Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

(2018) Prashant Rajbhandari et al.   CELL

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

(2018) Claudia M. Wunderlich et al.   Nature Communications

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage

(2018) Tahereh Setayesh et al.   EUROPEAN JOURNAL OF NUTRITION

The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet

(2018) Huan Wang et al.   MOLECULES

Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

(2018) Melanie J. Mittenbühler et al.   Molecular Metabolism

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

(2018) Marcus Grohmann et al.   CELL

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

(2017) Trieu-My Van et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice

(2017) Jin-Seon Yook et al.   JOURNAL OF MEDICINAL FOOD

Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice

(2017) Shima Bibi et al.   Obesity

SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma

(2017) L-C Fan et al.   ONCOGENE

Macrophage function in obesity-induced inflammation and insulin resistance

(2017) Mario A. R. Lauterbach et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

(2017) Elaine Xu et al.   Nature Communications

Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet

(2017) et al.   Nutrients

Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

(2017) Mengmeng Jiang et al.   Frontiers in Immunology

Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro

(2017) Jian Wen et al.   Scientific Reports

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

(2017) Rizwan Ahmad et al.   Scientific Reports

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

(2016) Juri Bergmann et al.   HEPATOLOGY

The modern interleukin-1 superfamily: Divergent roles in obesity

(2016) Man K.S. Lee et al.   SEMINARS IN IMMUNOLOGY

Interaction of obesity and inflammatory bowel disease

(2016) Jason W Harper et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

(2016) L Catrysse et al.   Cell Death & Disease

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

(2016) Max Gulhane et al.   Scientific Reports

Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma

(2016) Myoung Sook Han et al.   Cell Reports

Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair

(2016) K Aden et al.   Oncogenesis

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice

(2016) Madeleine Themanns et al.   Scientific Reports

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

(2015) Vangelis Kondylis et al.   CANCER CELL

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

(2015) Lucile Garidou et al.   Cell Metabolism

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

(2015) Michael J. Kraakman et al.   Cell Metabolism

Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study

(2015) Monika Izano et al.   INTERNATIONAL JOURNAL OF CANCER

Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors on Intact Cells

(2015) Isabell Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway

(2015) Zeinab Saadatdoust et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression

(2015) Haiyang Chen et al.   Molecular Cancer

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Versatile functions for IL-6 in metabolism and cancer

(2015) Jan Mauer et al.   TRENDS IN IMMUNOLOGY

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

(2015) M Hatting et al.   Cell Death & Disease

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout

(2014) H Ehlken et al.   CELL DEATH AND DIFFERENTIATION

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer

(2014) Krasimira Aleksandrova et al.   HEPATOLOGY

The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer

(2014) SHU-WEI WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

(2014) Manon D. Schulz et al.   NATURE

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Effects of Calorie Restriction and Diet-Induced Obesity on Murine Colon Carcinogenesis, Growth and Inflammatory Factors, and MicroRNA Expression

(2014) Susan E. Olivo-Marston et al.   PLoS One

T cell-intrinsic role of IL-6 signaling in primary and memory responses

(2014) Simone A Nish et al.   eLife

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model

(2013) F J Cubero et al.   CELL DEATH AND DIFFERENTIATION

Morphological and Inflammatory Changes in Visceral Adipose Tissue During Obesity

(2013) Xavier S. Revelo et al.   ENDOCRINE PATHOLOGY

TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migrationviaNF-κB activation in liver cells

(2013) L. Kastl et al.   FEBS LETTERS

Discovery of novel src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma

(2013) Wei-Tien Tai et al.   HEPATOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

(2013) Georg Schett et al.   NATURE MEDICINE

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling

(2013) Sabine Gruber et al.   Cell Reports

Inflammation and liver tumorigenesis

(2013) Beicheng Sun et al.   Frontiers of Medicine

Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma

(2012) T Kantola et al.   BRITISH JOURNAL OF CANCER

Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma

(2012) Jeong Won Jang et al.   CYTOKINE

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

(2012) J. Hoge et al.   JOURNAL OF IMMUNOLOGY

Prognostic value of circulating cytokines for stage III colon cancer

(2012) Won-Suk Lee et al.   JOURNAL OF SURGICAL RESEARCH

Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung

(2012) O Dienz et al.   Mucosal Immunology

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

(2012) Deborah C. Rubin et al.   Frontiers in Immunology

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Serum Interleukin-6, Insulin, and HOMA-IR in Male Individuals with Colorectal Adenoma

(2011) Y. Sasaki et al.   CLINICAL CANCER RESEARCH

The role of JNK in the development of hepatocellular carcinoma

(2011) Madhumita Das et al.   GENES & DEVELOPMENT

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer

(2011) Zhenhua Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis

(2010) Swaroop Pendyala et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action

(2010) F. Thomas Wunderlich et al.   Cell Metabolism

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Genetic ablation of Tnfα demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis

(2010) Hiroyasu Sakai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity1

(2010) Nirupa Sachithanandan et al.   HEPATOLOGY

Adipose tissue lymphocytes: types and roles

(2010) S. Caspar-Bauguil et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Colorectal cancer

(2010) David Cunningham et al.   LANCET

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice

(2009) K. A. Baltgalvis et al.   Cancer Prevention Research

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT

Serum interleukin-6 levels in colorectal cancer patients—a summary of published results

(2009) Heike Knüpfer et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

(2009) J M Moreno-Navarrete et al.   INTERNATIONAL JOURNAL OF OBESITY

IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens

(2009) W. A. Neveu et al.   JOURNAL OF IMMUNOLOGY

The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

(2009) Ledu Zhou et al.   MEDICAL ONCOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Dietary Induction of Colonic Tumors in a Mouse Model of Sporadic Colon Cancer

(2008) K. Yang et al.   CANCER RESEARCH

Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer

(2008) H. L. Newmark et al.   CARCINOGENESIS

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

(2008) Boryana K. Popivanova et al.   JOURNAL OF CLINICAL INVESTIGATION

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH

Hepatic NF- B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

(2008) F. T. Wunderlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells

(2008) Maria Paula Longhi et al.   PLoS Pathogens