Degenerative aortic valve disease and diabetes: Implications for a link between proteoglycans and diabetic disorders in the aortic valve

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

(2017) Louise Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss ofBiglycanEnhances Thrombin Generation inApolipoprotein E-Deficient MiceSignificance

(2016) Maria Grandoch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis

(2015) A. Hultgårdh-Nilsson et al.   JOURNAL OF INTERNAL MEDICINE

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

iTRAQ proteomic analysis of extracellular matrix remodeling in aortic valve disease

(2015) Tatiana Martin-Rojas et al.   Scientific Reports

Increased atherosclerosis in mice with increased vascular biglycan content

(2014) Joel C. Thompson et al.   ATHEROSCLEROSIS

Proteoglycan–LDL interactions: A novel therapeutic target?

(2014) Lisa R. Tannock   ATHEROSCLEROSIS

Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix

(2014) Edward B. Neufeld et al.   ATHEROSCLEROSIS

Biglycan deficiency: Increased aortic aneurysm formation and lack of atheroprotection

(2014) Tao Tang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Global Burden of Aortic Stenosis

(2014) Jeremy J. Thaden et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Review of Molecular and Mechanical Interactions in the Aortic Valve and Aorta: Implications for the Shared Pathogenesis of Aortic Valve Disease and Aortopathy

(2014) Varun K. Krishnamurthy et al.   Journal of Cardiovascular Translational Research

Glycosaminoglycans, Hyperglycemia, and Disease

(2013) Linda M. Hiebert et al.   ANTIOXIDANTS & REDOX SIGNALING

Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development

(2013) Loren E. Dupuis et al.   DEVELOPMENTAL DYNAMICS

Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling

(2013) Ablajan Mahmut et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mitral and aortic valve sclerosis/calcification and carotid atherosclerosis: results from 1065 patients

(2013) Andrea Rossi et al.   HEART AND VESSELS

Arterial Retention of Remnant Lipoproteins Ex Vivo Is Increased in Insulin Resistance Because of Increased Arterial Biglycan and Production of Cholesterol‐Rich Atherogenic Particles That Can Be Improved by Ezetimibe in the JCR:LA‐ cp Rat

(2013) Rabban Mangat et al.   Journal of the American Heart Association

Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2

(2012) Rui Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diagnosis and Classification of Diabetes Mellitus

(2012)   DIABETES CARE

Proteomic Profile of Human Aortic Stenosis: Insights into the Degenerative Process

(2012) Tatiana Martín-Rojas et al.   JOURNAL OF PROTEOME RESEARCH

Diabetes-Induced Alterations in the Extracellular Matrix and Their Impact on Myocardial Function

(2012) Brittany Law et al.   MICROSCOPY AND MICROANALYSIS

Characterization of Porcine Aortic Valvular Interstitial Cell ‘Calcified’ Nodules

(2012) Kristy L. Cloyd et al.   PLoS One

Renal Accumulation of Biglycan and Lipid Retention Accelerates Diabetic Nephropathy

(2011) Joel Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Deficiency of Biglycan Causes Cardiac Fibroblasts to Differentiate into a Myofibroblast Phenotype

(2011) Ariane Melchior-Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

(2010) Habib Derbali et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar human cardiac valves

(2010) Elizabeth H. Stephens et al.   CARDIOVASCULAR PATHOLOGY

Differential proteoglycan and hyaluronan distribution in calcified aortic valves

(2010) Elizabeth H. Stephens et al.   CARDIOVASCULAR PATHOLOGY

TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

(2010) Micah L. Burch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves

(2010) Elaine E. Wirrig et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes

(2010) Sundy N.Y. YANG et al.   Journal of Diabetes

Biglycan and Fibromodulin Have Essential Roles in Regulating Chondrogenesis and Extracellular Matrix Turnover in Temporomandibular Joint Osteoarthritis

(2009) Mildred C. Embree et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts

(2009) Karen Tiede et al.   BASIC RESEARCH IN CARDIOLOGY

Common pathogenic features of atherosclerosis and calcific aortic stenosis: role of transforming growth factor-β

(2009) Songyi Xu et al.   CARDIOVASCULAR PATHOLOGY

Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve

(2008) Elizabeth H. Stephens et al.   Acta Biomaterialia

Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options

(2008) Ashish Aneja et al.   AMERICAN JOURNAL OF MEDICINE

Retrovirally Mediated Overexpression of Glycosaminoglycan-Deficient Biglycan in Arterial Smooth Muscle Cells Induces Tropoelastin Synthesis and Elastic Fiber Formation in Vitro and in Neointimae after Vascular Injury

(2008) Jin-Yong Hwang et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production

(2008) Vivek P. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction

(2008) Liliana Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY