T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
出版年份 2018 全文链接
标题
T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
作者
关键词
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出版物
Frontiers in Immunology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-11-09
DOI
10.3389/fimmu.2018.02569
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions
- (2018) Masao Hashimoto et al. Annual Review of Medicine
- Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
- (2018) Bertram Bengsch et al. IMMUNITY
- T cell senescence and CAR-T cell exhaustion in hematological malignancies
- (2018) Dimitri Kasakovski et al. Journal of Hematology & Oncology
- A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation
- (2018) Ewoud B. Compeer et al. Nature Communications
- Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection
- (2018) Yean K. Yong et al. Frontiers in Immunology
- Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion
- (2018) Muttiah Barathan et al. Cells
- Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection
- (2017) Kevin Man et al. IMMUNITY
- CAR T-cell therapy of solid tumors
- (2017) Carmen S M Yong et al. IMMUNOLOGY AND CELL BIOLOGY
- Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy
- (2017) Cynthia L. Gay et al. JOURNAL OF INFECTIOUS DISEASES
- IRF9 Prevents CD8 + T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection
- (2017) Magdalena Huber et al. JOURNAL OF VIROLOGY
- Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
- (2017) Paola Fisicaro et al. NATURE MEDICINE
- PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways
- (2017) Shengwei Liu et al. Oncotarget
- PD1 signal transduction pathways in T cells
- (2017) Hugo Arasanz et al. Oncotarget
- Persistent infection due to a small-colony variant of Burkholderia pseudomallei leads to PD-1 upregulation on circulating immune cells and mononuclear infiltration in viscera of experimental BALB/c mice
- (2017) Jia-Xiang See et al. PLoS Neglected Tropical Diseases
- Mitochondrial Control and Guidance of Cellular Activities of T Cells
- (2017) Tung Chao et al. Frontiers in Immunology
- Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease Progression
- (2017) Fareed Ahmad et al. Frontiers in Immunology
- Unlocking the epigenetic code of T cell exhaustion
- (2017) Jiazhu Wu et al. Translational Cancer Research
- Genetic footprints of T cell exhaustion
- (2017) Marcus Buggert et al. Translational Cancer Research
- The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond
- (2016) Tamara Suprunenko et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Peripheral loss of CD8+CD161++TCRVα7·2+mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients
- (2016) Muttiah Barathan et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Hepatitis C virus (HCV) RNA profiles among chronic HIV/HCV-coinfected individuals in ESPRIT; spontaneous HCV RNA clearance observed in nine individuals
- (2016) D Grint et al. HIV MEDICINE
- Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection
- (2016) James P. Scott-Browne et al. IMMUNITY
- Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
- (2016) Bertram Bengsch et al. IMMUNITY
- Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
- (2016) Leonid Cherkassky et al. JOURNAL OF CLINICAL INVESTIGATION
- Metabolic regulation of immune responses: therapeutic opportunities
- (2016) Nadine Assmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting type I interferon–mediated activation restores immune function in chronic HIV infection
- (2016) Anjie Zhen et al. JOURNAL OF CLINICAL INVESTIGATION
- Blimp-1–mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis
- (2016) SuJin Hwang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion
- (2016) Eunseon Ahn et al. JOURNAL OF VIROLOGY
- Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
- (2016) Se Jin Im et al. NATURE
- The epigenetic landscape of T cell exhaustion
- (2016) D. R. Sen et al. SCIENCE
- Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
- (2016) K. E. Pauken et al. SCIENCE
- Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis
- (2016) Madison Black et al. Oncotarget
- Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host
- (2016) Anna Schurich et al. Cell Reports
- Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes
- (2015) Muttiah Barathan et al. APOPTOSIS
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Manipulating IL-10 signalling blockade for better immunotherapy
- (2015) Guoying Ni et al. CELLULAR IMMUNOLOGY
- The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
- (2015) Gustavo J. Martinez et al. IMMUNITY
- Interleukin-17 and innate immunity in infections and chronic inflammation
- (2015) Natasa Isailovic et al. JOURNAL OF AUTOIMMUNITY
- IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques
- (2015) A M Ortiz et al. Mucosal Immunology
- Attrition of TCR Vα7.2+ CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression
- (2015) Alireza Saeidi et al. PLoS One
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
- (2015) Kathrin Schumann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration
- (2015) I. Okoye et al. SCIENCE
- Adoptive Cell Therapy—Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors
- (2015) Steven A. Feldman et al. SEMINARS IN ONCOLOGY
- T cell exhaustion during persistent viral infections
- (2015) Shannon M. Kahan et al. VIROLOGY
- Immune Response in Hepatitis B Virus Infection
- (2015) Anthony Tan et al. Cold Spring Harbor Perspectives in Medicine
- The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
- (2014) Matthew M. Staron et al. IMMUNITY
- Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression
- (2014) Tom L. Stephen et al. IMMUNITY
- Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection
- (2014) Alison Crawford et al. IMMUNITY
- Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
- (2014) Pablo Penaloza-MacMaster et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection
- (2014) Fuqin Zhang et al. MOLECULAR THERAPY
- Interleukin-21: a double-edged sword with therapeutic potential
- (2014) Rosanne Spolski et al. NATURE REVIEWS DRUG DISCOVERY
- The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection
- (2014) Anna Schurich et al. Frontiers in Immunology
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections
- (2013) Cherie T. Ng et al. Cell Host & Microbe
- T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice
- (2013) Karin Krebs et al. GASTROENTEROLOGY
- Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
- (2013) Juanjuan Zhao et al. HEPATOLOGY
- Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
- (2013) Laura A. Sena et al. IMMUNITY
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- Role of regulatory T cells during virus infection
- (2013) Tamara Veiga-Parga et al. IMMUNOLOGICAL REVIEWS
- Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?
- (2013) Celeste Goh et al. IMMUNOLOGICAL REVIEWS
- PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
- (2013) Bernd H. Zinselmeyer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells
- (2013) B. Youngblood et al. JOURNAL OF IMMUNOLOGY
- Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans
- (2013) Douglas V. Dolfi et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Differential Impact of PD-1 and/or Interleukin-10 Blockade on HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Functions
- (2013) F. Porichis et al. JOURNAL OF VIROLOGY
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection
- (2013) David Gardiner et al. PLoS One
- Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
- (2013) M. J. Fuller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection
- (2013) T. A. W. Holderried et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular signatures of T-cell inhibition in HIV-1 infection
- (2013) Marie Larsson et al. Retrovirology
- Tolerance and exhaustion: defining mechanisms of T cell dysfunction
- (2013) Andrea Schietinger et al. TRENDS IN IMMUNOLOGY
- IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
- (2013) Iwana Schmitz et al. PLoS Pathogens
- The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells
- (2013) Anna Schurich et al. PLoS Pathogens
- Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
- (2013) Liza B John et al. OncoImmunology
- Regulation of Immune Responses by mTOR
- (2012) Jonathan D. Powell et al. Annual Review of Immunology
- Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
- (2012) Travis A. Doering et al. IMMUNITY
- PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
- (2012) Ravi Dyavar Shetty et al. JOURNAL OF CLINICAL INVESTIGATION
- Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
- (2012) Tadashi Yokosuka et al. JOURNAL OF EXPERIMENTAL MEDICINE
- In Vivo Blockade of the PD-1 Receptor Suppresses HIV-1 Viral Loads and Improves CD4+ T Cell Levels in Humanized Mice
- (2012) B. E. Palmer et al. JOURNAL OF IMMUNOLOGY
- Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes
- (2012) M. A. Paley et al. JOURNAL OF LEUKOCYTE BIOLOGY
- IL-10 Mediated Regulation of Liver Inflammation during Acute Murine Cytomegalovirus Infection
- (2012) Pamela J. Gaddi et al. PLoS One
- Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection
- (2012) M. A. Paley et al. SCIENCE
- Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation
- (2012) N. Patsoukis et al. Science Signaling
- Evolving role of 2B4/CD244 in T and NK cell responses during virus infection
- (2012) Stephen N. Waggoner et al. Frontiers in Immunology
- PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+T cells
- (2011) Katarzyna Karwacz et al. EMBO Molecular Medicine
- Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells
- (2011) Ben Youngblood et al. IMMUNITY
- Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load
- (2011) Erin E. West et al. IMMUNITY
- Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
- (2011) Charlly Kao et al. NATURE IMMUNOLOGY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation
- (2010) Thomas C. Wirth et al. IMMUNITY
- The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
- (2010) Rajesh R. Rao et al. IMMUNITY
- Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1
- (2010) Xinyuan Zhou et al. IMMUNITY
- T-cell exhaustion: characteristics, causes and conversion
- (2010) John S. Yi et al. IMMUNOLOGY
- Pronounced Virus-Dependent Activation Drives Exhaustion but Sustains IFN- Transcript Levels
- (2010) K. J. Mackerness et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche
- (2010) A. Banerjee et al. JOURNAL OF IMMUNOLOGY
- Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
- (2010) Michael Quigley et al. NATURE MEDICINE
- Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery
- (2010) S. Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
- (2009) M. A. Brockman et al. BLOOD
- A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection
- (2009) Haina Shin et al. IMMUNITY
- PD-1 signaling in primary T cells
- (2009) James L. Riley IMMUNOLOGICAL REVIEWS
- PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention
- (2009) Daniel E. Kaufmann et al. JOURNAL OF IMMUNOLOGY
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism
- (2009) Erika L. Pearce et al. NATURE
- IL-21 Is Required to Control Chronic Viral Infection
- (2009) H. Elsaesser et al. SCIENCE
- IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection
- (2009) A. Frohlich et al. SCIENCE
- The role of secondary lymphatic tissue in immune deficiency of HIV infection
- (2008) Timothy Schacker AIDS
- Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization
- (2008) Nobuhiro Nakamoto et al. GASTROENTEROLOGY
- Enhancing SIV-specific immunity in vivo by PD-1 blockade
- (2008) Vijayakumar Velu et al. NATURE
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
- IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
- (2008) D. G. Brooks et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective expansion of a subset of exhausted CD8 T cells by PD-L1 blockade
- (2008) S. D. Blackburn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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