Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

(2013) Anne-Marie L. Winther et al.   NATURE

Protein-Protein Interactions in Calcium Transport Regulation Probed by Saturation Transfer Electron Paramagnetic Resonance

(2012) Zachary M. James et al.   BIOPHYSICAL JOURNAL

Distinctive Features of Catalytic and Transport Mechanisms in Mammalian Sarco-endoplasmic Reticulum Ca2+ATPase (SERCA) and Cu+(ATP7A/B) ATPases

(2012) David Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPaseE2State Remains Functional

(2011) Gianluca Bartolommei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholamban Binds with Differential Affinity to Calcium Pump Conformers

(2011) Philip Bidwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity

(2011) Matteo Alemanni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca2+-ATPase

(2011) Martin Gustavsson et al.   JOURNAL OF MOLECULAR BIOLOGY

ATP dependent charge movement in ATP7B Cu+-ATPase is demonstrated by pre-steady state electrical measurements

(2010) Francesco Tadini-Buoninsegni et al.   FEBS LETTERS

Selectivity of Digitalis Glycosides for Isoforms of Human Na,K-ATPase

(2010) Adriana Katz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: Results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-HF) trial

(2009) Sanjiv J. Shah et al.   AMERICAN HEART JOURNAL

Charge transfer in P-type ATPases investigated on planar membranes

(2008) Francesco Tadini-Buoninsegni et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Modulation of Sarcoplasmic Reticulum Function by PST2744 [Istaroxime; (E,Z)-3-((2-Aminoethoxy)imino) Androstane-6,17-dione Hydrochloride)] in a Pressure-Overload Heart Failure Model

(2008) M. Rocchetti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent

(2008) Mihai Gheorghiade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure

(2008) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of High-Affinity Inhibitors on Partial Reactions, Charge Movements, and Conformational States of the Ca2+ Transport ATPase (Sarco-Endoplasmic Reticulum Ca2+ ATPase)

(2008) F. Tadini-Buoninsegni et al.   MOLECULAR PHARMACOLOGY