tania A. Pawade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism

(2015) Purvi Mehrotra et al.   KIDNEY INTERNATIONAL

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Macrophage migration inhibitory factor induces vascular leakage via autophagy

(2015) H.-R. Chen et al.   Biology Open

Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix

(2014) Edward B. Neufeld et al.   ATHEROSCLEROSIS

Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway

(2014) Rui Song et al.   INFLAMMATION RESEARCH

Soluble biglycan as a biomarker of inflammatory renal diseases

(2014) Louise Tzung-Harn Hsieh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

(2014) Rui Song et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

IL-17A produced by bothγδT and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction

(2014) Xiaogang Peng et al.   JOURNAL OF PATHOLOGY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury

(2014) Kristin Moreth et al.   MATRIX BIOLOGY

Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis

(2014) Susan Y Ritter et al.   ARTHRITIS RESEARCH & THERAPY

Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes

(2014) Florian Kahles et al.   Molecular Metabolism

Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development

(2013) Loren E. Dupuis et al.   DEVELOPMENTAL DYNAMICS

Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?

(2013) Marc R. Dweck et al.   EUROPEAN HEART JOURNAL

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

(2013) Jinyang Zeng-Brouwers et al.   MATRIX BIOLOGY

Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2

(2012) Rui Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

The Biology of Small Leucine-rich Proteoglycans in Bone Pathophysiology

(2012) Dragana Nikitovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket

(2012) S. L. Kelley et al.   JOURNAL OF IMMUNOLOGY

Adipose tissue biglycan as a potential anti-inflammatory target of sodium salicylate in mice fed a high fat diet

(2012) Venkata J Adapala et al.   Journal of Inflammation-London

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Non-Enzymatic Decomposition of Collagen Fibers by a Biglycan Antibody and a Plausible Mechanism for Rheumatoid Arthritis

(2012) Olga Antipova et al.   PLoS One

Biglycan Deletion Alters Adiponectin Expression in Murine Adipose Tissue and 3T3-L1 Adipocytes

(2012) Meliza G. Ward et al.   PLoS One

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Renal Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy

(2011) Joel Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

The HIF Pathway and Erythrocytosis

(2011) Frank S. Lee et al.   Annual Review of Pathology-Mechanisms of Disease

Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin

(2011) M. Ward et al.   CELL PROLIFERATION

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

(2011) Jordan D. Miller et al.   CIRCULATION RESEARCH

Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells

(2011) Javier López et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells

(2011) Yue-Hong Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Proteoglycan Biglycan Enhances Antigen-Specific T Cell Activation Potentially via MyD88 and TRIF Pathways and Triggers Autoimmune Perimyocarditis

(2011) Z. V. Popovic et al.   JOURNAL OF IMMUNOLOGY

Small Leucine-Rich Proteoglycans in Kidney Disease

(2011) L. Schaefer   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

(2011) Sufyan G. Sayyed et al.   KIDNEY INTERNATIONAL

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

(2011) A. D. Berendsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

(2010) Habib Derbali et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential proteoglycan and hyaluronan distribution in calcified aortic valves

(2010) Elizabeth H. Stephens et al.   CARDIOVASCULAR PATHOLOGY

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

(2010) Liliana Schaefer   CURRENT OPINION IN PHARMACOLOGY

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation

(2010) Jesper Hjortnaes et al.   EUROPEAN HEART JOURNAL

Small leucine-rich proteoglycans in atherosclerotic lesions: novel targets of chronic statin treatment?

(2010) Andrea Marzoll et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Networked-based Characterization of Extracellular Matrix Proteins from Adult Mouse Pulmonary and Aortic Valves

(2010) Peggi M. Angel et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments

(2010) Karien J. Rodriguez et al.   MATRIX BIOLOGY

Valvular Heart Disease: Diagnosis and Management

(2010) Kameswari Maganti et al.   MAYO CLINIC PROCEEDINGS

Role of triglyceride-rich lipoproteins in diabetic nephropathy

(2010) John C. Rutledge et al.   Nature Reviews Nephrology

Identification of diabetic nephropathy-selective proteins in human plasma by multi-lectin affinity chromatography and LC-MS/MS

(2010) Jung-Mo Ahn et al.   Proteomics Clinical Applications

Mechanical Strain and the Aortic Valve: Influence on Fibroblasts, Extracellular Matrix, and Potential Stenosis

(2009) Sven Lehmann et al.   ANNALS OF THORACIC SURGERY

Proteoglycans: from structural compounds to signaling molecules

(2009) Liliana Schaefer et al.   CELL AND TISSUE RESEARCH

CD14 but not MD2 transmit signals from DAMP

(2009) Kyung-Hee Chun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2

(2009) Xiaoping Yang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

(2009) Jaklien C. Leemans et al.   PLoS One

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

(2009) P. A. Monach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of valvular interstitial cell calcification by components of the extracellular matrix

(2008) Karien J. Rodriguez et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study

(2008) Hannelore Samyn et al.   JOURNAL OF LIPID RESEARCH

Orchestrating the orchestrators: chemokines in control of T cell traffic

(2008) Shannon K Bromley et al.   NATURE IMMUNOLOGY

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

(2007) Xianzhong Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY