Chronic Infections: A Possible Scenario for Autophagy and Senescence Cross-Talk

Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging

(2018) Aurélie Le Page et al.   EXPERIMENTAL GERONTOLOGY

Age and immunity: What is “immunosenescence”?

(2018) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

Chaperone-mediated autophagy: Advances from bench to bedside

(2018) Wenming Li et al.   NEUROBIOLOGY OF DISEASE

The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose

(2018) Anke Redeker et al.   Frontiers in Immunology

Analysis of host-pathogen modulators of autophagy during Mycobacterium Tuberculosis infection and therapeutic repercussions

(2017) Arshad Khan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome Maturation and Fusion

(2017) Fulvio Reggiori et al.   JOURNAL OF MOLECULAR BIOLOGY

Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB

(2017) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis

(2017) Polyxeni Kalisperati et al.   Frontiers in Genetics

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Pseudomonastoxin pyocyanin triggers autophagy: Implications for pathoadaptive mutations

(2016) Zhong-Shan Yang et al.   Autophagy

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Structure biology of selective autophagy receptors

(2016) Byeong-Won Kim et al.   BMB Reports

Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option

(2016) María Laura Sbaraglini et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

SalmonellaCo-opts Host Cell Chaperone-mediated Autophagy for Intracellular Growth

(2016) Vikash Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Mesenchymal stromal cells in renal transplantation: opportunities and challenges

(2016) Federica Casiraghi et al.   Nature Reviews Nephrology

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

Cystic fibrosis lung environment and Pseudomonas aeruginosa infection

(2016) Anjali Y. Bhagirath et al.   BMC Pulmonary Medicine

Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment

(2016) Florencia Belén González et al.   PLoS Neglected Tropical Diseases

Pseudomonas aeruginosainfection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches

(2016) Helena Lund-Palau et al.   Expert Review of Respiratory Medicine

Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells

(2015) Ulrik Stervbo et al.   AGE

Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins

(2015) Lina Mouna et al.   Autophagy

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes

(2015) Hae-Ok Byun et al.   BMB Reports

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of CD8+ T-cell cytotoxicity in HIV-1 infection

(2015) Alireza Saeidi et al.   CELLULAR IMMUNOLOGY

Dendritic Cells and Macrophages: Sentinels in the Kidney

(2015) C. K. Weisheit et al.   Clinical Journal of the American Society of Nephrology

Perturbed T Cell IL-7 Receptor Signaling in Chronic Chagas Disease

(2015) M. Cecilia Albareda et al.   JOURNAL OF IMMUNOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine

(2015) Daniela Frasca et al.   VACCINE

Autophagy response: manipulating the mTOR-controlled machinery by amino acids and pathogens

(2014) Claudio Marcelo Fader et al.   AMINO ACIDS

Naive T cells: The crux of cellular immune aging?

(2014) Victor Appay et al.   EXPERIMENTAL GERONTOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

(2014) Izumi Horikawa et al.   Nature Communications

Acute Chagas Disease: New Global Challenges for an Old Neglected Disease

(2014) Daniela V. Andrade et al.   PLoS Neglected Tropical Diseases

Immunosurveillance of senescent cells: the bright side of the senescence program

(2013) Adi Sagiv et al.   BIOGERONTOLOGY

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Selective autophagy

(2013) Steingrim Svenning et al.   Essays in Biochemistry

Killer Cell Lectin-Like Receptor G1 Deficiency Significantly Enhances Survival after Mycobacterium tuberculosis Infection

(2013) Joshua C. Cyktor et al.   INFECTION AND IMMUNITY

Impact of human cytomegalovirus (CMV) infection on immune response to pandemic 2009 H1N1 influenza vaccine in healthy adults

(2013) Anna Wald et al.   JOURNAL OF MEDICAL VIROLOGY

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under Starvation

(2013) Aiko Matsui et al.   PLoS Genetics

Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms

(2013) Maria Eugenia Mansilla Pareja et al.   Frontiers in Cellular and Infection Microbiology

Human T Cell Aging and the Impact of Persistent Viral Infections

(2013) T. Fülöp et al.   Frontiers in Immunology

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy

(2012) Zhen Zhao et al.   DEVELOPMENTAL CELL

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

(2012) Deepa Raju et al.   GASTROENTEROLOGY

Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay

(2012) Patricia Silvia Romano et al.   IUBMB LIFE

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Senescence determines the fate of activated rat pancreatic stellate cells

(2012) Brit Fitzner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sepsis in nonagenarians admitted to Internal Medicine departments: a comparative study of outcomes

(2012) M. Vardi et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

(2012) Evelyna Derhovanessian et al.   VACCINE

Herpes Simplex Virus  34.5 Interferes with Autophagosome Maturation and Antigen Presentation in Dendritic Cells

(2012) P. A. M. Gobeil et al.   mBio

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Lessons from senescence: Chromatin maintenance in non-proliferating cells

(2011) Taranjit Singh Rai et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+ CD45RA+ CD27− T cells: the potential involvement of interleukin-7 in this process

(2011) Valentina Libri et al.   IMMUNOLOGY

Cytotoxic CD4+ T Cell Responses to EBV Contrast with CD8 Responses in Breadth of Lytic Cycle Antigen Choice and in Lytic Cycle Recognition

(2011) H. M. Long et al.   JOURNAL OF IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Early Induction of Autophagy in Human Fibroblasts after Infection with Human Cytomegalovirus or Herpes Simplex Virus 1

(2011) S. McFarlane et al.   JOURNAL OF VIROLOGY

The Human Cytomegalovirus Protein TRS1 Inhibits Autophagy via Its Interaction with Beclin 1

(2011) M. Chaumorcel et al.   JOURNAL OF VIROLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

(2011) Hiroshi Koga et al.   Nature Communications

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Conversion ofHelicobacter pyloriCagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

(2010) Yasuhiro Saito et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preferential infection and depletion ofMycobacterium tuberculosis–specific CD4 T cells after HIV-1 infection

(2010) Christof Geldmacher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases

(2010) Gayani Nadika Pitiyage et al.   JOURNAL OF PATHOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

The autophagic pathway is a key component in the lysosomal dependent entry ofTrypanosoma cruziinto the host cell

(2009) Patricia S. Romano et al.   Autophagy

Effect ofHelicobacter pylori’s vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells

(2009) Mauricio R. Terebiznik et al.   Autophagy

Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: Role for p38 mitogen-activated protein kinase

(2009) Michael Muller et al.   BURNS

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals

(2009) S. Chidrawar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunosenescence: what does it mean to health outcomes in older adults?

(2009) Janet E McElhaney et al.   CURRENT OPINION IN IMMUNOLOGY

Cytomegalovirus and immune senescence: Culprit or innocent bystander?

(2009) Urs Karrer et al.   EXPERIMENTAL GERONTOLOGY

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Chronic Human Infection with Trypanosoma cruzi Drives CD4+ T Cells to Immune Senescence

(2009) M. C. Albareda et al.   JOURNAL OF IMMUNOLOGY

A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people

(2009) Giuseppina Colonna-Romano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

The aging of the immune system

(2009) Daniela Weiskopf et al.   TRANSPLANT INTERNATIONAL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Senescence, Apoptosis or Autophagy?

(2008) José Miguel Vicencio et al.   GERONTOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice

(2008) C. Castellani et al.   Journal of Cystic Fibrosis

Apoptosis: A review of pro-apoptotic and anti-apoptotic pathways and dysregulation in disease

(2008) Mauria A. O'Brien et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY