Immunological abnormalities in patients with primary biliary cholangitis

NK cells in autoimmune diseases: Linking innate and adaptive immune responses

(2018) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

The Genetics and Epigenetics of Primary Biliary Cholangitis

(2018) Atsushi Tanaka et al.   Clinics in Liver Disease

Natural killer cell education in human health and disease

(2018) Jeanette E Boudreau et al.   CURRENT OPINION IN IMMUNOLOGY

Environmental basis of primary biliary cholangitis

(2018) Atsushi Tanaka et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation

(2018) Oihane Erice et al.   HEPATOLOGY

The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity

(2018) Heekyong R. Bae et al.   HEPATOLOGY

MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

(2018) Katrin Böttcher et al.   HEPATOLOGY

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

(2018) Santosh Kumar   IMMUNOLOGY

The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7

(2018) Xiang Jiang et al.   JOURNAL OF AUTOIMMUNITY

A cellular and molecular view of T helper 17 cell plasticity in autoimmunity

(2018) Ralph Stadhouders et al.   JOURNAL OF AUTOIMMUNITY

Deficiency in T follicular regulatory cells promotes autoimmunity

(2018) Weiwei Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent reduction of mucosal-associated invariant T cells in primary biliary cholangitis

(2018) Toru Setsu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease

(2018) Kristen M. Valentine et al.   JOURNAL OF IMMUNOLOGY

C1q restrains autoimmunity and viral infection by regulating CD8+T cell metabolism

(2018) Guang Sheng Ling et al.   SCIENCE

Effector T Cells in Multiple Sclerosis

(2018) Belinda J. Kaskow et al.   Cold Spring Harbor Perspectives in Medicine

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

(2018) Yu Tai et al.   Frontiers in Pharmacology

Targeting B Cells and Plasma Cells in Autoimmune Diseases

(2018) Katharina Hofmann et al.   Frontiers in Immunology

The CXC Chemokine Receptor 3 Inhibits Autoimmune Cholangitis via CD8+ T Cells but Promotes Colitis via CD4+ T Cells

(2018) Qing-Zhi Liu et al.   Frontiers in Immunology

T Follicular Helper Cells in Autoimmune Disorders

(2018) Noémie Gensous et al.   Frontiers in Immunology

Unraveling Natural Killer T-Cells Development

(2018) Sabrina Bianca Bennstein   Frontiers in Immunology

Mucosal-Associated Invariant T Cells in Autoimmune Diseases

(2018) Asako Chiba et al.   Frontiers in Immunology

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

(2018) Amit Sharma et al.   Frontiers in Immunology

Pathogen infections and primary biliary cholangitis

(2018) A. Tanaka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Natural Killer Cells: Development, Maturation, and Clinical Utilization

(2018) Alex M. Abel et al.   Frontiers in Immunology

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics

(2017) Toshihiro Tanaka et al.   HEPATOLOGY

Circulating follicular helper T cells presented distinctively different responses toward bacterial antigens in primary biliary cholangitis

(2017) Zun-Qiang Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8+ T cell activation

(2017) Hong-Di Ma et al.   JOURNAL OF AUTOIMMUNITY

Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review

(2017) Wen-Tao Ma et al.   JOURNAL OF AUTOIMMUNITY

Modulation of liver regeneration via myeloid PTEN deficiency

(2017) Wen-Tao Ma et al.   Cell Death & Disease

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

(2017) Fang Qiu et al.   Nature Communications

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells

(2017) Silva Kasela et al.   PLoS Genetics

Macrophage Autophagy and Bacterial Infections

(2017) Aïcha Bah et al.   Frontiers in Immunology

Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System

(2017) Deepti Pilli et al.   Frontiers in Immunology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Heterogeneity of Human CD4+T Cells Against Microbes

(2016) Federica Sallusto   Annual Review of Immunology

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

NKT cell subsets as key participants in liver physiology and pathology

(2016) Keya Bandyopadhyay et al.   Cellular & Molecular Immunology

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Targeting B cells in treatment of autoimmunity

(2016) S Elizabeth Franks et al.   CURRENT OPINION IN IMMUNOLOGY

Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to ursodeoxycholic acid: A proof-of-concept study

(2016) Gideon M. Hirschfield et al.   HEPATOLOGY

Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis

(2016) DONG-YU LIANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

Clonal Characteristics of Circulating B Lymphocyte Repertoire in Primary Biliary Cholangitis

(2016) Yan-guo Tan et al.   JOURNAL OF IMMUNOLOGY

Prevalence of Systemic Sclerosis in Primary Biliary Cholangitis Using the New ACR/EULAR Classification Criteria

(2016) Boyang Zheng et al.   JOURNAL OF RHEUMATOLOGY

Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles

(2016) Frédéric Coutant et al.   Nature Reviews Rheumatology

Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis

(2016) Qingshui Huang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives

(2016) Hannah C. Jeffery et al.   Frontiers in Immunology

Natural Killer Cells and Liver Fibrosis

(2016) Frank Fasbender et al.   Frontiers in Immunology

Regulatory T-cells in autoimmune diseases: Challenges, controversies and—yet—unanswered questions

(2015) Charlotte R. Grant et al.   AUTOIMMUNITY REVIEWS

The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis

(2015) Takashi Tomiyama et al.   Cellular & Molecular Immunology

Elevated circulating CD14lowCD16+ monocyte subset in primary biliary cirrhosis correlates with liver injury and promotes Th1 polarization

(2015) Anping Peng et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The Coexistence of Sjögren's Syndrome and Primary Biliary Cirrhosis: A Comprehensive Review

(2015) Ying Sun et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis

(2015) Yongyin Li et al.   HEPATOLOGY

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis

(2015) Shinji Shimoda et al.   HEPATOLOGY

CXCR5+CD4+T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis

(2015) Lifeng Wang et al.   HEPATOLOGY

The biliary epithelium presents antigens to and activates natural killer T cells

(2015) Elisabeth Schrumpf et al.   HEPATOLOGY

The immunogenetics of primary biliary cirrhosis: A comprehensive review

(2015) G.J. Webb et al.   JOURNAL OF AUTOIMMUNITY

Kupffer Cells Support Hepatitis B Virus–Mediated CD8+T Cell Exhaustion via Hepatitis B Core Antigen–TLR2 Interactions in Mice

(2015) Min Li et al.   JOURNAL OF IMMUNOLOGY

Primary biliary cirrhosis

(2015) Elizabeth J Carey et al.   LANCET

The Distribution and the Fibrotic Role of Elevated Inflammatory Th17 Cells in Patients With Primary Biliary Cirrhosis

(2015) TianYan Shi et al.   MEDICINE

Genome-Wide Association Studies in Primary Biliary Cirrhosis

(2015) Aliya Gulamhusein et al.   SEMINARS IN LIVER DISEASE

RITPBC: B-cell depleting therapy (rituximab) as a treatment for fatigue in primary biliary cirrhosis: study protocol for a randomised controlled trial: Figure 1

(2015) Laura Jopson et al.   BMJ Open

Functional and Phenotypic Plasticity of CD4+T Cell Subsets

(2015) Tiffany Caza et al.   Biomed Research International

Increased activated natural killer T cells in the liver of patients with advancedstage primary biliary cirrhosis

(2014) Yuiko ASO-ISHIMOTO et al.   BIOMEDICAL RESEARCH-TOKYO

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Role and therapeutic value of dendritic cells in central nervous system autoimmunity

(2014) F J Quintana et al.   CELL DEATH AND DIFFERENTIATION

Increased Numbers of Circulating ICOS+ Follicular Helper T and CD38+ Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis

(2014) Li Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis

(2014) Jun Zhang et al.   HEPATOLOGY

Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis

(2014) Minoru Nakamura et al.   HEPATOLOGY RESEARCH

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Clinical Significance of Autoantibodies in Primary Biliary Cirrhosis

(2014) Minoru Nakamura   SEMINARS IN LIVER DISEASE

Autoantibodies in primary biliary cirrhosis: Recent progress in research on the pathogenetic and clinical significance

(2014) Satoshi Yamagiwa   WORLD JOURNAL OF GASTROENTEROLOGY

B-Cell Depletion With Rituximab in Patients With Primary Biliary Cirrhosis Refractory to Ursodeoxycholic Acid

(2013) Robert P Myers et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis

(2013) Gideon M. Hirschfield et al.   Annual Review of Pathology-Mechanisms of Disease

Clinical significance of the fluctuation of primary biliary cirrhosis-related autoantibodies during the course of the disease

(2013) Nikolaos K. Gatselis et al.   AUTOIMMUNITY

Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis

(2013) Cheng Qian et al.   CYTOKINE

Chemokine–Chemokine Receptor CCL2–CCR2 and CX3CL1–CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis

(2013) Motoko Sasaki et al.   DIGESTIVE DISEASES AND SCIENCES

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy

(2013) Chen-Yen Yang et al.   HEPATOLOGY

Splenic lymph follicles generate immunoglobulin M-producing B cells in primary biliary cirrhosis

(2013) Kentaro Kikuchi et al.   HEPATOLOGY RESEARCH

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T-cell directed therapies in liver diseases

(2013) Ye Htun Oo et al.   JOURNAL OF HEPATOLOGY

IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

(2013) Z. Tan et al.   JOURNAL OF IMMUNOLOGY

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

Evaluation of Langerhans Cell Infiltrate by CD1a Immunostain in Liver Biopsy for the Diagnosis of Primary Biliary Cirrhosis

(2012) Rondell P.D. Graham et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid

(2012) P. Manousou et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

(2012) Brittany V. Martin-Murphy et al.   HEPATOLOGY

The immunopathology of liver granulomas in primary biliary cirrhosis

(2012) Zhengrui You et al.   JOURNAL OF AUTOIMMUNITY

Granulomatous liver diseases: A review

(2012) Marcy Coash et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Role of NKT cells in autoimmune liver disease

(2011) Tania Santodomingo-Garzon et al.   AUTOIMMUNITY REVIEWS

Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

(2011) Masanobu Tsuda et al.   HEPATOLOGY

Natural killer cells take two tolls to destruct bile ducts

(2011) Bin Gao et al.   HEPATOLOGY

Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis

(2011) Ana Lleo et al.   HEPATOLOGY

Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

(2011) Shinji Shimoda et al.   HEPATOLOGY

Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis

(2011) Toru Takahashi et al.   HEPATOLOGY

Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid

(2011) Masanobu Tsuda et al.   HEPATOLOGY

T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1

(2011) Weici Zhang et al.   JOURNAL OF AUTOIMMUNITY

Primary biliary cirrhosis and Sjögren’s syndrome: Autoimmune epithelitis

(2011) Carlo Selmi et al.   JOURNAL OF AUTOIMMUNITY

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

(2011) George F Mells et al.   NATURE GENETICS

Progress in the Genetics of Primary Biliary Cirrhosis

(2011) Gideon Hirschfield et al.   SEMINARS IN LIVER DISEASE

Genomics in the Post-GWAS Era

(2011) Brian Juran et al.   SEMINARS IN LIVER DISEASE

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

(2010) Ana Lleo et al.   HEPATOLOGY

Increased Siglec-1 Expression in Monocytes of Patients with Primary Biliary Cirrhosis

(2010) Guangyu Bao et al.   IMMUNOLOGICAL INVESTIGATIONS

Eosinophils and Th2 immunity: contemporary insights

(2010) Lisa A Spencer et al.   IMMUNOLOGY AND CELL BIOLOGY

Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis

(2010) Francesca Bernuzzi et al.   JOURNAL OF AUTOIMMUNITY

Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis

(2010) Motoko Sasaki et al.   JOURNAL OF HEPATOLOGY

Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3α in the pathogenesis of primary biliary cirrhosis

(2010) Kenichi Harada et al.   LIVER INTERNATIONAL

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

(2010) Xiangdong Liu et al.   NATURE GENETICS

Experimental evidence on the immunopathogenesis of primary biliary cirrhosis

(2009) Carlo Selmi et al.   Cellular & Molecular Immunology

Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population

(2009) G. Rong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis

(2009) K. Harada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate Immunity and Primary Biliary Cirrhosis

(2009) Carlo Selmi et al.   CURRENT MOLECULAR MEDICINE

CX3CL1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosis

(2009) Shinji Shimoda et al.   HEPATOLOGY

Apotopes and the biliary specificity of primary biliary cirrhosis

(2009) Ana Lleo et al.   HEPATOLOGY

Clustering and commonalities among autoimmune diseases

(2009) Ian R. Mackay   JOURNAL OF AUTOIMMUNITY

A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis

(2009) Nancy Agmon-Levin et al.   JOURNAL OF AUTOIMMUNITY

Primary Biliary Cirrhosis Associated withHLA, IL12A,andIL12RB2Variants

(2009) Gideon M. Hirschfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver biopsy in primary biliary cirrhosis: Clinicopathological data and stage

(2009) Uta Drebber et al.   PATHOLOGY INTERNATIONAL

Is autoimmunity a matter of sex?

(2008) Ana Lleo et al.   AUTOIMMUNITY REVIEWS

Interstitial lung disease and Sjögren’s syndrome in primary biliary cirrhosis: a causal or casual association?

(2008) Bin Liu et al.   CLINICAL RHEUMATOLOGY

Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells

(2008) Shinji Shimoda et al.   HEPATOLOGY

CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis

(2008) Shinji Shimoda et al.   JOURNAL OF AUTOIMMUNITY

Hepatic IL-17 responses in human and murine primary biliary cirrhosis

(2008) Ruth Y.Z. Lan et al.   JOURNAL OF AUTOIMMUNITY

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

(2008) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA