Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology

(2016) Liliana Schaefer et al.   FEBS Journal

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis

(2016) Louise Tzung-Harn Hsieh et al.   MATRIX BIOLOGY

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential

(2016) Masayo Aoki et al.   MEDIATORS OF INFLAMMATION

Sphingosine Kinases: Emerging Structure–Function Insights

(2016) David R. Adams et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1

(2016) Anja Schwiebs et al.   Frontiers in Pharmacology

Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts

(2015) Stephanie Schwalm et al.   BIOLOGICAL CHEMISTRY

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy

(2015) Dania Yaghobian et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes

(2015) Tuoyu Geng et al.   JOURNAL OF LIPID RESEARCH

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

(2014) Madalina V. Nastase et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

(2014) Lisa M. Sedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Soluble biglycan as a biomarker of inflammatory renal diseases

(2014) Louise Tzung-Harn Hsieh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate receptor signaling during acute kidney injury: the tissue is the issue

(2014) Karsten Bartels et al.   KIDNEY INTERNATIONAL

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury

(2014) Kristin Moreth et al.   MATRIX BIOLOGY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

(2014) Kuzhuvelil B Harikumar et al.   NATURE IMMUNOLOGY

Activation of Nuclear Factor Kappa B in the Hepatic Stellate Cells of Mice with Schistosomiasis Japonica

(2014) Xing He et al.   PLoS One

Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases

(2013) Stephanie Schwalm et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Sphingosine 1-Phosphate in Renal Diseases

(2013) Alexander Koch et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation

(2013) Mohamad M. Adada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages

(2013) Yuquan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

(2013) Jinyang Zeng-Brouwers et al.   MATRIX BIOLOGY

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

(2012) Stephanie Schwalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

(2012) K. Alexa Orr Gandy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

Structural Determination and Toll-like Receptor 2-dependent Proinflammatory Activity of Dimycolyl-diarabino-glycerol fromMycobacterium marinum

(2012) Elisabeth Elass-Rochard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan

(2012) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Lipopolysaccharide and Sphingosine-1-Phosphate Cooperate To Induce Inflammatory Molecules and Leukocyte Adhesion in Endothelial Cells

(2012) I. Fernandez-Pisonero et al.   JOURNAL OF IMMUNOLOGY

Renal Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy

(2011) Joel Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

(2011) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sphingosine kinase 1 protects against renal ischemia–reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation

(2011) Sang Won Park et al.   KIDNEY INTERNATIONAL

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

A Novel Mode of Action of the Putative Sphingosine Kinase Inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) Thiazole (SKI II): Induction of Lysosomal Sphingosine Kinase 1 Degradation

(2010) Shuyu Ren et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

(2010) Liliana Schaefer   CURRENT OPINION IN PHARMACOLOGY

The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6

(2010) Dmitri Pchejetski et al.   IMMUNOLOGY AND CELL BIOLOGY

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Sphingosine Kinase-1 (SphK-1) Regulates Mycobacterium smegmatis Infection in Macrophages

(2010) Hridayesh Prakash et al.   PLoS One

Differential regulation of sphingosine kinases 1 and 2 in lung injury

(2009) Raj Wadgaonkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis

(2009) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

(2009) Shuyu Ren et al.   KIDNEY INTERNATIONAL

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

(2008) C. A. Oskeritzian et al.   BLOOD

Divergent roles of sphingosine kinases in kidney ischemia–reperfusion injury

(2008) Sang-Kyung Jo et al.   KIDNEY INTERNATIONAL