Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption

Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid CancerIn VitroandIn Vivo

(2018) Shilpa Thakur et al.   CLINICAL CANCER RESEARCH

Metformin in cancer

(2018) Ritwika Mallik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

(2017) Sun Hye Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

(2017) Hui Wang et al.   Oncotarget

Results from 11C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

(2017) Ane B. Iversen et al.   Scientific Reports

Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia

(2016) Johann Matschke et al.   ANTIOXIDANTS & REDOX SIGNALING

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

(2016) Stepana Boukalova et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth

(2016) D Obinata et al.   ONCOGENE

Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps

(2016) LaShanale Wallace et al.   TUMOR BIOLOGY

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

(2016) Thomas M. Ashton et al.   Nature Communications

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma

(2016) Tiziana Petrachi et al.   Oncotarget

Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

(2016) Juliana Velez et al.   Oncotarget

Repurposing metformin for cancer treatment: current clinical studies

(2016) Young Kwang Chae et al.   Oncotarget

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

(2016) Paloma Navarro et al.   Cell Reports

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Radiosensitization of metformin in pancreatic cancer cells via abrogating the G2 checkpoint and inhibiting DNA damage repair

(2015) Zheng Wang et al.   CANCER LETTERS

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers

(2015) M. Momcilovic et al.   CANCER RESEARCH

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand

(2015) A. Lin et al.   CLINICAL CANCER RESEARCH

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs

(2015) CHIA-CHI HSU et al.   ONCOLOGY REPORTS

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

(2015) Xinke Zhou et al.   Oncotarget

Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells

(2015) Zhao Liu et al.   PLoS One

Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy

(2015) Yimin Zhang et al.   Oncotarget

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

(2014) Allison B. Haugrud et al.   BREAST CANCER RESEARCH AND TREATMENT

Serine Deprivation Enhances Antineoplastic Activity of Biguanides

(2014) S.-P. Gravel et al.   CANCER RESEARCH

Synergistic Effect of Phenformin in Non-Small Cell Lung Cancer (NSCLC) Ionizing Radiation Treatment

(2014) Jia Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome

(2014) Andrus Kaldma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

(2014) Stefania Orecchioni et al.   INTERNATIONAL JOURNAL OF CANCER

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Synergistic Anti-Cancer Effect of Phenformin and Oxamate

(2014) W. Keith Miskimins et al.   PLoS One

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

(2014) L Chang et al.   Cell Death & Disease

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

(2013) Y Storozhuk et al.   BRITISH JOURNAL OF CANCER

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

(2013) V. E. Zannella et al.   CLINICAL CANCER RESEARCH

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatocytes Determine the Hypoxic Microenvironment and Radiosensitivity of Colorectal Cancer Cells Through Production of Nitric Oxide That Targets Mitochondrial Respiration

(2012) Heng Jiang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Diabetes, Metformin, and Breast Cancer: Lilac Time?

(2012) Pamela J. Goodwin et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells

(2012) Chang W. Song et al.   Scientific Reports

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

(2011) Eric D. Segal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors

(2011) C. Diepart et al.   CANCER RESEARCH

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond

(2010) Lev M Berstein   Future Oncology

Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status

(2010) Nagata   INTERNATIONAL JOURNAL OF ONCOLOGY

Activated Macrophages as a Novel Determinant of Tumor Cell Radioresponse: The Role of Nitric Oxide–Mediated Inhibition of Cellular Respiration and Oxygen Sparing

(2010) Heng Jiang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Metformin and the intestine

(2008) C. J. Bailey et al.   DIABETOLOGIA

Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer

(2008) S. Yokoo et al.   DRUG METABOLISM AND DISPOSITION

Dithiothreitol abrogates the effect of arsenic trioxide on normal rat liver mitochondria and human hepatocellular carcinoma cells

(2007) Manash K. Paul et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY