Nitric Oxide Synthases in Heart Failure

Arginase II inhibition prevents nitrate tolerance

(2012) SML Khong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuronal nitric oxide synthase is up-regulated by angiotensin II and attenuates NADPH oxidase activity and facilitates relaxation in murine left ventricular myocytes

(2012) Chun Zi Jin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

(2012) Oleksandra Prysyazhna et al.   NATURE MEDICINE

Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction

(2011) Takayuki Shimazu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

(2011) S Chandra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II

(2011) Neeru M. Sharma et al.   CARDIOVASCULAR RESEARCH

Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice

(2011) Wai San Cheang et al.   CARDIOVASCULAR RESEARCH

Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis

(2011) Andrey Kazakov et al.   CARDIOVASCULAR RESEARCH

Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation

(2011) Svetlana N. Reilly et al.   CIRCULATION

Pressure-Overload–Induced Subcellular Relocalization/Oxidation of Soluble Guanylyl Cyclase in the Heart Modulates Enzyme Stimulation

(2011) Emily J. Tsai et al.   CIRCULATION RESEARCH

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

(2011) Matthew Whiteman et al.   CLINICAL SCIENCE

Effects of the long-term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction: results of the ELANDD study

(2011) Viviane M. Conraads et al.   EUROPEAN JOURNAL OF HEART FAILURE

Betulinic acid ameliorates endothelium-dependent relaxation in l-NAME-induced hypertensive rats by reducing oxidative stress

(2011) Jia-Yin Fu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses

(2011) Danielle Duma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats

(2011) Siddhartha R. Bhatt et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reversible and irreversible protein glutathionylation: biological and clinical aspects

(2011) Arthur JL Cooper et al.   Expert Opinion on Drug Metabolism & Toxicology

Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production

(2011) Saptarshi Kar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

(2011) Mark J. Crabtree et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation byS-Nitrosylation of Protein Post-translational Modification

(2011) Douglas T. Hess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling

(2011) Chun-An Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin

(2011) An L. Moens et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure

(2011) An L. Moens et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Beta3-Adrenoreceptor Stimulation Ameliorates Myocardial Ischemia-Reperfusion Injury Via Endothelial Nitric Oxide Synthase and Neuronal Nitric Oxide Synthase Activation

(2011) Juan P. Aragón et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nebivolol Exerts Beneficial Effects on Endothelial Function, Early Endothelial Progenitor Cells, Myocardial Neovascularization, and Left Ventricular Dysfunction Early After Myocardial Infarction Beyond Conventional β1-Blockade

(2011) Sajoscha A. Sorrentino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac-Specific Overexpression of Caveolin-3 Attenuates Cardiac Hypertrophy and Increases Natriuretic Peptide Expression and Signaling

(2011) Yousuke T. Horikawa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocardial Redox State Predicts In-Hospital Clinical Outcome After Cardiac Surgery

(2011) Charalambos Antoniades et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis

(2011) J. L. Sartoretto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preconditioning by Phosphodiesterase-5 Inhibition Improves Therapeutic Efficacy of Adipose-Derived Stem Cells Following Myocardial Infarction in Mice

(2011) Nicholas N. Hoke et al.   STEM CELLS

Hydrogen Sulfide Increases Nitric Oxide Production from Endothelial Cells by an Akt-Dependent Mechanism

(2011) Benjamin L. Predmore et al.   Frontiers in Physiology

PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation

(2010) Dong I. Lee et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

(2010) Teddy Bagnost et al.   CARDIOVASCULAR RESEARCH

Conditional Overexpression of Neuronal Nitric Oxide Synthase Is Cardioprotective in Ischemia/Reperfusion

(2010) Natalie Burkard et al.   CIRCULATION

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

(2010) Gad A. Silberman et al.   CIRCULATION

Simultaneous Measurement of Protein Oxidation and S -Nitrosylation During Preconditioning and Ischemia/Reperfusion Injury With Resin-Assisted Capture

(2010) Mark J. Kohr et al.   CIRCULATION RESEARCH

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature

(2010) Marlieke Visser et al.   EUROPEAN JOURNAL OF HEART FAILURE

Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study

(2010) H. A. Ghofrani et al.   EUROPEAN RESPIRATORY JOURNAL

Left Ventricular Dysfunction in Murine Models of Heart Failure and in Failing Human Heart is Associated With a Selective Decrease in the Expression of Caveolin-3

(2010) Ellina Cheskis Feiner et al.   JOURNAL OF CARDIAC FAILURE

Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle

(2010) Justin M. Percival et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

(2010) N. Xia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptorS-nitrosylation

(2010) Honglan Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endothelial progenitor cells—an evolving story

(2010) Jeremy D. Pearson   MICROVASCULAR RESEARCH

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability

(2009) Ling Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Role of Nitric Oxide in Myocardial Repair and Remodeling

(2009) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

(2009) C. Jung et al.   CARDIOVASCULAR RESEARCH

Neuronal Nitric Oxide Synthase Protects Against Myocardial Infarction-Induced Ventricular Arrhythmia and Mortality in Mice

(2009) Dylan E. Burger et al.   CIRCULATION

Effects of Neuronal Nitric Oxide Synthase on Human Coronary Artery Diameter and Blood Flow In Vivo

(2009) Michael Seddon et al.   CIRCULATION

Genetic Variations in Nitric Oxide Synthase 1 Adaptor Protein Are Associated With Sudden Cardiac Death in US White Community-Based Populations

(2009) W.H. Linda Kao et al.   CIRCULATION

Nitric Oxide Increases Cardiac I K1 by Nitrosylation of Cysteine 76 of Kir2.1 Channels

(2009) Ricardo Gómez et al.   CIRCULATION RESEARCH

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis

(2009) C. Antoniades et al.   EUROPEAN HEART JOURNAL

Caveolinopathies: from the biology of caveolin-3 to human diseases

(2009) Elisabetta Gazzerro et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Role of xanthine oxidoreductase in cardiac nitroso-redox imbalance

(2009) Konstantinos Tziomalos   Frontiers in Bioscience-Landmark

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

(2009) Jae Hyung Kim et al.   JOURNAL OF APPLIED PHYSIOLOGY

Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells

(2009) Toru Sugiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes

(2009) Honglan Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dihydrofolate reductase and biopterin recycling in cardiovascular disease

(2009) Mark J. Crabtree et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON

(2009) Farideh Beigi et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Endogenous S-nitrosothiols protect against myocardial injury

(2009) B. Lima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous Myocardial Infarction and Nitric Oxide Synthase

(2009) Masato Tsutsui et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Protein S-nitrosylation in health and disease: a current perspective

(2009) Matthew W. Foster et al.   TRENDS IN MOLECULAR MEDICINE

Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban

(2008) Honglan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis

(2008) Krisztian Stadler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

(2008) An L. Moens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes

(2008) Irina A. Ionova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial nitric oxide synthase decreases β-adrenergic responsiveness via inhibition of the L-type Ca2+ current

(2008) Honglan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction

(2008) Jun Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase

(2008) Jian Sun et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1)

(2008) R. Gomez et al.   CARDIOVASCULAR RESEARCH

Different Pharmacological Properties of Two Enantiomers in a Unique β-Blocker, Nebivolol

(2008) Louis J. Ignarro   Cardiovascular Therapeutics

Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition

(2008) Matthew B. West et al.   CIRCULATION

Spontaneous Myocardial Infarction in Mice Lacking All Nitric Oxide Synthase Isoforms

(2008) Sei Nakata et al.   CIRCULATION

Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo

(2008) Michael D. Seddon et al.   CIRCULATION

Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin

(2008) An L. Moens et al.   CIRCULATION

Neuromodulators of peripheral cardiac sympatho-vagal balance

(2008) Neil Herring et al.   EXPERIMENTAL PHYSIOLOGY

Resveratrol stimulates nitric oxide production by increasing estrogen receptor α-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells

(2008) Carolyn M. Klinge et al.   FASEB JOURNAL

Arginase and vascular aging

(2008) Lakshmi Santhanam et al.   JOURNAL OF APPLIED PHYSIOLOGY

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

(2008) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme

(2008) Chun-An Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of the Soluble Guanylate Cyclase Activator Cinaciguat (BAY 58-2667) in Healthy Male Volunteers

(2008) Reiner Frey et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling

(2008) P. Wohlfart et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Impact of Oxypurinol in Patients With Symptomatic Heart Failure

(2008) Joshua M. Hare et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro

(2008) Monica Traverso et al.   LABORATORY INVESTIGATION

S-Nitrosylation of β-Arrestin Regulates β-Adrenergic Receptor Trafficking

(2008) Kentaro Ozawa et al.   MOLECULAR CELL

Sarcolemma-localized nNOS is required to maintain activity after mild exercise

(2008) Yvonne M. Kobayashi et al.   NATURE

Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: Lack of evidence for a role in the bioactivation of nitroglycerin

(2008) Alexander Kollau et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart

(2008) K.-C. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

(2008) K. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac capsaicin-sensitive sensory nerves regulate myocardial relaxation viaS-nitrosylation of SERCA: role of peroxynitrite

(2007) P Bencsik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reduced Phospholamban Phosphorylation Is Associated With Impaired Relaxation in Left Ventricular Myocytes From Neuronal NO Synthase–Deficient Mice

(2007) Yin Hua Zhang et al.   CIRCULATION RESEARCH