Tetrahydrobiopterin in Cardiovascular Health and Disease

Vascular Function During Prolonged Progression and Regression of Atherosclerosis in Mice

(2013) Jordan D. Miller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages

(2013) Suzumi M. Tokuoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tetrahydrobiopterin: biochemistry and pathophysiology

(2013) Ernst R. Werner et al.   BIOCHEMICAL JOURNAL

Alkylglycerol monooxygenase

(2013) Katrin Watschinger et al.   IUBMB LIFE

Tetrahydrobiopterin Supplementation Enhances Carotid Artery Compliance in Healthy Older Men: A Pilot Study

(2012) Gary L. Pierce et al.   AMERICAN JOURNAL OF HYPERTENSION

Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension

(2012) Ji Youn Youn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

(2012) David Adlam et al.   CARDIOVASCULAR RESEARCH

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

(2012) Colin Cunnington et al.   CIRCULATION

Cardiomyocyte GTP Cyclohydrolase 1 and Tetrahydrobiopterin Increase NOS1 Activity and Accelerate Myocardial Relaxation

(2012) Ricardo Carnicer et al.   CIRCULATION RESEARCH

Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock*

(2012) Xinrong He et al.   CRITICAL CARE MEDICINE

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification

(2012) Gillian Douglas et al.   EUROPEAN HEART JOURNAL

Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction

(2012) Yin Liu et al.   EUROPEAN HEART JOURNAL

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages

(2012) Geethanjali Pickert et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of Endothelial Nitric-oxide Synthase (NOS)S-Glutathionylation by Neuronal NOS

(2012) Winifred O. Idigo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of tetrahydrobiopterin and exercise training on endothelium-dependent vasorelaxation in SHR

(2012) François Guerrero et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE−/− Mice

(2012) Padmapriya Ponnuswamy et al.   PLoS One

Tetrahydrobiopterin Deficiency and Nitric Oxide Synthase Uncoupling Contribute to Atherosclerosis Induced by Disturbed Flow

(2011) Li Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Simvastatin Ameliorates Angiotensin II-Induced Endothelial Dysfunction Through Restoration of Rho-BH4-eNOS-NO Pathway

(2011) Zheng Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia

(2011) Zhi-Dong Ge et al.   CARDIOVASCULAR RESEARCH

Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation

(2011) Svetlana N. Reilly et al.   CIRCULATION

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

(2011) Charalambos Antoniades et al.   CIRCULATION

Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis

(2011) Charalambos Antoniades et al.   CIRCULATION

Tetrahydrobiopterin Restores Diastolic Function and Attenuates Superoxide Production in Ovariectomized mRen2.Lewis Rats

(2011) Jewell A. Jessup et al.   ENDOCRINOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse

(2011) Jaques Belik et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neopterin and Atherosclerotic Plaque Instability in Coronary and Carotid Arteries

(2011) Kenichi Sugioka et al.   Journal of Atherosclerosis and Thrombosis

Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling

(2011) Chun-An Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure

(2011) An L. Moens et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential role of monocyte subsets in atherosclerosis

(2011) Mihail Hristov et al.   THROMBOSIS AND HAEMOSTASIS

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

(2010) Kyu-Tae Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

RGS19 enhances cell proliferation through its C-terminal PDZ motif

(2010) Prudence H. Tso et al.   CELLULAR SIGNALLING

Cardiovascular Effects of Exercise Training

(2010) Stephan Gielen et al.   CIRCULATION

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

(2010) Gad A. Silberman et al.   CIRCULATION

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

(2010) Tim S. Schmidt et al.   CLINICAL SCIENCE

Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications

(2010) Eileen McNeill et al.   CLINICAL SCIENCE

Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats

(2010) Katsuhiko Noguchi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Safety of sapropterin dihydrochloride (6r–bh4) in patients with pulmonary hypertension

(2010) Ivan M. Robbins et al.   EXPERIMENTAL LUNG RESEARCH

GTP Cyclohydrolase I/BH4 Pathway Protects EPCs via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive Hypertension

(2010) He-Hui Xie et al.   HYPERTENSION

Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart

(2010) Toru Okazaki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

(2010) N. Xia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NO Inhibits Hyperoxia-Induced NF-κB Activation in Neonatal Pulmonary Microvascular Endothelial Cells

(2010) Clyde J Wright et al.   PEDIATRIC RESEARCH

Tetrahydrobiopterin Is Present in High Quantity in Human Milk and Has a Vasorelaxing Effect on Newborn Rat Mesenteric Arteries

(2010) Angela Weinmann et al.   PEDIATRIC RESEARCH

Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes

(2010) K. Watschinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress and Compartment of Gene Expression Determine Proatherosclerotic Effects of Inducible Nitric Oxide Synthase

(2009) Padmapriya Ponnuswamy et al.   AMERICAN JOURNAL OF PATHOLOGY

Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability

(2009) Ling Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

eNOS uncoupling and endothelial dysfunction in aged vessels

(2009) Yang-Ming Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain

(2009) Jeannette Vásquez-Vivar et al.   ANNALS OF NEUROLOGY

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma Tetrahydrobiopterin/Dihydrobiopterin Ratio

(2009) Masafumi Takeda et al.   CIRCULATION JOURNAL

GTP Cyclohydrolase I Phosphorylation and Interaction With GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide

(2009) Li Li et al.   CIRCULATION RESEARCH

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells

(2009) Toru Sugiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

(2009) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic scavenging of peroxynitrite by catalase

(2009) Lidia Gebicka et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity

(2009) Ling Gao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles

(2009) Amy L. Sindler et al.   JOURNAL OF PHYSIOLOGY-LONDON

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2009)   LANCET

Reduced ischemia/reperfusion injury via glutathione-initiated nitric oxide-releasing dendrimers

(2009) Timothy A. Johnson et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels

(2009) Chang-Kwon Lee et al.   PROTEOMICS

Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes

(2008) Irina A. Ionova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS

(2008) Mark J. Crabtree et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction

(2008) Jun Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

CCR2-Mediated Antiinflammatory Effects of Endothelial Tetrahydrobiopterin Inhibit Vascular Injury-Induced Accelerated Atherosclerosis

(2008) Z. A. Ali et al.   CIRCULATION

Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo

(2008) Michael D. Seddon et al.   CIRCULATION

Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin

(2008) An L. Moens et al.   CIRCULATION

Beneficial Effects of Exogenous Tetrahydrobiopterin on Left Ventricular Remodeling After Myocardial Infarction in Rats

(2008) Tomoya Masano et al.   CIRCULATION JOURNAL

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype

(2008) Irmgard Tegeder et al.   EUROPEAN JOURNAL OF PAIN

AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

(2008) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

(2008) Shuangxi Wang et al.   HYPERTENSION

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

(2008) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrahydrobiopterin: a novel antihypertensive therapy

(2008) M Porkert et al.   JOURNAL OF HUMAN HYPERTENSION

GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease

(2008) Charalambos Antoniades et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

(2008) A DOEHRING et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy

(2008) M. Satoh et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Disruption of the endothelial nitric oxide synthase gene affects ovulation, fertilization and early embryo survival in a knockout mouse model

(2008) Pilar Pallares et al.   REPRODUCTION

Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus

(2007) Philip Wenzel et al.   ATHEROSCLEROSIS

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells

(2007) Shunichi Shimizu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY