Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

Generating diversity: transcriptional regulation of effector and memory CD8+T-cell differentiation

(2015) Rachel L. Rutishauser et al.   IMMUNOLOGICAL REVIEWS

Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors

(2012) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients

(2011) Victor Appay et al.   AIDS

Protective Capacity of Memory CD8+ T Cells Is Dictated by Antigen Exposure History and Nature of the Infection

(2011) Jeffrey C. Nolz et al.   IMMUNITY

Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade

(2011) Sian M. Henson et al.   IMMUNOLOGY

Functional CD8 T Cell Memory Responding to Persistent Latent Infection Is Maintained for Life

(2011) A. Lang et al.   JOURNAL OF IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Influenza-Specific T Cells from Older People Are Enriched in the Late Effector Subset and Their Presence Inversely Correlates with Vaccine Response

(2011) Lisa E. Wagar et al.   PLoS One

Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans

(2011) Xin Zhou et al.   VACCINE

Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway

(2010) Celine S. Lages et al.   AGING CELL

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

(2010) C. S. Hinrichs et al.   BLOOD

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

(2010) Thomas C. Wirth et al.   IMMUNITY

Cell-Intrinsic Defects in the Proliferative Response of Antiviral Memory CD8 T Cells in Aged Mice upon Secondary Infection

(2010) V. Decman et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool

(2010) P. J. E. J. van de Berg et al.   JOURNAL OF IMMUNOLOGY

T Cell-Mediated Protection against Lethal 2009 Pandemic H1N1 Influenza Virus Infection in a Mouse Model

(2010) H. Guo et al.   JOURNAL OF VIROLOGY

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

KLRG1—more than a marker for T cell senescence

(2009) Sian M. Henson et al.   AGE

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

Immunosenescence: what does it mean to health outcomes in older adults?

(2009) Janet E McElhaney et al.   CURRENT OPINION IN IMMUNOLOGY

Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection

(2009) C. Petrovas et al.   JOURNAL OF IMMUNOLOGY

Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion

(2009) C. M. Bucks et al.   JOURNAL OF IMMUNOLOGY

CD57+ T lymphocytes and functional immune deficiency

(2009) Daniele Focosi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

(2009) Janet E. McElhaney et al.   VACCINE

Memory CD8 T-cell compartment grows in size with immunological experience

(2008) Vaiva Vezys et al.   NATURE

CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator

(2008) Guifang Cai et al.   NATURE IMMUNOLOGY

Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties

(2008) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

(2008) Sven Koch et al.   Immunity & Ageing