Review
Oncology
Leenu Reinsalu, Marju Puurand, Vladimir Chekulayev, Sten Miller, Igor Shevchuk, Kersti Tepp, Egle Rebane-Klemm, Natalja Timohhina, Anton Terasmaa, Tuuli Kaambre
Summary: Metabolic plasticity is the ability of cells to adjust metabolism to environmental changes. Cancer cells exhibit increased metabolic plasticity, allowing them to have a survival advantage and higher proliferative capacity. This enhanced plasticity is characterized by changes in adenine nucleotide transport, impaired regulation of VDAC and reprogrammed energy transfer circuits like AK and CK pathways.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alexander Bernhard Rister, Thomas Gudermann, Johann Schredelseker
Summary: The voltage-dependent anion channel (VDAC) is a main pathway for ions and metabolites across the outer mitochondrial membrane, and its regulation involves various cellular factors and molecular partners. Its specific roles and binding sites, especially the residue E73, are still largely unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Physiology
Varda Shoshan-Barmatz, Uttpal Anand, Edna Nahon-Crystal, Marta Di Carlo, Anna Shteinfer-Kuzmine
Summary: Metformin has been used to treat diabetes and other diseases since the late 1950s. Despite its opposite effects on different diseases, its involvement with VDAC1 suggests that it may be a key factor in metformin's impact on various diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Laura A. Wengert, Sarah J. Backe, Dimitra Bourboulia, Mehdi Mollapour, Mark R. Woodford
Summary: Mitochondrial function relies on molecular chaperones, including heat shock proteins (Hsps) such as Hsp90 and its chaperone TNF-receptor-associated protein-1 (TRAP1). TRAP1, primarily localized in mitochondria, plays a crucial role in cellular metabolic reprogramming and mitochondrial apoptosis. Upregulation of TRAP1 promotes the growth of cancer cells by enhancing glycolytic metabolism and inhibiting mitochondrial permeability transition, while attenuation of TRAP1 induces apoptosis in cancer cells. Furthermore, TRAP1 is subject to post-translational modifications that regulate its function and downstream effectors.
Article
Oncology
Phyllis S. Y. Chong, Jing-Yuan Chooi, Julia S. L. Lim, Aaron C. Y. Leow, Sabrina Hui Min Toh, Irfan Azaman, Mun Yee Koh, Phaik Ju Teoh, Tuan Zea Tan, Tae-Hoon Chung, Wee Joo Chng
Summary: Aberrant glycolysis driven by NSD2-mediated upregulation of PKC alpha can be targeted therapeutically using metabolic inhibitors. Lactate can serve as a biomarker to identify high-risk patients with poor response to IMiD-based regimens.
Editorial Material
Endocrinology & Metabolism
Russel J. Reiter, Ramaswamy Sharma, Qiang Ma
Summary: The circadian melatonin rhythm plays an essential role in reducing the development of diseases such as solid tumors by controlling the metabolism of cancer cells, switching them from aerobic glycolysis to mitochondrial oxidative phosphorylation.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Victor V. Lemeshko
Summary: Recently reported kinase-linked mild depolarization of mitochondria may be a crucial component of the mitochondrial anti-aging program. However, the current measurement methods for mitochondrial inner membrane potential ignore the possibility of outer membrane potential generation. The experimental data reported in this study may reflect changes in the positive outer membrane potential generated by VDAC-kinase complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Review
Biochemistry & Molecular Biology
Aikaterini Poulaki, Stavroula Giannouli
Summary: B lymphocytes play a crucial role in adaptive immunity and memory. Their differentiation and immunological memory are regulated by complex genomic modifications and bioenergetic changes. Despite stringent control mechanisms, B cell malignancies remain prevalent worldwide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Seyedeh Sahar Mortazavi Farsani, Vivek Verma
Summary: New research reveals that not only cancer cells but also other cell types, including immune cells, exhibit the Warburg effect, converting glucose to lactate even in the presence of sufficient oxygen. Lactate plays a crucial role in metabolism and cell signaling, but high levels can inhibit immune cell function.
FRONTIERS IN ONCOLOGY
(2023)
Article
Developmental Biology
Lorena Esteban-Martinez, Miguel Torres
Summary: Cell Competition is a selective process in which viable cells are eliminated through interactions with neighboring cells. Fit cells can eliminate less fit ones, and in some cases, transformed cells can become supercompetitors and eliminate surrounding cells, potentially promoting tumor formation. Energy metabolism plays a central role in various models of cell competition.
DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Annika-Ricarda Kuhn, Marc van Bilsen
Summary: Heart failure is associated with changes in cardiac intermediary metabolism, but the role of metabolic remodeling in heart failure remains unclear. Recent research in cancer has shown that metabolic rewiring directly affects cellular phenotype and function, and similar functions may be served by the rewiring of cardiac cellular metabolism in heart failure. This review discusses the impact of metabolic pathways on cellular phenotype in different cell types of the heart and evaluates their relevance for cardiac pathogenesis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Luca Peruzzotti-Jametti, Cory M. Willis, Regan Hamel, Grzegorz Krzak, Stefano Pluchino
Summary: Patients with chronic neurological conditions, including progressive multiple sclerosis, exhibit pathological changes in neural metabolism and mitochondrial function; It is unclear if a similar degree of metabolic dysfunction occurs in non-neural cells in the central nervous system; Research discusses how cell metabolism and mitochondrial function regulate chronic active microglia and macrophages brain infiltrates, identifying new metabolic targets for therapeutic approaches against smoldering neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Alyssa Torres, Sarah Kang, Christopher B. Mahony, Martha Cedeno, Patricia G. Oliveira, Marta Fernandez-Bustamante, Samuel Kemble, Teresina Laragione, Percio S. Gulko, Adam P. Croft, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma
Summary: The mitochondrial binding of glucose metabolism enzyme HK2 plays a crucial role in regulating the phenotype of rheumatoid arthritis fibroblast-like synoviocytes (FLS). It was found that HK2 protects mitochondria against stress and regulates the aggressive phenotype of RA FLS. New therapeutic approaches focusing on dissociating HK2 from mitochondria offer a safer option for inhibiting the progression of RA FLS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Shaopei Wang, Yan Zhuang, Jindan Xu, Yan Tong, Xiaofei Li, Chunhong Dong
Summary: HK2 has been proven to be a key target for cancer treatment. This study systematically summarised the characteristics of HK2 inhibitors reported in the literature and patents, and analysed and illustrated the structure of small molecules with the catalytic domain of HK2 to develop highly selective and low-toxicity HK2 inhibitors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Russel J. Reiter, Ramaswamy Sharma, Carmen Rodriguez, Vanesa Martin, Sergio Rosales-Corral, Debora Aparecida Pires de Campos Zuccari, Luiz Gustavo de Almeida Chuffa
Summary: This paper explores the relationship between endogenous melatonin and solid tumors, highlighting the potential of using melatonin to influence cancer cell metabolism. It suggests that solid tumors exhibit a healthier metabolic state at night, potentially reducing proliferation and invasiveness. The paper also proposes using melatonin in a time-sensitive treatment paradigm and combining it with traditional chemotherapy for improved outcomes in cancer treatment.
Review
Physiology
Marina Makrecka-Kuka, Edgars Liepinsh, Andrew J. Murray, Helene Lemieux, Maija Dambrova, Kersti Tepp, Marju Puurand, Tuuli Kaambre, Woo H. Han, Paul de Goede, Katie A. O'Brien, Belma Turan, Erkan Tuncay, Yusuf Olgar, Anabela P. Rolo, Carlos M. Palmeira, Neoma T. Boardman, Rob C. I. Wust, Terje S. Larsen
Article
Biochemistry & Molecular Biology
Kersti Tepp, Marju Puurand, Natalja Timohhina, Jekaterina Aid-Vanakova, Indrek Reile, Igor Shevchuk, Vladimir Chekulayev, Margus Eimre, Nadada Peet, Lumme Kadaja, Kalju Paju, Tuuli Kaambre
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Review
Cell Biology
Coert J. Zuurbier, Luc Bertrand, Christoph R. Beauloye, Ioanna Andreadou, Marisol Ruiz-Meana, Nichlas R. Jespersen, Duvaraka Kula-Alwar, Hiran A. Prag, Hans Eric Botker, Maija Dambrova, Christophe Montessuit, Tuuli Kaambre, Edgars Liepinsh, Paul S. Brookes, Thomas Krieg
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Oncology
Egle Rebane-Klemm, Laura Truu, Leenu Reinsalu, Marju Puurand, Igor Shevchuk, Vladimir Chekulayev, Natalja Timohhina, Kersti Tepp, Jelena Bogovskaja, Vladimir Afanasjev, Kuelliki Suurmaa, Vahur Valvere, Tuuli Kaambre
Article
Multidisciplinary Sciences
Ljudmila Klepinina, Aleksandr Klepinin, Laura Truu, Vladimir Chekulayev, Heiki Vija, Kaisa Kuus, Indrek Teino, Martin Pook, Toivo Maimets, Tuuli Kaambre
Summary: The study demonstrates that modulating cell metabolism through NaBT can be an effective strategy for treating colorectal cancer (CRC), with significant impacts on the energy metabolism and differentiation state of CRC cells.
Article
Biochemistry & Molecular Biology
Song Zhang, Satsuki Yamada, Sungjo Park, Aleksandr Klepinin, Tuuli Kaambre, Andre Terzic, Petras Dzeja
Summary: The study revealed that AK2 plays a crucial role in early embryonic development and its loss in adults can lead to sudden heart failure, which is eventually recovered with an adaptive response. The compensatory upregulation of related enzymes and genes highlights the innate plasticity of the AK2-integrated bioenergetics system in maintaining homeostasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Oncology
Leenu Reinsalu, Marju Puurand, Vladimir Chekulayev, Sten Miller, Igor Shevchuk, Kersti Tepp, Egle Rebane-Klemm, Natalja Timohhina, Anton Terasmaa, Tuuli Kaambre
Summary: Metabolic plasticity is the ability of cells to adjust metabolism to environmental changes. Cancer cells exhibit increased metabolic plasticity, allowing them to have a survival advantage and higher proliferative capacity. This enhanced plasticity is characterized by changes in adenine nucleotide transport, impaired regulation of VDAC and reprogrammed energy transfer circuits like AK and CK pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Aleksandr Klepinin, Sten Miller, Indrek Reile, Marju Puurand, Egle Rebane-Klemm, Ljudmila Klepinina, Heiki Vija, Song Zhang, Andre Terzic, Petras Dzeja, Tuuli Kaambre
Summary: The dynamics of ATP phosphoryl turnover and metabolic flux through phosphotransfer pathways in cancer cells are not well understood. In this study, using O-18 phosphometabolite tagging technology, the authors investigated the phosphotransfer dynamics in three breast cancer cell lines and found a decreased turnover of γ- and β-ATP in cancer cells compared to control. They also observed reduced fluxes through HK, CK, and mitochondrial substrate shuttle in aggressive cancer cells. The downregulation of MTCK1A was linked to the decreased CK metabolic flux. However, overexpression of HK2, AK2, and AK6 isoforms in cell compartments could promote aggressive breast cancer growth.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kersti Tepp, Jekaterina Aid-Vanakova, Marju Puurand, Natalja Timohhina, Leenu Reinsalu, Karin Tein, Mario Plaas, Igor Shevchuk, Anton Terasmaa, Tuuli Kaambre
Summary: This study aimed to investigate the role of Wfs1 deficiency on muscle bioenergetics. The results revealed that Wfs1 gene mutation led to a decrease in oxygen consumption rate in muscles, with substrate-dependent alterations. Additionally, it was found that the respiration rate of muscles significantly decreased during the development of WS, although other changes were relatively minor.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Correction
Chemistry, Analytical
Karl Kristjan Kaup, Lauri Toom, Laura Truu, Sten Miller, Marju Puurand, Kersti Tepp, Tuuli Kaambre, Indrek Reile
Article
Chemistry, Analytical
Karl Kristjan Kaup, Lauri Toom, Laura Truu, Sten Miller, Marju Puurand, Kersti Tepp, Tuuli Kaambre, Indrek Reile
Summary: In this study, a combination of established pure shift NMR and artifact suppression techniques was used to record P-31 pure shift NMR spectra without extending measurement times or causing line broadening. This approach successfully resolved overlapping multiplets of homonuclear coupled phosphorus nuclei, demonstrating its potential for phosphometabolomics analysis.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)