Effector T Cells in Multiple Sclerosis

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation

(2016) Catharina C. Gross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deleterious versus protective autoimmunity in multiple sclerosis

(2015) Milos Kostic et al.   CELLULAR IMMUNOLOGY

Nonapoptotic and Extracellular Activity of Granzyme B Mediates Resistance to Regulatory T Cell (Treg) Suppression by HLA-DR−CD25hiCD127loTregs in Multiple Sclerosis and in Response to IL-6

(2015) Siddheshvar Bhela et al.   JOURNAL OF IMMUNOLOGY

Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes

(2015) Guillaume Perriard et al.   Journal of Neuroinflammation

FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients

(2015) M T Cencioni et al.   Cell Death & Disease

Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation

(2015) Payton A. Ottum et al.   Frontiers in Immunology

Interferon-γ Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis

(2014) Chen Ni et al.   AMERICAN JOURNAL OF PATHOLOGY

JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis

(2014) Spyridon Chalkias et al.   ANNALS OF NEUROLOGY

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

(2014) Gaelle Elain et al.   GLIA

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β

(2014) Simona Rolla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MRI phenotypes based on cerebral lesions and atrophy in patients with multiple sclerosis

(2014) Shahamat Tauhid et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies

(2014) Dean M. Wingerchuk et al.   MAYO CLINIC PROCEEDINGS

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

(2014) Sung S. Choi et al.   PLoS One

IL-17 and Glutamate Excitotoxicity in the Pathogenesis of Multiple Sclerosis

(2014) M. Kostic et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immune privilege of the CNS is not the consequence of limited antigen sampling

(2014) Melissa G. Harris et al.   Scientific Reports

CD8+T cells in multiple sclerosis

(2013) Aleksandar Denic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis

(2013) Wen Xu et al.   JOURNAL OF NEUROIMMUNOLOGY

The transcriptional landscape of αβ T cell differentiation

(2013) Michael Mingueneau et al.   NATURE IMMUNOLOGY

In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6-Mediated Signaling

(2013) A. Schneider et al.   Science Translational Medicine

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Janus-like effects of type I interferon in autoimmune diseases

(2012) Robert C. Axtell et al.   IMMUNOLOGICAL REVIEWS

Increased HLA-E expression in white matter lesions in multiple sclerosis

(2012) Pascal F. Durrenberger et al.   IMMUNOLOGY

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Cytotoxicity of CD56bright NK Cells towards Autologous Activated CD4+ T Cells Is Mediated through NKG2D, LFA-1 and TRAIL and Dampened via CD94/NKG2A

(2012) Natasja Nielsen et al.   PLoS One

IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain

(2011) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Impaired suppression of synovial fluid CD4+CD25− T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells

(2011) Susanne Haufe et al.   ARTHRITIS AND RHEUMATISM

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

(2011) E. J. Wehrens et al.   BLOOD

CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis

(2011) Viviana Annibali et al.   BRAIN

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

(2011) Cheryl M. Sweeney et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune tolerance in multiple sclerosis

(2011) Joan M. Goverman   IMMUNOLOGICAL REVIEWS

Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis

(2011) Ethan J. Baughman et al.   JOURNAL OF AUTOIMMUNITY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Th1 and Th17 cells

(2010) Jesse M. Damsker et al.   Annals of the New York Academy of Sciences

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner

(2010) Daniel D. Pinschewer et al.   BRAIN

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

(2010) Chen S Tan et al.   LANCET NEUROLOGY

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins

(2010) Sara Salinas et al.   NATURE REVIEWS MICROBIOLOGY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

Pathogenic CD8+T cells in multiple sclerosis

(2009) Manuel A. Friese et al.   ANNALS OF NEUROLOGY

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?

(2009) Erin E Longbrake et al.   Expert Review of Neurotherapeutics

Regulatory T cells overturned: the effectors fight back

(2009) Lucy S. K. Walker   IMMUNOLOGY

IFN-  Inhibits Human Th17 Cell Differentiation

(2009) V. S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

CD8 T Cells Producing IL-17 and IFN-γ Initiate the Innate Immune Response Required for Responses to Antigen Skin Challenge

(2009) Danielle D. Kish et al.   JOURNAL OF IMMUNOLOGY

Increased resistance to CD4+CD25hiregulatory T cell-mediated suppression in patients with type 1 diabetes

(2008) J. M. Lawson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells

(2008) Monica Montes et al.   CLINICAL IMMUNOLOGY

IL17 and IFNγ production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis

(2008) Giovanni Frisullo et al.   CYTOKINE

Blood CD8+T cell responses against myelin determinants in multiple sclerosis and healthy individuals

(2008) Laureline Berthelot et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

Role of Th1 and Th17 cells in organ-specific autoimmunity

(2008) Valérie Dardalhon et al.   JOURNAL OF AUTOIMMUNITY

Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis

(2008) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunological decision-making: how does the immune system decide to mount a helper T-cell response?

(2007) Gerard E. Kaiko et al.   IMMUNOLOGY