B Cells in Rheumatoid Arthritis: From Pathogenic Players to Disease Biomarkers

B Lymphocyte Autoimmunity in Rheumatoid Synovitis Is Independent of Ectopic Lymphoid Neogenesis

(2014) T. Cantaert et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks

(2014) J. H. Anolik et al.   JOURNAL OF IMMUNOLOGY

High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease

(2014) Serena Bugatti et al.   RHEUMATOLOGY

B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis

(2013) Laetitia Rapetti et al.   ANNALS OF THE RHEUMATIC DISEASES

Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies

(2013) Arnd Kleyer et al.   ANNALS OF THE RHEUMATIC DISEASES

The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis

(2013) L G M van Baarsen et al.   ANNALS OF THE RHEUMATIC DISEASES

Differences in bone structure between rheumatoid arthritis and psoriatic arthritis patients relative to autoantibody positivity

(2013) Roland Kocijan et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

(2013) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

CCL19, a B Cell Chemokine, Is Related to the Decrease of Blood Memory B Cells and Predicts the Clinical Response to Rituximab in Patients With Rheumatoid Arthritis

(2013) Jérémie Sellam et al.   ARTHRITIS AND RHEUMATISM

Modulating the co-stimulatory signal for T cell activation in rheumatoid arthritis: Could it be the first step of the treatment?

(2013) Roberto Caporali et al.   AUTOIMMUNITY REVIEWS

Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis

(2013) Liang Ma et al.   CLINICAL RHEUMATOLOGY

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cells Contribute to Heterogeneity of IL-17 Producing Cells in Rheumatoid Arthritis and Healthy Controls

(2013) Paul Martin Schlegel et al.   PLoS One

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Global Molecular Effects of Tocilizumab Therapy in Rheumatoid Arthritis Synovium

(2013) Julie Ducreux et al.   Arthritis & Rheumatology

Interleukin-6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis

(2013) A. Thiolat et al.   Arthritis & Rheumatology

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

(2012) Eric Meffre   Annals of the New York Academy of Sciences

Hunting for the pathogenesis of rheumatoid arthritis: core-needle biopsy of inguinal lymph nodes as a new research tool

(2012) Maria J H de Hair et al.   ANNALS OF THE RHEUMATIC DISEASES

Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

(2012) Jacques-Eric Gottenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile

(2012) Karin Lundberg et al.   ANNALS OF THE RHEUMATIC DISEASES

The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium

(2012) Silke Frey et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow

(2012) Jie Li et al.   ARTHRITIS AND RHEUMATISM

Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases

(2012) Elisa Corsiero et al.   IMMUNOLOGY LETTERS

Synovium CD20 expression is a potential new predictor of bone erosion progression in very-early arthritis treated by sequential DMARDs monotherapy – A pilot study from the VErA cohort

(2012) Karine Lanfant-Weybel et al.   JOINT BONE SPINE

The complexity of the BAFF TNF-family members: Implications for autoimmunity

(2012) Ayan Lahiri et al.   JOURNAL OF AUTOIMMUNITY

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD23+CD21highCD1dhigh B Cells in Inflamed Lymph Nodes Are a Locally Differentiated Population with Increased Antigen Capture and Activation Potential

(2012) S. Moshkani et al.   JOURNAL OF IMMUNOLOGY

The influence of ACPA status and characteristics on the course of RA

(2012) Annemiek Willemze et al.   Nature Reviews Rheumatology

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological disease-modifying anti-rheumatic drugs

(2012) Serena Bugatti et al.   ARTHRITIS RESEARCH & THERAPY

Assessment of synovitis to predict bone erosions in rheumatoid arthritis

(2012) Serena Bugatti et al.   Therapeutic Advances in Musculoskeletal Disease

Corrections

(2011)   ANNALS OF THE RHEUMATIC DISEASES

Ultrasonographic and MRI characterisation of the palindromic phase of rheumatoid arthritis

(2011) Serena Bugatti et al.   ANNALS OF THE RHEUMATIC DISEASES

Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion

(2011) S. Finzel et al.   ANNALS OF THE RHEUMATIC DISEASES

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

(2011) M. Bombardieri et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

(2011) L. Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

B cell activation biomarkers as predictive factors for the response to rituximab in rheumatoid arthritis: A six-month, national, multicenter, open-label study

(2011) Jérémie Sellam et al.   ARTHRITIS AND RHEUMATISM

Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint

(2011) Cees M. Meeuwisse et al.   ARTHRITIS AND RHEUMATISM

Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis

(2011) Anne Duer-Jensen et al.   ARTHRITIS AND RHEUMATISM

Blood memory B cells are disturbed and predict the response to rituximab in patients with rheumatoid arthritis

(2011) Jérémie Sellam et al.   ARTHRITIS AND RHEUMATISM

The anti-CD20 antibody rituximab reduces the Th17 cell response

(2011) Frank L. van de Veerdonk et al.   ARTHRITIS AND RHEUMATISM

Early treatment in early undifferentiated arthritis

(2011) Ignazio Olivieri et al.   AUTOIMMUNITY REVIEWS

Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF

(2011) Ghada Alsaleh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human T cells induce their own regulation through activation of B cells

(2011) Sébastien Lemoine et al.   JOURNAL OF AUTOIMMUNITY

Synovial Infiltration with CD79a-positive B Cells, But Not Other B Cell Lineage Markers, Correlates with Joint Destruction in Rheumatoid Arthritis

(2011) Y.-Q. MO et al.   JOURNAL OF RHEUMATOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo

(2011) R. A. Sweet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subclinical remodelling of draining lymph node structure in early and established rheumatoid arthritis assessed by power Doppler ultrasonography

(2011) A. Manzo et al.   RHEUMATOLOGY

A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis

(2011) K. Owczarczyk et al.   Science Translational Medicine

CD23+/CD21hi B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice

(2011) Jie Li et al.   ARTHRITIS RESEARCH & THERAPY

Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers

(2011) Serena Bugatti et al.   Current Rheumatology Reports

Elevated number of recently activated T cells in bone marrow of patients with rheumatoid arthritis: a role for interleukin 15?

(2010) E. Kuca-Warnawin et al.   ANNALS OF THE RHEUMATIC DISEASES

Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time?

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

Management of nonresponse to rituximab in rheumatoid arthritis: Predictors and outcome of re-treatment

(2010) E. M. Vital et al.   ARTHRITIS AND RHEUMATISM

V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis

(2010) Tobias Scheel et al.   ARTHRITIS AND RHEUMATISM

Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis

(2010) Laurence Menard et al.   ARTHRITIS AND RHEUMATISM

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Expanded CD23+/CD21hi B Cells in Inflamed Lymph Nodes Are Associated with the Onset of Inflammatory-Erosive Arthritis in TNF-Transgenic Mice and Are Targets of Anti-CD20 Therapy

(2010) J. Li et al.   JOURNAL OF IMMUNOLOGY

Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers

(2010) Thomas Dörner et al.   PHARMACOLOGY & THERAPEUTICS

Proinflammatory T helper type 17 cells are effective B-cell helpers

(2010) M. Mitsdoerffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations on peripheral blood B-cell subpopulations in very early arthritis patients

(2010) R. A. Moura et al.   RHEUMATOLOGY

CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis

(2010) S. Rosengren et al.   RHEUMATOLOGY

Cytokine pattern in very early rheumatoid arthritis favours B-cell activation and survival

(2010) R. A. Moura et al.   RHEUMATOLOGY

Long term treatment of rheumatoid arthritis with rituximab

(2009) Roberto Caporali et al.   AUTOIMMUNITY REVIEWS

New ELISA for B Cell-Activating Factor

(2009) L. Le Pottier et al.   CLINICAL CHEMISTRY

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

(2009) Antonio Manzo et al.   IMMUNOLOGICAL REVIEWS

Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor

(2009) M Margarida Souto-Carneiro et al.   ARTHRITIS RESEARCH & THERAPY

Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort

(2009) Jacques-Eric Gottenberg et al.   ARTHRITIS RESEARCH & THERAPY

Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis

(2009) Toshihiro Nanki et al.   ARTHRITIS RESEARCH & THERAPY

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation

(2008) Y K O Teng et al.   ANNALS OF THE RHEUMATIC DISEASES

Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease

(2008) N Dalbeth et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor   therapy in rheumatoid arthritis

(2008) J D Canete et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-CD20 therapy in patients with rheumatoid arthritis: Predictors of response and B cell subset regeneration after repeated treatment

(2008) Petra Roll et al.   ARTHRITIS AND RHEUMATISM

T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

(2008) Robin A. Herlands et al.   IMMUNITY

Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression

(2007) E A Haavardsholm et al.   ANNALS OF THE RHEUMATIC DISEASES