Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

(2016) Jeff A. Zablocki et al.   JOURNAL OF MEDICINAL CHEMISTRY

The link between abnormal calcium handling and electrical instability in acquired long QT syndrome – Does calcium precipitate arrhythmic storms?

(2016) Jan Němec et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In VivoCLINICAL PERSPECTIVE

(2015) Patric Glynn et al.   CIRCULATION

Intracellular Calcium Attenuates Late Current Conducted by Mutant Human Cardiac Sodium Channels

(2015) Franck Potet et al.   Circulation-Arrhythmia and Electrophysiology

Heterogeneous distribution of INa-L determines interregional differences in rate adaptation of repolarization

(2015) Datun Qi et al.   HEART RHYTHM

Regulation of Ca2+ transient by PP2A in normal and failing heart

(2015) Ming Lei et al.   Frontiers in Physiology

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

(2014) Caimei Zhang et al.   CIRCULATION

Atrial Remodeling and Atrial Fibrillation

(2014) Stanley Nattel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca 2+ Regulation by Distinct Mechanisms

(2014) Guo Yin et al.   Journal of the American Heart Association

SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope

(2013) Markus B Sikkel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Late Sodium Current by Mexiletine

(2013) Yuanfeng Gao et al.   Circulation-Arrhythmia and Electrophysiology

Inhibitors of arachidonate-regulated calcium channel signaling suppress triggered activity induced by the late sodium current

(2013) Paul Wolkowicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Abnormal Ca2+ homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification

(2013) Yanmin Zhang et al.   Frontiers in Physiology

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Stretch Current-Induced Abnormal Impulses in CaMKIIδ Knockout Mouse Ventricular Myocytes

(2012) DONGWU LAI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Sophocarpine Attenuates the Na+-dependent Ca2+ Overload Induced by Anemonia Sulcata Toxin—Increased Late Sodium Current in Rabbit Ventricular Myocytes

(2012) Shuo Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inherited calcium channelopathies in the pathophysiology of arrhythmias

(2012) Luigi Venetucci et al.   Nature Reviews Cardiology

Resveratrol Attenuates the Na+-Dependent Intracellular Ca2+ Overload by Inhibiting H2O2-Induced Increase in Late Sodium Current in Ventricular Myocytes

(2012) Chunping Qian et al.   PLoS One

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice

(2011) Lina Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes

(2011) Jihua Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of I Kr Inhibition on Ventricular Repolarization

(2011) Lin Wu et al.   CIRCULATION

Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na+ current in the heart

(2009) Lin Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca 2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

(2008) Fabrice Prunier et al.   CIRCULATION

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine

(2008) Lin Wu et al.   HEART RHYTHM

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS