Natural Killer Cells and Liver Fibrosis

Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

(2016) Kelly Hudspeth et al.   JOURNAL OF AUTOIMMUNITY

Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s

(2016) Ling Tang et al.   JOURNAL OF AUTOIMMUNITY

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

(2015) Zhixia Zhou et al.   CANCER LETTERS

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

NKp30 isoforms in patients with chronic hepatitis C virus infection

(2015) Stefania Mantovani et al.   IMMUNOLOGY

Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type

(2015) Bettina Langhans et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a+NK Cells

(2015) Nicole Marquardt et al.   JOURNAL OF IMMUNOLOGY

Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population

(2015) Theresa Hydes et al.   LANCET

Antigen-specific NK cell memory in rhesus macaques

(2015) R Keith Reeves et al.   NATURE IMMUNOLOGY

NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure

(2015) Yong Zou et al.   PLoS One

PLZF expression maps the early stages of ILC1 lineage development

(2015) Michael G. Constantinides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-examining the origin and function of liver-resident NK cells

(2015) Hui Peng et al.   TRENDS IN IMMUNOLOGY

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

(2014) Seddik Hammad et al.   ARCHIVES OF TOXICOLOGY

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

(2014) Freimut Schliess et al.   HEPATOLOGY

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow

(2014) Cécile Daussy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis

(2014) Dirk Drasdo et al.   JOURNAL OF HEPATOLOGY

CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets

(2014) M. T. M. Vossen et al.   JOURNAL OF IMMUNOLOGY

TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency

(2014) Sara Fernández-Álvarez et al.   LABORATORY INVESTIGATION

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

Tissue-resident natural killer cells and their potential diversity

(2014) Dorothy K. Sojka et al.   SEMINARS IN IMMUNOLOGY

Advances in liver regeneration

(2014) George K Michalopoulos   Expert Review of Gastroenterology & Hepatology

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

The role of natural killer cells in autoimmune liver disease: A comprehensive review

(2013) Kelly Hudspeth et al.   JOURNAL OF AUTOIMMUNITY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

(2013) Hui Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired CD4+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients

(2013) Andreas Glässner et al.   JOURNAL OF HEPATOLOGY

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

(2013) Atsuhiro Matsumoto et al.   PLoS One

NK Cell Isolation from Liver Biopsies: Phenotypic and Functional Analysis of Low Cell Numbers by Flow Cytometry

(2013) Ning Li et al.   Frontiers in Immunology

Natural killer and natural killer T cells in liver fibrosis

(2012) Bin Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse

(2012) Akihito Okazaki et al.   HEPATOLOGY

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

(2012) Scott M. Gordon et al.   IMMUNITY

Migration of lymphocytes into hepatic sinusoids

(2012) Ian N. Crispe   JOURNAL OF HEPATOLOGY

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

(2012) Andreas Glässner et al.   LABORATORY INVESTIGATION

TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence

(2012) Cheng Sun et al.   PLoS Pathogens

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer

(2011) K. Aalto et al.   BLOOD

Early Changes in Natural Killer Cell Function Indicate Virologic Response to Interferon Therapy for Hepatitis C

(2011) Golo Ahlenstiel et al.   GASTROENTEROLOGY

NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis

(2011) Chamutal Gur et al.   GUT

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

(2011) Won-Il Jeong et al.   HEPATOLOGY

Interferon-α–Induced TRAIL on Natural Killer Cells Is Associated With Control of Hepatitis C Virus Infection

(2010) Kerstin A. Stegmann et al.   GASTROENTEROLOGY

Amelioration of hepatic fibrosis by NK cell activation

(2010) N. Muhanna et al.   GUT

Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation

(2010) Viviana Moroso et al.   LIVER TRANSPLANTATION

Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

(2010) Silke Paust et al.   NATURE IMMUNOLOGY

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Hepatocyte-specific NEMO deletion promotes NK/NKT cell– and TRAIL-dependent liver damage

(2009) Naiara Beraza et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Killing of Liver NK Cells by Fas/Fas Ligand and NKG2D/NKG2D Ligand Contributes to Hepatocyte Necrosis in Virus-Induced Liver Failure

(2009) Yong Zou et al.   JOURNAL OF IMMUNOLOGY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide

(2008) Mary Jane Masson et al.   HEPATOLOGY

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

(2008) Magali Terme et al.   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis

(2007) Won–Il Jeong et al.   GASTROENTEROLOGY