Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

New horizons for cystic fibrosis treatment

(2017) Isabelle Fajac et al.   PHARMACOLOGY & THERAPEUTICS

New studies about the insertion mechanism of Thymosin α1 in negative regions of model membranes as starting point of the bioactivity

(2016) Walter Mandaliti et al.   AMINO ACIDS

A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

(2016) A Tosco et al.   CELL DEATH AND DIFFERENTIATION

Serum thymosin α 1 levels in patients with chronic inflammatory autoimmune diseases

(2016) F. Pica et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Early pulmonary disease manifestations in cystic fibrosis mice

(2016) Rebecca J. Darrah et al.   Journal of Cystic Fibrosis

Aspergillus infections in cystic fibrosis

(2016) Jill King et al.   JOURNAL OF INFECTION

Spatiotemporal Resolution of Rab9 and CI-MPR Dynamics in the Endocytic Pathway

(2016) Ana Kucera et al.   TRAFFIC

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(2016) Rossana G. Iannitti et al.   Nature Communications

New and emerging targeted therapies for cystic fibrosis

(2016) Bradley S Quon et al.   BMJ-British Medical Journal

New and emerging targeted therapies for cystic fibrosis

(2016) Bradley S Quon et al.   BMJ-British Medical Journal

Targeting Molecular Chaperones for the Treatment of Cystic Fibrosis: Is It a Viable Approach?

(2015) Ashley Heard et al.   CURRENT DRUG TARGETS

Evaluation of thymosin α 1 in nonclinical models of the immune-suppressing indications melanoma and sepsis

(2015) Robert S King et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Origins of Cystic Fibrosis Lung Disease

(2015) David A. Stoltz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

IDO-GCN2 and autophagy in inflammation

(2015) Tracy L. McGaha   Oncotarget

Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells

(2015) Monica Sala-Rabanal et al.   eLife

Unravelling druggable signalling networks that control F508del-CFTR proteostasis

(2015) Ramanath Narayana Hegde et al.   eLife

CFTR and lung homeostasis

(2014) James F. Collawn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

(2014) Daniela De Stefano et al.   Autophagy

Tissue damage control in disease tolerance

(2014) Miguel P. Soares et al.   TRENDS IN IMMUNOLOGY

A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial

(2014) Michael P Boyle et al.   Lancet Respiratory Medicine

Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines

(2013) Rossana G. Iannitti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator

(2013) V R Villella et al.   CELL DEATH AND DIFFERENTIATION

Cystic Fibrosis Therapeutics

(2013) Lucas R. Hoffman et al.   CHEST

Effect of ivacaftor on CFTR forms with missense mutations associated with defects in protein processing or function

(2013) Fredrick Van Goor et al.   Journal of Cystic Fibrosis

Crosstalk between Autophagy and Inflammasomes

(2013) Jae-Min Yuk et al.   MOLECULES AND CELLS

Managing the Underlying Cause of Cystic Fibrosis: A Future Role for Potentiators and Correctors

(2013) Luis J. V. Galietta   PEDIATRIC DRUGS

The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins

(2012) Emmanuel Taillebourg et al.   Autophagy

CD4+ T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

(2012) Antonella De Luca et al.   JOURNAL OF CLINICAL INVESTIGATION

Ivacaftor potentiation of multiple CFTR channels with gating mutations

(2012) Haihui Yu et al.   Journal of Cystic Fibrosis

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Corticosteroids in Respiratory Diseases in Children

(2011) Fernando M. de Benedictis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CFTR: folding, misfolding and correcting the ΔF508 conformational defect

(2011) Gergely L. Lukacs et al.   TRENDS IN MOLECULAR MEDICINE

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO

(2010) Antonella de Luca et al.   Cellular & Molecular Immunology

Association of the CLCA1 p.S357N Variant With Meconium Ileus in European Patients With Cystic Fibrosis

(2010) HPJ van der Doef et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Autophagy: links with the proteasome

(2009) Trond Lamark et al.   CURRENT OPINION IN CELL BIOLOGY

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

(2009) Gerco C Hassink et al.   EMBO REPORTS

From lab to bedside: emerging clinical applications of thymosin α1

(2009) Allan L Goldstein et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The Deubiquitinating Enzyme USP10 Regulates the Post-endocytic Sorting of Cystic Fibrosis Transmembrane Conductance Regulator in Airway Epithelial Cells

(2009) Jennifer M. Bomberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

(2009) Liqun Zhang et al.   PLOS BIOLOGY

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE