Article
Rheumatology
Ketian Li, Wenxiu Mo, Lijun Wu, Xunyao Wu, Cainan Luo, Xinyue Xiao, Xinmiao Jia, Huaxia Yang, Yunyun Fei, Hua Chen, Fengchun Zhang, Yongzhe Li, Lidan Zhao, Xuan Zhang
Summary: This study identified nine novel autoantibodies in ACPA-negative RA, with anti-PTX3 and anti-DUSP11 showing the highest sensitivity. The combination of these two autoantibodies significantly increased the diagnostic sensitivity in ACPA-negative RA. The novel biomarkers provide potential diagnostic value for ACPA-negative RA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Kristina Sejersen, Tomas Weitoft, Ann Knight, Jorgen Lysholm, Anders Larsson, Johan Ronnelid
Summary: The aim of this study was to evaluate the performance of the granulocyte protein calprotectin as an inflammatory biomarker in knee synovitis of RA patients. The study found that serum calprotectin had a stronger correlation with inflammatory markers and disease activity, while synovial fluid (SF) calprotectin was mainly correlated with white blood cell count and polymorphonuclear cell count in the SF. Serum calprotectin showed a particularly strong association with inflammation in ACPA positive RA patients. Measurement of calprotectin in SF did not provide any additional benefit compared to measurement in the circulation in RA patients with knee synovitis.
Article
Medicine, General & Internal
Vincent Ricchiuti, Kelly Y. Chun, Jane M. Yang, Mary Ann Aure, Luis Gomez, Gary L. Norman, Michael Mahler
Summary: Anti-carbamylated protein (CarP) antibodies can serve as novel markers for the diagnosis and prognosis of rheumatoid arthritis. The study found that anti-CarP antibodies can be detected in both anti-cyclic citrullinated peptide (CCP), rheumatoid factor (RF), and 14-3-3 eta-positive and negative patients, potentially identifying specific subsets of patients.
Article
Immunology
Minjie Xu, Rong Du, Wenping Xing, Xueting Chen, Jian Wan, Shengqing Wang, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Hui Geng
Summary: Citrullinated neoepitopes have been identified as key triggers for the synthesis of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients. This study investigated the expression of citrullinated proteins and enzymes in human platelets and platelet-derived microparticles (PDP). The results revealed the presence of citrullinated autoantigens in platelets and PDPs, suggesting that they could be potential targets for ACPA in RA. These findings provide valuable insights into the role of platelets in triggering ACPA production in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Xanthe Marijn Edmee Matthijssen, Fenne Wouters, Navkiran Sidhu, Ellis Niemantsverdriet, Annette van der Helm-van Mil
Summary: MRI-detected tenosynovitis shows high sensitivity for early ACPA-positive and ACPA-negative RA, indicating that involvement of both juxta-articular (tenosynovitis) and intra-articular synovium is characteristic of RA. Sensitivity for RA is significantly higher than other diseases associated with enthesitis, such as spondyloarthritis and psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Bogdan Kolarz, Marek Ciesla, Ann K. Rosenthal, Magdalena Dryglewska, Maria Majdan
Summary: This study found that anti-CarP may serve as an effective biomarker for identifying ACPA/RF negative RA patients, helping to identify individuals who may benefit from early aggressive therapy. In the RA population, some patients have multiple types of antibodies concurrently, while there is no correlation between ACPA and anti-CarP.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jenn-Haung Lai
Summary: RA is a chronic inflammatory disease involving synovial inflammation and articular destruction. RFs, ACPAs, and anti-CarP Abs have been identified as important autoantibodies in predicting and diagnosing RA, with potential implications for treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zhaojun Liang, Nan Wang, Lili Shang, Yanlin Wang, Min Feng, Guangying Liu, Chong Gao, Jing Luo
Summary: The study found differences in peripheral CD4(+) T cell subsets between ACPA(+) and ACPA(-) RA patients, showing that MMP-3 could potentially serve as a marker for early diagnosis and evaluation of ACPA(-) RA. Additionally, MMP-3 was identified as an important index for assessing RA disease activity, stratification, and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Ketian Li, Min Wang, Lidan Zhao, Yudong Liu, Xuan Zhang
Summary: This review summarizes the current knowledge about the primary drivers of ACPA(-) RA, focusing on the serological, cellular, and molecular aspects of immune mechanisms. A better understanding of the etiology of ACPA(-) RA will aid in personalized treatment design and improve early treatment and outcomes.
Article
Allergy
Ru-Xuan Chen, Li-Dan Zhao, Xin-Yue Xiao, Lan Song, Hua-Yang Du, Zuo-Jun Xu, Rui-E Feng, Hua-Xia Yang, Yun-Yun Fei, Wen Zhang, Feng-Chun Zhang, Hua Chen, Xuan Zhang
Summary: ILD-onset RA-ILD shows more stable ILD compared to arthritis-onset RA-ILD, with older age at ILD diagnosis and UIP pattern associated with ILD progression. In ACPA-positive ILD-only patients, positive RF is an independent risk factor for developing arthritis in the future.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Weronika Kurowska, Iwona Slowinska, Zbigniew Krogulec, Piotr Syrowka, Wlodzimierz Maslinski
Summary: The presence of anti-citrullinated protein antibodies (ACPAs) in the bone marrow of rheumatoid arthritis (RA) patients is associated with increased osteoclast activation and bone resorption. Higher levels of IL-8 in bone marrow containing anti-CCP Abs may play a role in ACPA-induced bone resorption. Levels of TRAP5b, cathepsin K, CTX-I, and IL-8 are elevated in bone marrow compared to peripheral blood, indicating local generation of these molecules.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Xanthe M. E. Matthijssen, Ellis Niemantsverdriet, Saskia Le Cessie, Annette H. M. Van der Helm-van Mil
Summary: This study found that the decrease of inflammatory features usually occurs simultaneously in patients with RA and undifferentiated arthritis, including in ACPA subgroups, but synovitis decrease typically precedes tenosynovitis decrease. Additionally, in ACPA-positive patients, synovitis decrease occurs before osteitis decrease.
Article
Rheumatology
Lieve Van Hoovels, Bert Vander Cruyssen, Daniela Sieghart, Carolien Bonroy, Eszter Nagy, Rille Pullerits, Sasa Cucnik, Charlotte Dahle, Ingmar Heijnen, Luca Bernasconi, Farid Benkhadra, Laura Bogaert, Stefanie Van den Bremt, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Ruediger Mueller, Diego Kyburz, Christopher Sjowall, Alf Kastbom, Rok Jese, Boja Jovancevic, Emese Kiss, Peggy Jacques, Daniel Aletaha, Guenter Steiner, Patrick Verschueren, Xavier Bossuyt
Summary: This study aimed to refine the interpretation of RF and ACPA across commercial assays. By determining thresholds for antibody levels and assigning test result interval-specific LRs, clinical interpretation can be aligned for all RF and ACPA assays.
Article
Rheumatology
Alice Combier, Camelia Frantz, Julien Wipff, Romain Bazeli, Muriel Elhai, Antoine Feydy, Pierre Quartier, Gertrude Touanga Ngoti, Marion Thomas, Chantal Deslandre, Jerome Avouac, Yannick Allanore
Summary: This study aimed to determine whether anti-citrullinated peptide antibodies (ACPA) could be of value to assess structural damage in polyarticular juvenile idiopathic arthritis (pJIA) persisting in adulthood. Retrospectively including pJIA patients with available ACPA, rheumatoid factor (RF), and X-ray data, it was found that ACPA positivity was significantly associated with RF positivity and correlated with structural damage.
Article
Immunology
Guillaume Larid, Mikael Pancarte, Geraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Guy Serre, Nathalie Balandraud
Summary: In this study of 184 ACPA-positive RA patients, it was found that anti-alpha 505-515cit antibodies were associated with HLA-DRB1*04:01, and high levels of these antibodies were associated with rheumatoid nodules. This suggests that immune complexes containing these antibodies may play a role in the development of rheumatoid nodules, offering a new therapeutic opportunity for patients with this condition.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Sarah J. H. Khidir, Anna M. P. Boeren, Annelies Boonen, Pascal H. P. de Jong, Elise van Mulligen, Annette H. M. van der Helm-van Mil
Summary: This study provides evidence that lower educational attainment is associated with a higher risk of progressing from arthralgia to inflammatory arthritis (IA). This effect is partially mediated by subclinical joint inflammation.
Letter
Rheumatology
C. Rogier, M. C. Kortekaas, A. H. M. van der Helm-van Mil, P. H. P. de Jong, E. van Mulligen
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Marc P. Maurits, Fenne Wouters, Ellis Niemantsverdriet, Thomas W. J. Huizinga, Erik B. van den Akker, Saskia Le Cessie, Annette H. M. van Der Helm-van Mil, Rachel Knevel
Summary: This study investigates the differentiation of established genetic predictors for rheumatoid arthritis (RA) in healthy controls, patients with clinically suspect arthralgia (CSA), and RA patients. The study finds that genetic predisposition increases across pre-RA participant groups and that HLA shared epitope (HLA-SE) is more prevalent in RA patients. Genetics seem to play different etiological roles in arthritis patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Quirine A. Dumoulin, Marloes Verstappen, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Mikhail Volkov, Maximilian Brinkhaus, Karin A. van Schie, Albert Bondt, Theresa Kissel, Elvera J. van der Kooi, Arthur E. H. Bentlage, Carolien A. M. Koeleman, Steven W. de Taeye, Ninotska I. Derksen, Radboud J. E. M. Dolhain, Ute Braig-Scherer, Tom W. J. Huizinga, Manfred Wuhrer, Rene E. M. Toes, Gestur Vidarsson, Diane van der Woude
Summary: Glycosylation in the Fc and Fab regions of antibodies can affect their function and binding. Fab glycans negatively impact the interaction between IgG and hFcRn and reduce the transport of IgG across the placenta. Fab-glycosylated antibodies are frequently associated with autoimmune and malignant disorders and may have potential harmful effects.
JOURNAL OF IMMUNOLOGY
(2023)
Review
Rheumatology
Theresa Kissel, Rene E. M. Toes, Thomas W. J. Huizinga, Manfred Wuhrer
Summary: Glycosylation is a common modification that affects protein stability and interactions. It plays a significant role in rheumatic diseases, influencing inflammatory processes and disease progression. Understanding the impact of glycosylation on plasma proteins, cells, and tissues opens up potential interventions for the treatment of these diseases.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Rheumatology
Sophie I. E. Liem, Sam Neppelenbroek, Cynthia M. Fehres, Corrie Wortel, Rene E. M. Toes, Tom W. J. Huizinga, Hans U. Scherer, Jeska K. de Vries-Bouwstra
Summary: A hallmark of disease pathogenesis of systemic sclerosis (SSc) is the presence of autoreactive B cell responses targeting nuclear proteins. Autoantibodies serve as diagnostic biomarkers in SSc and can help identify clinical phenotypes of the disease. Understanding the contribution of antinuclear autoantibodies and their underlying B cell response is crucial in the management and treatment of SSc.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Orthopedics
Anna M. P. Boeren, Ellis Niemantsverdriet, Marloes Verstappen, Fenne Wouters, Johannes L. Bloem, Monique Reijnierse, Annette H. M. van der Helm-van Mil
Summary: Objective MRI of small joints is crucial for early detection and treatment of rheumatoid arthritis. A modified Dixon sequence is introduced to improve the feasibility of MRI implementation in clinical practice, which does not require contrast and reduces total acquisition time. The results show good reliability and correlation between the modified Dixon and conventional sequences.
SKELETAL RADIOLOGY
(2023)
Article
Rheumatology
Sarah J. H. Khidir, Maaike Boonstra, Sytske Anne Bergstra, Gerry W. M. Boerrigter, Elles M. Voog-van der Harst, Maarten K. Ninaber, Nina Ajmone Marsan, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil, Jeska K. de Vries-Bouwstra
Summary: This study aimed to investigate the course of maximal mouth opening in systemic sclerosis patients and determine the factors associated with smaller maximal mouth opening over time. The results showed that a majority of patients had stable maximal mouth opening, but those with more severe organ involvement had a smaller maximal mouth opening over time. Smaller maximal mouth opening was also associated with more mouth handicap.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Letter
Rheumatology
Jacopo Ciaffi, Sophie I. E. Liem, Nina M. van Leeuwen, Cornelia F. Allaart, Tom W. J. Huizinga, Jeska K. de Vries-Bouwstra
Letter
Rheumatology
Doortje Krijbolder, Fenne Wouters, Ellis Niemantsverdriet, Annette H. M. van der Helm-van Mil
Article
Rheumatology
Sascha L. Heckert, Petra C. E. Hissink-Muller, J. Merlijn van den Berg, Dieneke Schonenberg-Meinema, Lisette W. A. van Suijlekom-Smit, Marion A. J. van Rossum, Yvonne Koopman, Rebecca ten Cate, Danielle M. C. Brinkman, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: We studied the patterns of joint inflammation in JIA and found that joints with inflammation at disease onset tend to have recurrent episodes of inflammation during follow-up. This suggests that local factors may contribute to the occurrence of JIA flares.
Article
Rheumatology
Doortje Isabelle Krijbolder, Sarah J. H. Khidir, Xanthe M. E. Matthijssen, Robin M. ten Brinck, Jill van Aken, Irene Speyer, Florus J. van der Giesen, Elise van Mulligen, Annette H. M. van der Helm-van Mil
Summary: In patients with clinically suspect arthralgia (CSA), hand function is often impaired before the development of rheumatoid arthritis (RA), and this impairment is associated with subclinical inflammation and tenosynovitis in particular.
Article
Rheumatology
Sarah J. H. Khidir, Bastiaan T. van Dijk, Doortje Krijbolder, Marloes Verstappen, Elise van Mulligen, Annette H. M. van der Helm-van Mil
Summary: This study investigated the progression of rheumatoid arthritis (RA) from clinically suspect arthralgia (CSA) and found that hand disabilities occur earlier and more frequently than foot disabilities. Additionally, a single question on hand functioning can predict future development of RA.
Article
Rheumatology
Emma C. de Moel, Leendert A. Trouw, Chikashi Terao, Nimmisha Govind, Mohammed Tikly, Hani El-Gabalawy, Irene Smolik, Holger Bang, Tom W. J. Huizinga, Rene E. M. Toes, Diane van der Woude
Summary: Rheumatoid arthritis (RA) occurs in different ethnic populations worldwide. This study revealed that anti-modified protein antibodies (AMPA) can be detected in RA patients across different continents and ethnicities, suggesting a common pathway involved in AMPA development. However, differences in AMPA levels and associated factors were observed among the different populations.
ARTHRITIS RESEARCH & THERAPY
(2023)
