Leptin and brain–adipose crosstalks

An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents

(2018) Fang Zhang et al.   Cell Metabolism

Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

(2018) Jingyi Chi et al.   Cell Metabolism

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

(2017) Mafalda M. A. Pereira et al.   Nature Communications

The glucoregulatory actions of leptin

(2017) Anna M. D'souza et al.   Molecular Metabolism

The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

(2017) Cheryl Cero et al.   Molecular Metabolism

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

(2017) Brian Y.H. Lam et al.   Molecular Metabolism

Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats

(2016) Amy Warner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice

(2016) Sébastien M. Labbé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

(2016) Alexandre Caron et al.   Annals of the New York Academy of Sciences

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

(2016) Yi Zhu et al.   Cell Metabolism

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis

(2016) Sangho Yu et al.   JOURNAL OF NEUROSCIENCE

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Leptin Raises Defended Body Temperature without Activating Thermogenesis

(2016) Alexander W. Fischer et al.   Cell Reports

Physiological role for leptin in the control of thermal conductance

(2016) Karl J. Kaiyala et al.   Molecular Metabolism

A stringent validation of mouse adipose tissue identity markers

(2015) Jasper M. A. de Jong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Diet-Induced Obese Mice Retain Endogenous Leptin Action

(2015) Nickki Ottaway et al.   Cell Metabolism

In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis

(2015) Sébastien M. Labbé et al.   FASEB JOURNAL

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

(2015) Fredrick E Henry et al.   eLife

Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression

(2015) Yi-Hsueh Lu et al.   Molecular Metabolism

Short and long sympathetic-sensory feedback loops in white fat

(2014) Vitaly Ryu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central sympathetic innervations to visceral and subcutaneous white adipose tissue

(2014) Ngoc Ly T. Nguyen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The brain and brown fat

(2014) Cristina Contreras et al.   ANNALS OF MEDICINE

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat

(2014) Hai-Bin Ruan et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus

(2014) Garron T. Dodd et al.   Cell Metabolism

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Neural innervation of white adipose tissue and the control of lipolysis

(2014) Timothy J. Bartness et al.   FRONTIERS IN NEUROENDOCRINOLOGY

20 YEARS OF LEPTIN: Leptin at 20: an overview

(2014) Jeffrey Friedman   JOURNAL OF ENDOCRINOLOGY

20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

(2014) Margaret B Allison et al.   JOURNAL OF ENDOCRINOLOGY

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

(2014) Eric D Berglund et al.   NATURE NEUROSCIENCE

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

(2014) Kavon Rezai-Zadeh et al.   Molecular Metabolism

Leptin-sensitive sensory nerves innervate white fat

(2013) Keegan T. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action

(2013) Amanda Laque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

(2013) Tamara Tchkonia et al.   Cell Metabolism

Hypothalamic mTORC1 Signaling Controls Sympathetic Nerve Activity and Arterial Pressure and Mediates Leptin Effects

(2013) Shannon M. Harlan et al.   Cell Metabolism

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Understanding the brown adipocyte as a contributor to energy homeostasis

(2013) Kanta Chechi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Guide to Neurotoxic Animal Models of Parkinson's Disease

(2013) K. Tieu   Cold Spring Harbor Perspectives in Medicine

Glutamate release mediates leptin action on energy expenditure

(2013) Yuanzhong Xu et al.   Molecular Metabolism

GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

(2012) Dong Kong et al.   CELL

Sympathetic activation by chemical stimulation of white adipose tissues in rats

(2012) Zhen Shi et al.   JOURNAL OF APPLIED PHYSIOLOGY

FOSL2 promotes leptin gene expression in human and mouse adipocytes

(2012) Christiane D. Wrann et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid Nitration of Adipocyte Phosphoenolpyruvate Carboxykinase by Leptin Reduces Glyceroneogenesis and Induces Fatty Acid Release

(2012) Anne-Marie Jaubert et al.   PLoS One

New insights into adipocyte-specific leptin gene expression

(2012) Christiane D. Wrann et al.   Adipocyte

Leptin Does Not Directly Affect CNS Serotonin Neurons to Influence Appetite

(2011) Daniel D. Lam et al.   Cell Metabolism

Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons

(2011) Jussara M. do Carmo et al.   HYPERTENSION

Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

(2011) P. J. Enriori et al.   JOURNAL OF NEUROSCIENCE

Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits

(2011) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism

(2011) Karima Begriche et al.   PHYSIOLOGY & BEHAVIOR

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

(2011) K. W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central neural pathways for thermoregulation

(2010) Shaun et al.   Frontiers in Bioscience-Landmark

Transcription factor AP-2β inhibits expression and secretion of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes

(2010) T Fuke et al.   INTERNATIONAL JOURNAL OF OBESITY

Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach

(2010) Laurent Gautron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Distinct Effects of Leptin and a Melanocortin Receptor Agonist Injected Into Medial Hypothalamic Nuclei on Glucose Uptake in Peripheral Tissues

(2009) Chitoku Toda et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation

(2008) Nilton A. Brito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence

(2008) C. Kay Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Anterograde transneuronal viral tract tracing reveals central sensory circuits from white adipose tissue

(2008) C. Kay Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome

(2008) Nathan C. Bingham et al.   ENDOCRINOLOGY

Central control of thermogenesis in mammals

(2008) Shaun F. Morrison et al.   EXPERIMENTAL PHYSIOLOGY

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

(2008) I. Murano et al.   JOURNAL OF ANATOMY

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE